SPAG8 and KLHL32

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		SPAG8	KLHL32
Description		sperm associated antigen 8	kelch like family member 32
Image			No pdb structure
GO Annotations	Cellular Component	Acrosomal Vesicle Male Germ Cell Nucleus Nucleus Nucleoplasm Cytoplasm Microtubule Organizing Center Spindle Cytosol Cytoskeleton Axonemal Microtubule Cilium Membrane Cytoplasmic Vesicle Motile Cilium Sperm Flagellum Cell Projection Axonemal A Tubule Inner Sheath
	Molecular Function	Protein Binding Microtubule Binding	Protein Binding
	Biological Process	Spermatogenesis Single Fertilization Cell Differentiation Flagellated Sperm Motility Positive Regulation Of Transcription By RNA Polymerase II
Pathways
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545)	Blood pressure ( 24954895) Body mass index ( 23583978) Body mass index (adult) ( 28430825) Metabolite levels ( 23823483) Multiple sclerosis (OCB status) ( 23785401) Post bronchodilator FEV1 in COPD ( 26634245) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245) Stroke ( 32693751) Walking pace ( 33128006)
Interacting Genes		87 interacting genes: ACTMAP ARMC5 B9D2 BATF2 CARM1 CCDC120 CCNC CDC23 CFP CSTF2 CSTF2T CTAG1A CTAG1B DMRT3 DOK3 DTX2 DYNLL2 EGFL7 FAM168B GIGYF1 GLYCTK GPSM3 HR INCA1 INTS11 JMJD4 KDM3B KLHL32 KRT34 KRTAP10-8 KRTAP11-1 KRTAP13-3 KRTAP15-1 KRTAP19-2 KRTAP19-6 KRTAP19-7 KRTAP21-2 KRTAP26-1 KRTAP3-1 KRTAP6-2 KRTAP7-1 LASP1 MEOX1 METTL15 MGAT5B NEDD4L NHLRC4 NSD3 NUDT21 PATZ1 PEF1 PFDN5 PHF1 PITX1 PLA2G10 PRMT1 PRMT2 PRMT5 PRR35 RAN RBP3 RIPK4 RNF125 RUSC1 SERGEF SMUG1 SMYD1 SNRPB SNRPC SYNGAP1 TEKT3 TEKT5 TENT5B TRIB3 TRIM42 TSC1 TTC23 UBAP2 UBQLN1 UBQLN4 USP2 VPS37C YPEL3 ZBTB32 ZIC1 ZNF34 ZNF581	9 interacting genes: APP C1orf94 CRX MEOX2 NUP62 PARVG REL SPAG8 TCF4
Entrez ID		26206	114792
HPRD ID		12039	13898
Ensembl ID		ENSG00000137098	ENSG00000186231
Uniprot IDs		A0A140VJV0 Q99932	A0A087WYQ8 Q6IQ08 Q96NJ5
PDB IDs		7UNG 8J07
Enriched GO Terms of Interacting Partners?		Intermediate Filament Protein-arginine N-methyltransferase Activity Protein Binding Histone Methyltransferase Activity Protein-arginine Omega-N Asymmetric Methyltransferase Activity Methylation Methyltransferase Activity Methylosome Protein Methylation Histone Arginine N-methyltransferase Activity MRNA Cleavage And Polyadenylation Specificity Factor Complex Keratin Filament Histone H3K9me/H3K9me2 Demethylase Activity Histone H3 Methyltransferase Activity Histone H4R3 Methyltransferase Activity Peptidyl-arginine Methylation Macromolecule Methylation	PTB Domain Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process DNA-binding Transcription Factor Activity Positive Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Response To Calcium Ion Amylin Binding Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Toll Signaling Pathway Acetylcholine Receptor Activator Activity Positive Regulation Of Neuron Differentiation Lipoprotein Particle Positive Regulation Of Protein Import RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Chromatin Binding Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Chromatin Beta-catenin-TCF7L2 Complex Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling NF-kappaB Complex TFIIB-class Transcription Factor Binding Establishment Or Maintenance Of Cell Polarity Regulating Cell Shape DNA Binding Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition
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