SERBP1 and TOPORS

Number of citations of the paper that reports this interaction (PubMedID 16679534)
0

Data Source:
HPRD (in vivo, two hybrid)

		SERBP1	TOPORS
Description		SERPINE1 mRNA binding protein 1	TOP1 binding arginine/serine rich protein, E3 ubiquitin ligase
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Membrane Perinuclear Region Of Cytoplasm Extracellular Exosome	Ubiquitin Ligase Complex Spindle Pole Gamma-tubulin Complex Nucleus Nucleoplasm Centriole PML Body Nuclear Speck Midbody Photoreceptor Connecting Cilium Ciliary Basal Body
	Molecular Function	RNA Binding MRNA 3'-UTR Binding Protein Binding Translation Repressor Activity SUMO Binding Ribosome Binding Cadherin Binding Translation Elongation Factor Binding	DNA Binding Antigen Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity SUMO Transferase Activity DNA Topoisomerase Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Regulation Of Translation Negative Regulation Of Translation PML Body Organization Regulation Of MRNA Stability Ribosome Hibernation	Protein Polyubiquitination DNA-templated Transcription Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination DNA Damage Response Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Retina Layer Formation Protein Sumoylation Protein Localization To Nucleus Photoreceptor Cell Outer Segment Organization Regulation Of Cell Population Proliferation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of DNA-templated Transcription Maintenance Of Protein Location In Nucleus Protein K48-linked Ubiquitination
Pathways			SUMOylation of transcription cofactors SUMOylation of SUMOylation proteins SUMOylation of immune response proteins
Drugs
Diseases			Retinitis pigmentosa (RP)
GWAS		Bone mineral density (hip) ( 30172743) Carotid plaque burden ( 28282560) Crohn's disease ( 22412388 28067908) DHEAS levels ( 34748635) Inflammatory bowel disease ( 28067908) Primary biliary cholangitis ( 26394269) Ulcerative colitis ( 28067908)	Early spontaneous preterm birth ( 31194736) Immune response to smallpox vaccine (IL-6) ( 22610502) Metabolite levels ( 23823483)
Interacting Genes		27 interacting genes: - APP CHD3 CSNK2A1 DANCR DAXX ESR1 FBXO25 FXYD3 H19 KAT2B LINC00624 OGT PIAS1 PIAS3 PIAS4 PICK1 PRMT8 TDG TERT TOPORS UBA2 UPF2 USP7 VAV2 VIM WEE2-AS1	30 interacting genes: CASP8 CREBBP EPM2A HABP4 MTDH NKX3-1 PRMT1 RAD51 SATB1 SERBP1 SETX SIN3A SNIP1 SPOP SUMO1 SUMO2 TOP1 TP53 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2I UBE2J1 UBE2L6 UBE2N UBE2W XRCC1
Entrez ID		26135	10210
HPRD ID		09570	11642
Ensembl ID		ENSG00000142864	ENSG00000197579
Uniprot IDs		Q5VU21 Q8NC51	Q9NS56
PDB IDs		4V6X 6Z6M 6Z6N 8K2C 8UKB 8XSX 8XSY 8XSZ 8Y0W 8Y0X
Enriched GO Terms of Interacting Partners?		PML Body Positive Regulation Of Protein Sumoylation Protein Sumoylation SUMO Transferase Activity Regulation Of Protein Sumoylation SUMO Ligase Activity Transcription Coregulator Activity Regulation Of Post-translational Protein Modification Chromatin Organization Chromatin Remodeling Negative Regulation Of Gene Expression Symbiont-mediated Disruption Of Host Cell PML Body Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Proteolysis Regulation Of Protein Catabolic Process Protein Modification Process Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Enzyme Binding Positive Regulation Of Transcription By Glucose Negative Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Rhythmic Process Carbon Catabolite Regulation Of Transcription Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Metabolic Process Positive Regulation Of Post-translational Protein Modification Regulation Of Programmed Cell Death Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Macromolecule Metabolic Process Macromolecule Metabolic Process Positive Regulation Of Gene Expression, Epigenetic Regulation Of Primary Metabolic Process Regulation Of Glycolytic Process Regulation Of Protein Metabolic Process Regulation Of Gluconeogenesis Protein Modification By Small Protein Conjugation Regulation Of Transcription By Glucose Regulation Of Macromolecule Metabolic Process Cellular Response To Stress	Ubiquitin Conjugating Enzyme Activity Nucleus Proteolysis Involved In Protein Catabolic Process Post-translational Protein Modification Protein Modification By Small Protein Conjugation Protein Modification Process Protein Polyubiquitination Macromolecule Metabolic Process Nucleoplasm Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Ubiquitin Protein Ligase Binding DNA Metabolic Process Proteolysis Protein Ubiquitination Macromolecule Catabolic Process Regulation Of Macromolecule Metabolic Process DNA Repair Ubiquitin-protein Transferase Activity Protein Metabolic Process PML Body DNA Damage Response Regulation Of Metabolic Process Double-strand Break Repair Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Nuclear Body PML Body Organization Negative Regulation Of Biosynthetic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of TOR Signaling RNA Binding Cellular Response To Stress Protein K48-linked Ubiquitination Catabolic Process ATP Binding Nucleic Acid Metabolic Process Protein Tag Activity Protein Monoubiquitination DNA Recombination Negative Regulation Of Transcription By RNA Polymerase II Nuclear Body Organization Negative Regulation Of Nucleobase-containing Compound Metabolic Process TORC1 Signaling Cellular Response To Nutrient Levels Negative Regulation Of TORC1 Signaling Regulation Of Nucleobase-containing Compound Metabolic Process
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