SPAG8 and CARM1

Number of citations of the paper that reports this interaction (PMID 23455924)
3

Data Source:
BioGRID (two hybrid)

		SPAG8	CARM1
Gene Name		sperm associated antigen 8	coactivator-associated arginine methyltransferase 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Acrosomal Vesicle Nucleus Membrane	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Molecular_function Microtubule Binding	Transcription Coactivator Activity Protein Binding Beta-catenin Binding Protein Methyltransferase Activity Histone-arginine N-methyltransferase Activity Protein-arginine N-methyltransferase Activity Ligand-dependent Nuclear Receptor Transcription Coactivator Activity Protein-arginine Omega-N Asymmetric Methyltransferase Activity Histone Methyltransferase Activity (H3-R17 Specific) Histone Methyltransferase Activity Protein Homodimerization Activity Transcription Regulatory Region DNA Binding Lysine-acetylated Histone Binding
	Biological Process	Biological_process Positive Regulation Of Protein Binding Positive Regulation Of Transcription From RNA Polymerase II Promoter	Regulation Of Growth Plate Cartilage Chondrocyte Proliferation Chromatin Organization Transcription, DNA-templated Regulation Of Transcription, DNA-templated Positive Regulation Of Cell Proliferation Pathogenesis Viral Process Histone Methylation Peptidyl-arginine Methylation, To Asymmetrical-dimethyl Arginine Intracellular Estrogen Receptor Signaling Pathway Negative Regulation Of Protein Binding Regulation Of Intracellular Estrogen Receptor Signaling Pathway Histone H3-R2 Methylation Histone H3-R17 Methylation Cellular Lipid Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Fat Cell Differentiation Response To CAMP Endochondral Bone Morphogenesis
Pathways			PPARA activates gene expression Organelle biogenesis and maintenance Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Chromatin organization REV-ERBA represses gene expression RORA activates circadian gene expression Mitochondrial biogenesis RMTs methylate histone arginines Regulation of cholesterol biosynthesis by SREBP (SREBF) Chromatin modifying enzymes Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation YAP1- and WWTR1 (TAZ)-stimulated gene expression Activation of gene expression by SREBF (SREBP) Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Transcriptional activation of mitochondrial biogenesis BMAL1:CLOCK,NPAS2 activates circadian gene expression Orphan transporters
Drugs
Diseases
GWAS
Protein-Protein Interactions		15 interactors: CARM1 CSTF2 DTX2 JMJD4 KDM3B KLHL32 NEDD4L PITX1 PRMT1 PRMT2 PRMT5 RAN SNRPC UBQLN4 WHSC1L1	33 interactors: AXIN1 CREBBP CTNNB1 DAXX DNAJA3 ELAVL1 EP300 FLII FOS GRIP1 H3F3A H3F3B HIST1H3A MALT1 MEF2D MYOD1 MYOG NCOA1 NCOA2 NUDT21 PABPC1 PABPN1 PIAS1 PYGO1 QKI RABGAP1 RELA SMARCA4 SPAG8 SRC SRCAP TP53 UBE2I
Entrez ID		26206	10498
HPRD ID		12039	09158
Ensembl ID		ENSG00000137098	ENSG00000142453
Uniprot IDs		Q99932	Q86X55
PDB IDs			2Y1W 2Y1X 4IKP
Enriched GO Terms of Interacting Partners?		Peptidyl-arginine N-methylation Histone Arginine Methylation Peptidyl-arginine Methylation Histone Methylation Peptidyl-arginine Methylation, To Asymmetrical-dimethyl Arginine Protein Methylation Chromatin Modification Chromatin Organization Histone Modification Methylation Chromosome Organization Gene Expression Histone H4-R3 Methylation Regulation Of Transcription, DNA-templated RNA Metabolic Process Regulation Of Nucleic Acid-templated Transcription Transcription, DNA-templated Regulation Of RNA Biosynthetic Process Peptidyl-amino Acid Modification Regulation Of RNA Metabolic Process RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Spliceosomal SnRNP Assembly Regulation Of Nitrogen Compound Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Cellular Nitrogen Compound Metabolic Process Cellular Metabolic Process Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Nitrogen Compound Metabolic Process Organelle Organization Histone H3-R17 Methylation Cellular Protein Modification Process Ribonucleoprotein Complex Biogenesis Intracellular Steroid Hormone Receptor Signaling Pathway RNA Splicing Regulation Of Metabolic Process Histone H3-R2 Methylation Peptidyl-arginine Methylation, To Symmetrical-dimethyl Arginine Positive Regulation Of Caveolin-mediated Endocytosis Cellular Macromolecule Biosynthetic Process MRNA Processing Macromolecule Biosynthetic Process Ribosomal Small Subunit Export From Nucleus Branchiomeric Skeletal Muscle Development MRNA 5'-splice Site Recognition Regulation Of Growth Plate Cartilage Chondrocyte Proliferation	Regulation Of Gene Expression Regulation Of RNA Metabolic Process Positive Regulation Of Gene Expression Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Nitrogen Compound Metabolic Process Peptidyl-lysine Modification Chromatin Organization Transcription, DNA-templated Histone Acetylation RNA Biosynthetic Process Nitrogen Compound Metabolic Process Internal Peptidyl-lysine Acetylation Intracellular Receptor Signaling Pathway Peptidyl-lysine Acetylation Negative Regulation Of Cellular Metabolic Process Internal Protein Amino Acid Acetylation RNA Metabolic Process Protein Acetylation Intracellular Steroid Hormone Receptor Signaling Pathway Organelle Organization Androgen Receptor Signaling Pathway Cellular Macromolecule Biosynthetic Process DNA Methylation On Cytosine Negative Regulation Of Transcription From RNA Polymerase II Promoter Macromolecule Biosynthetic Process Regulation Of Cellular Process Chromosome Organization Transcription From RNA Polymerase II Promoter Muscle Structure Development DNA Methylation
Tagcloud ?		azoospermia bonferroni cgtg chinese conferred correction crem haplotype idiopathic iplex kif17b maturation noa nonobstructive played polymorphisms protective rs1148247 rs11592356 rs2295415 rs22954152 rs4934540 sequenom seventeen snps spermatogenesis tag tatg variants	additionally arginine biological blocked candidates cardiovascular cofactor compound cyanine docking effectively guide methyltransferase micromolar occupying optimization pentamethine permeated prmt1 prmt5 prmt8 probes provided roadmap selectivity serve systematically transduction trimethine
Tagcloud (Difference) ?		azoospermia bonferroni cgtg chinese conferred correction crem haplotype idiopathic iplex kif17b maturation noa nonobstructive played polymorphisms protective rs1148247 rs11592356 rs2295415 rs22954152 rs4934540 sequenom seventeen snps spermatogenesis tag tatg variants	additionally arginine biological blocked candidates cardiovascular cofactor compound cyanine docking effectively guide methyltransferase micromolar occupying optimization pentamethine permeated prmt1 prmt5 prmt8 probes provided roadmap selectivity serve systematically transduction trimethine
Tagcloud (Intersection) ?