TRAF3IP1 and SMC4

Number of citations of the paper that reports this interaction (PubMedID 17043677)
0

Data Source:
BioGRID (two hybrid)

		TRAF3IP1	SMC4
Description		TRAF3 interacting protein 1	structural maintenance of chromosomes 4
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GO Annotations	Cellular Component	Fibrillar Center Nucleoplasm Cytoplasm Centrosome Cytoskeleton Cilium Axoneme Nuclear Body Intraciliary Transport Particle B Ciliary Transition Zone Ciliary Basal Body Cell Projection Ciliary Tip Ciliary Base	Chromosome, Centromeric Region Condensed Nuclear Chromosome Condensin Complex Nucleus Nucleoplasm Chromosome Cytoplasm Cytosol Nuclear Speck Nuclear Lumen
	Molecular Function	Protein Binding Microtubule Binding	Nucleotide Binding Chromatin Binding Single-stranded DNA Binding Protein Binding ATP Binding ATP Hydrolysis Activity
	Biological Process	Morphogenesis Of A Polarized Epithelium Kidney Development Negative Regulation Of Protein Phosphorylation Neural Tube Patterning Cell Projection Organization Embryonic Camera-type Eye Development Negative Regulation Of Protein-containing Complex Assembly Negative Regulation Of Type I Interferon Production Negative Regulation Of Interferon-beta Production Embryonic Heart Tube Development Intraciliary Anterograde Transport Post-anal Tail Morphogenesis Intraciliary Transport Embryonic Digit Morphogenesis Negative Regulation Of Smoothened Signaling Pathway Animal Organ Development System Development Negative Regulation Of Defense Response To Virus Defense Response To Virus Cilium Assembly Regulation Of Microtubule Cytoskeleton Organization	Mitotic Sister Chromatid Segregation Nuclear Division Mitotic Chromosome Condensation Meiotic Chromosome Condensation Chromosome Condensation Meiotic Chromosome Segregation Chromosome Organization Cell Division Kinetochore Organization Positive Regulation Of Chromosome Segregation Nuclear Chromosome Segregation Positive Regulation Of Chromosome Separation Positive Regulation Of Chromosome Condensation
Pathways		Intraflagellar transport Intraflagellar transport	Condensation of Prophase Chromosomes Condensation of Prometaphase Chromosomes Condensation of Prometaphase Chromosomes
Drugs
Diseases
GWAS		Chronotype ( 30696823) FEV1 ( 30804560) Intraocular pressure ( 29617998 29785010 30054594) Iris characteristics ( 21835309) Lung function (FEV1/FVC) ( 28166213 30804560) Metabolite levels ( 23823483) Morning person ( 30696823) Refractive astigmatism ( 30306274) Refractive error ( 32231278) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)	Alcohol use disorder (total score) ( 30336701) Bipolar disorder ( 31043756) Malaria ( 31844061)
Interacting Genes		31 interacting genes: ABI2 APP CCDC93 CCNA2 CDC5L DISC1 DMD DST DTNBP1 EXOC1 FRMD4A GOLGA4 IL13RA1 IMMT ITSN1 MACF1 OLFM1 PCNT SFR1 SGF29 SMC2 SMC3 SMC4 SNAP91 SPTBN1 TAB2 TRAF3 TRAF6 TRAK1 UBXN10 WAC	6 interacting genes: CEBPA NCAPD2 PTEN SMC2 SUMO2 TRAF3IP1
Entrez ID		26146	10051
HPRD ID		09571	09276
Ensembl ID		ENSG00000204104	ENSG00000113810
Uniprot IDs		Q8TDR0	B3KXX5 E9PD53 Q58F29 Q9NTJ3
PDB IDs		2EQO 8KCQ	4U4P
Enriched GO Terms of Interacting Partners?		Golgi To Plasma Membrane Transport Post-Golgi Vesicle-mediated Transport Positive Regulation Of Cellular Component Organization Vesicle-mediated Transport To The Plasma Membrane Regulation Of Postsynapse Organization Organelle Organization Regulation Of Neuron Projection Development Positive Regulation Of Axonogenesis Axo-dendritic Transport Regulation Of Axon Extension Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Regulation Of Cellular Component Organization Positive Regulation Of Cell Projection Organization Golgi To Plasma Membrane Protein Transport Cytoskeleton Organization Positive Regulation Of Axon Extension Meiotic Chromosome Condensation Establishment Of Protein Localization Condensin Complex Positive Regulation Of Chromosome Condensation Cilium Assembly Positive Regulation Of Cell Differentiation Regulation Of Axonogenesis Golgi Vesicle Transport Regulation Of Dendritic Spine Development Dendritic Spine Establishment Of Protein Localization To Plasma Membrane Vesicle-mediated Transport Cilium Organization CD40 Receptor Complex TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Synapse Organization Axon Cytoplasm Axonal Transport Cellular Localization Organelle Assembly Regulation Of Developmental Growth Transport Along Microtubule Clathrin-coated Pit MyD88-independent Toll-like Receptor Signaling Pathway Meiotic Chromosome Segregation Regulation Of Chromosome Condensation Endosome Molecular Adaptor Activity Cytoskeleton-dependent Intracellular Transport Positive Regulation Of Developmental Process Plasma Membrane Bounded Cell Projection Assembly Signaling Adaptor Activity Mitotic Chromosome Condensation	Condensin Complex Meiotic Chromosome Condensation Positive Regulation Of Chromosome Condensation Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Chromosome Condensation Mitotic Chromosome Condensation Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Positive Regulation Of Chromosome Segregation Nuclear Chromosome Positive Regulation Of Chromosome Separation Condensed Chromosome Chromosome Condensation Condensed Nuclear Chromosome Nucleoplasm Chromosome Organization Involved In Meiotic Cell Cycle Regulation Of Cell Cycle Regulation Of Proteolysis Regulation Of Chromosome Separation Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Negative Regulation Of Synaptic Vesicle Clustering Organelle Organization Positive Regulation Of Catabolic Process Response To Vitamin B2 C/EBP Complex Positive Regulation Of Proteasomal Protein Catabolic Process Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity PML Body Negative Regulation Of Phosphorylation Negative Regulation Of Protein Phosphorylation Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Positive Regulation Of Chromosome Organization Regulation Of Protein Metabolic Process Regulation Of Chromosome Segregation Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process CHOP-C/EBP Complex Central Nervous System Myelin Maintenance Rhythmic Synaptic Transmission Regulation Of Osteoblast Differentiation Embryonic Organ Development White Fat Cell Proliferation Negative Regulation Of Wound Healing, Spreading Of Epidermal Cells Negative Regulation Of Phosphate Metabolic Process Regulation Of Cell Cycle Process Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex
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