TRAF3IP1 and ITSN1

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		TRAF3IP1	ITSN1
Description		TRAF3 interacting protein 1	intersectin 1
Image
GO Annotations	Cellular Component	Fibrillar Center Nucleoplasm Cytoplasm Centrosome Cytoskeleton Cilium Axoneme Nuclear Body Intraciliary Transport Particle B Ciliary Transition Zone Ciliary Basal Body Cell Projection Ciliary Tip Ciliary Base	Nucleus Nuclear Envelope Cytoplasm Endosome Cytosol Plasma Membrane Clathrin-coated Pit Endomembrane System Membrane Lamellipodium Cytoplasmic Vesicle Presynaptic Membrane Cell Projection Neuron Projection Neuronal Cell Body Dendritic Spine Synapse Recycling Endosome Apical Dendrite Intracellular Vesicle Postsynaptic Endocytic Zone Postsynaptic Actin Cytoskeleton Glutamatergic Synapse
	Molecular Function	Protein Binding Microtubule Binding	Guanyl-nucleotide Exchange Factor Activity Calcium Ion Binding Protein Binding Protein-macromolecule Adaptor Activity Metal Ion Binding Molecular Adaptor Activity Proline-rich Region Binding
	Biological Process	Morphogenesis Of A Polarized Epithelium Kidney Development Negative Regulation Of Protein Phosphorylation Neural Tube Patterning Cell Projection Organization Embryonic Camera-type Eye Development Negative Regulation Of Protein-containing Complex Assembly Negative Regulation Of Type I Interferon Production Negative Regulation Of Interferon-beta Production Embryonic Heart Tube Development Intraciliary Anterograde Transport Post-anal Tail Morphogenesis Intraciliary Transport Embryonic Digit Morphogenesis Negative Regulation Of Smoothened Signaling Pathway Animal Organ Development System Development Negative Regulation Of Defense Response To Virus Defense Response To Virus Cilium Assembly Regulation Of Microtubule Cytoskeleton Organization	Exocytosis Endocytosis Intracellular Protein Localization Regulation Of Cell Communication Protein Transport Endosomal Transport Regulation Of Signaling Intracellular Signal Transduction Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Growth Hormone Secretion Positive Regulation Of Dendritic Spine Development Regulation Of Postsynapse Organization Clathrin-dependent Synaptic Vesicle Endocytosis Regulation Of Modification Of Postsynaptic Actin Cytoskeleton Positive Regulation Of Caveolin-mediated Endocytosis
Pathways		Intraflagellar transport Intraflagellar transport	NRAGE signals death through JNK EPHB-mediated forward signaling EPHB-mediated forward signaling G alpha (12/13) signalling events Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis CDC42 GTPase cycle RHOQ GTPase cycle RHOG GTPase cycle
Drugs
Diseases
GWAS		Chronotype ( 30696823) FEV1 ( 30804560) Intraocular pressure ( 29617998 29785010 30054594) Iris characteristics ( 21835309) Lung function (FEV1/FVC) ( 28166213 30804560) Metabolite levels ( 23823483) Morning person ( 30696823) Refractive astigmatism ( 30306274) Refractive error ( 32231278) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)	Bitter non-alcoholic beverage consumption ( 31046077) Educational attainment ( 25201988) Height ( 31562340) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) QT interval ( 29213071) Red blood cell count ( 32888494) Red cell distribution width ( 27863252 32888494) Tonsillectomy ( 27182965 28928442)
Interacting Genes		31 interacting genes: ABI2 APP CCDC93 CCNA2 CDC5L DISC1 DMD DST DTNBP1 EXOC1 FRMD4A GOLGA4 IL13RA1 IMMT ITSN1 MACF1 OLFM1 PCNT SFR1 SGF29 SMC2 SMC3 SMC4 SNAP91 SPTBN1 TAB2 TRAF3 TRAF6 TRAK1 UBXN10 WAC	140 interacting genes: AGFG1 AGFG2 AJUBA ANKRD36 ANKRD54 ARF6 ARFIP2 ARHGAP31 ASAP2 BECN1 BFSP1 BRCC3 BRWD3 CCDC24 CCNO CDC42 CEP85L CLIP2 CLTC COG4 CSNK2B CYTH1 CYTH3 DAB1 DAB2 DES DISC1 DLGAP1 DNAI7 DNAJA2 DNM1 DNM2 DST DYNC1H1 EEF1A1 EPHB2 EPN2 EPS15 EXOC1 FCHO1 FCHO2 FCHSD2 FNBP1 FNBP4 GAREM2 GCC1 GFAP GNPTG GOLGA5 HIP1 HNRNPK HRAS IFT74 ITSN2 KHDRBS1 KIF16B KIF5A KIF5C KRT222 LMO3 LMO4 MAP3K20 MAPK6 MAPK8IP2 MED4 MRPL20 MTUS2 MYH14 NASP NEFL NEFM NEMF PACSIN3 PDCD6IP PDE2A PDZD8 PFDN5 PICALM PIK3AP1 PIK3C2B PIK3R1 PLK1 PPFIA2 PPL PREX1 PRRG4 RAB11FIP2 RAB5A RABEP1 RAI14 RALBP1 REPS1 REPS2 RIN1 RNF40 RPS6KA5 RRBP1 SCAI SCAMP1 SCOC SF3B4 SH3GL2 SHANK3 SIAH1 SMARCC2 SMC1A SNAP23 SNAP25 SNRNP70 SNX5 SNX6 SOS1 SOS2 SPDL1 SPECC1 SPRY2 SPTAN1 SPTBN1 STON2 SYNC SYNE1 SYNJ1 SYNJ2 TK1 TRAF3IP1 TRIM5 TRIM8 TRPM7 TSG101 TTC27 UBC UBE2K UNC119 VLDLR WASL WBP11 WHAMM ZFC3H1 ZFPM2 ZMYM5
Entrez ID		26146	6453
HPRD ID		09571	03898
Ensembl ID		ENSG00000204104	ENSG00000205726
Uniprot IDs		Q8TDR0	A7XZY7 F8W7U0 Q15811 Q6PD56
PDB IDs		2EQO 8KCQ	1KI1 2KGR 2KHN 3FIA 3QBV 4IIM 5HZI 5HZJ 5HZK 6GBU 6H5T
Enriched GO Terms of Interacting Partners?		Golgi To Plasma Membrane Transport Post-Golgi Vesicle-mediated Transport Positive Regulation Of Cellular Component Organization Vesicle-mediated Transport To The Plasma Membrane Regulation Of Postsynapse Organization Organelle Organization Regulation Of Neuron Projection Development Positive Regulation Of Axonogenesis Axo-dendritic Transport Regulation Of Axon Extension Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Regulation Of Cellular Component Organization Positive Regulation Of Cell Projection Organization Golgi To Plasma Membrane Protein Transport Cytoskeleton Organization Positive Regulation Of Axon Extension Meiotic Chromosome Condensation Establishment Of Protein Localization Condensin Complex Positive Regulation Of Chromosome Condensation Cilium Assembly Positive Regulation Of Cell Differentiation Regulation Of Axonogenesis Golgi Vesicle Transport Regulation Of Dendritic Spine Development Dendritic Spine Establishment Of Protein Localization To Plasma Membrane Vesicle-mediated Transport Cilium Organization CD40 Receptor Complex TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Synapse Organization Axon Cytoplasm Axonal Transport Cellular Localization Organelle Assembly Regulation Of Developmental Growth Transport Along Microtubule Clathrin-coated Pit MyD88-independent Toll-like Receptor Signaling Pathway Meiotic Chromosome Segregation Regulation Of Chromosome Condensation Endosome Molecular Adaptor Activity Cytoskeleton-dependent Intracellular Transport Positive Regulation Of Developmental Process Plasma Membrane Bounded Cell Projection Assembly Signaling Adaptor Activity Mitotic Chromosome Condensation	Endocytosis Vesicle-mediated Transport Import Into Cell Cytoplasm Cytosol Establishment Of Localization In Cell Clathrin-coated Pit Clathrin Coat Assembly Cytoskeleton Organization Organelle Organization Cytoskeleton Regulation Of Cellular Component Organization Receptor-mediated Endocytosis Organelle Localization Membrane Organization Cellular Component Assembly Clathrin-coated Vesicle Protein Transport Clathrin-dependent Endocytosis Intermediate Filament-based Process Cellular Localization Establishment Of Organelle Localization Intracellular Transport Negative Regulation Of Cellular Component Organization Synaptic Vesicle Endocytosis Establishment Of Protein Localization Regulation Of Protein Localization To Cell Periphery Presynaptic Endocytosis Vesicle-mediated Transport In Synapse Intermediate Filament Cytoskeleton Organization Intracellular Protein Localization Protein-containing Complex Assembly Clathrin Coat Of Coated Pit Intermediate Filament Cytoskeleton Protein-containing Complex Organization Structural Constituent Of Cytoskeleton Post-Golgi Vesicle-mediated Transport Glutamatergic Synapse Microtubule Binding Establishment Of Vesicle Localization Endosomal Transport Cell Cortex Cytoplasmic Vesicle Golgi Vesicle Transport Regulation Of Protein Localization To Plasma Membrane Vesicle Localization Cytoskeleton-dependent Intracellular Transport Cell Projection Organization Mitotic Cytokinesis Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
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