SPAG8 and RAN

Number of citations of the paper that reports this interaction (PubMedID 15014887)
0

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		SPAG8	RAN
Description		sperm associated antigen 8	RAN, member RAS oncogene family
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GO Annotations	Cellular Component	Acrosomal Vesicle Male Germ Cell Nucleus Nucleus Nucleoplasm Cytoplasm Microtubule Organizing Center Spindle Cytosol Cytoskeleton Axonemal Microtubule Cilium Membrane Cytoplasmic Vesicle Motile Cilium Sperm Flagellum Cell Projection Axonemal A Tubule Inner Sheath	Chromatin Male Germ Cell Nucleus Manchette Nucleus Nuclear Envelope Nuclear Pore Nucleoplasm Nucleolus Cytoplasm Centriole Cytosol Membrane Midbody Protein-containing Complex Sperm Flagellum Melanosome RNA Nuclear Export Complex Recycling Endosome Extracellular Exosome Flemming Body
	Molecular Function	Protein Binding Microtubule Binding	Nucleotide Binding Magnesium Ion Binding Chromatin Binding RNA Binding GTPase Activity G Protein Activity Nuclear Export Signal Receptor Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding Protein Domain Specific Binding Protein-containing Complex Binding Cadherin Binding Dynein Intermediate Chain Binding Metal Ion Binding Protein Heterodimerization Activity Importin-alpha Family Protein Binding Pre-miRNA Binding
	Biological Process	Spermatogenesis Single Fertilization Cell Differentiation Flagellated Sperm Motility Positive Regulation Of Transcription By RNA Polymerase II	Ribosomal Subunit Export From Nucleus Ribosomal Large Subunit Export From Nucleus Ribosomal Small Subunit Export From Nucleus Mitotic Sister Chromatid Segregation Mitotic Cell Cycle Glycolytic Process DNA Metabolic Process Protein Import Into Nucleus Protein Export From Nucleus Nucleocytoplasmic Transport Mitotic Spindle Organization Spermatid Development Intracellular Protein Localization Protein Transport Viral Process Hippocampus Development Actin Cytoskeleton Organization Protein-containing Complex Localization Pre-miRNA Export From Nucleus Positive Regulation Of Protein Import Into Nucleus GTP Metabolic Process Cell Division SnRNA Import Into Nucleus Cellular Response To Mineralocorticoid Stimulus Protein Localization To Nucleolus
Pathways			Rev-mediated nuclear export of HIV RNA Regulation of cholesterol biosynthesis by SREBP (SREBF) NEP/NS2 Interacts with the Cellular Export Machinery Nuclear import of Rev protein MicroRNA (miRNA) biogenesis Transcriptional regulation by small RNAs tRNA processing in the nucleus Postmitotic nuclear pore complex (NPC) reformation Postmitotic nuclear pore complex (NPC) reformation
Drugs			Guanosine-5'-Diphosphate
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545)
Interacting Genes		87 interacting genes: ACTMAP ARMC5 B9D2 BATF2 CARM1 CCDC120 CCNC CDC23 CFP CSTF2 CSTF2T CTAG1A CTAG1B DMRT3 DOK3 DTX2 DYNLL2 EGFL7 FAM168B GIGYF1 GLYCTK GPSM3 HR INCA1 INTS11 JMJD4 KDM3B KLHL32 KRT34 KRTAP10-8 KRTAP11-1 KRTAP13-3 KRTAP15-1 KRTAP19-2 KRTAP19-6 KRTAP19-7 KRTAP21-2 KRTAP26-1 KRTAP3-1 KRTAP6-2 KRTAP7-1 LASP1 MEOX1 METTL15 MGAT5B NEDD4L NHLRC4 NSD3 NUDT21 PATZ1 PEF1 PFDN5 PHF1 PITX1 PLA2G10 PRMT1 PRMT2 PRMT5 PRR35 RAN RBP3 RIPK4 RNF125 RUSC1 SERGEF SMUG1 SMYD1 SNRPB SNRPC SYNGAP1 TEKT3 TEKT5 TENT5B TRIB3 TRIM42 TSC1 TTC23 UBAP2 UBQLN1 UBQLN4 USP2 VPS37C YPEL3 ZBTB32 ZIC1 ZNF34 ZNF581	62 interacting genes: ABL1 ADRB2 AR ASAP2 BCAR1 BIRC5 BMPR1B CEP126 CSE1L DUX4 EP300 FNDC3B FOXP1 GADD45G GIT1 IPO11 IPO13 IPO4 IPO5 IPO7 IPO8 IPO9 KPNB1 MBP MSL1 NEK9 NR3C1 NSMF NUP153 NUP50 NUTF2 NXF1 NXT1 PAK4 PARP10 PTMA RANBP1 RANBP10 RANBP2 RANBP3 RANBP9 RANGAP1 RANGRF RCC1 RGPD5 RPL7 SMAD1 SMAD2 SMARCB1 SMURF2 SPAG8 SSRP1 SUMO2 TGFBR1 TNPO1 VRK2 VRK3 XPO1 XPO4 XPO5 XPO7 XPOT
Entrez ID		26206	5901
HPRD ID		12039	03109
Ensembl ID		ENSG00000137098	ENSG00000132341
Uniprot IDs		A0A140VJV0 Q99932	B4DV51 P62826
PDB IDs		7UNG 8J07	1I2M 1IBR 1K5D 1K5G 1QBK 1RRP 2MMC 2MMG 2N1B 3CH5 3EA5 3GJ0 3GJ3 3GJ4 3GJ5 3GJ6 3GJ7 3GJ8 3GJX 3NBY 3NBZ 3NC0 3NC1 3ZJY 4C0Q 4GMX 4GPT 4HAT 4HAU 4HAV 4HAW 4HAX 4HAY 4HAZ 4HB0 4HB2 4HB3 4HB4 4OL0 4WVF 5CIQ 5CIT 5CIW 5CJ2 5CLL 5CLQ 5DH9 5DHA 5DHF 5DI9 5DIF 5DIS 5DLQ 5FYQ 5JLJ 5UWH 5UWI 5UWJ 5UWO 5UWP 5UWQ 5UWR 5UWS 5UWT 5UWU 5UWW 5YRO 5YST 5YSU 5YTB 5ZPU 6A38 6A3A 6A3B 6A3C 6A3E 6CIT 6KFT 6LQ9 6M60 6M6X 6Q82 6Q84 6TVO 6X2M 6X2O 6X2P 6X2R 6X2S 6X2U 6X2V 6X2W 6X2X 6X2Y 6XJP 6XJR 6XJS 6XJT 6XJU 7B51 7CND 7DBG 7L5E 7MNP 7MNQ 7MNR 7MNS 7MNT 7MNU 7MNV 7MNW 7MNX 7MNY 7MNZ 7MO0 7MO1 7MO2 7MO3 7MO4 7MO5 7YPZ 8HQ3 8HQ4 8HQ5 8HQ6 8HUF 8HUG 8ITV 8UX1 9B62
Enriched GO Terms of Interacting Partners?		Intermediate Filament Protein-arginine N-methyltransferase Activity Protein Binding Histone Methyltransferase Activity Protein-arginine Omega-N Asymmetric Methyltransferase Activity Methylation Methyltransferase Activity Methylosome Protein Methylation Histone Arginine N-methyltransferase Activity MRNA Cleavage And Polyadenylation Specificity Factor Complex Keratin Filament Histone H3K9me/H3K9me2 Demethylase Activity Histone H3 Methyltransferase Activity Histone H4R3 Methyltransferase Activity Peptidyl-arginine Methylation Macromolecule Methylation	Small GTPase Binding Nuclear Transport Nucleocytoplasmic Transport Nuclear Pore Protein Import Into Nucleus Import Into Nucleus Intracellular Protein Transport Protein Localization To Nucleus Nucleus Nuclear Export Nuclear Envelope Establishment Of Localization In Cell Intracellular Transport Protein Transport Nucleoplasm Cellular Localization Protein Export From Nucleus Nuclear Import Signal Receptor Activity Protein Localization To Organelle Establishment Of Protein Localization To Organelle Establishment Of Protein Localization Intracellular Protein Localization RNA Transport Cytoplasm Nuclear Export Signal Receptor Activity Nuclear Membrane Nucleobase-containing Compound Transport Nuclear Localization Sequence Binding Cytosol Ribosomal Protein Import Into Nucleus Regulation Of Nucleocytoplasmic Transport MRNA Transport RNA Export From Nucleus Protein-containing Complex SMAD Binding NLS-bearing Protein Import Into Nucleus Protein Binding Nuclear Inclusion Body Homomeric SMAD Protein Complex Cytoplasmic Periphery Of The Nuclear Pore Complex Response To Growth Factor Mitotic Spindle Organization I-SMAD Binding Regulation Of Intracellular Transport Cellular Response To Growth Factor Stimulus Negative Regulation Of RNA Export From Nucleus SUMO Ligase Complex Nuclear Pore Cytoplasmic Filaments Microtubule Cytoskeleton Organization Involved In Mitosis Regulation Of Cell Cycle
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