TOPORS and SETX

Number of citations of the paper that reports this interaction (PubMedID 24244371)
56

Data Source:
BioGRID (two hybrid)

		TOPORS	SETX
Description		TOP1 binding arginine/serine rich protein, E3 ubiquitin ligase	senataxin
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Spindle Pole Gamma-tubulin Complex Nucleus Nucleoplasm Centriole PML Body Nuclear Speck Midbody Photoreceptor Connecting Cilium Ciliary Basal Body	Nuclear Chromosome Chromosome, Telomeric Region Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Nuclear Body Axon Growth Cone Cell Projection Intercellular Bridge
	Molecular Function	DNA Binding Antigen Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity SUMO Transferase Activity DNA Topoisomerase Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Nucleotide Binding Transcription Termination Site Sequence-specific DNA Binding DNA Binding DNA Helicase Activity RNA Binding Helicase Activity Protein Binding ATP Binding Hydrolase Activity Identical Protein Binding
	Biological Process	Protein Polyubiquitination DNA-templated Transcription Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination DNA Damage Response Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Retina Layer Formation Protein Sumoylation Protein Localization To Nucleus Photoreceptor Cell Outer Segment Organization Regulation Of Cell Population Proliferation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of DNA-templated Transcription Maintenance Of Protein Location In Nucleus Protein K48-linked Ubiquitination	DNA Repair Double-strand Break Repair DNA Recombination DNA-templated Transcription Termination Termination Of RNA Polymerase II Transcription MRNA Splice Site Recognition RNA Processing DNA Damage Response Spermatogenesis Nervous System Development Circadian Rhythm Positive Regulation Of Neuron Projection Development Cell Differentiation Positive Regulation Of RNA Splicing Cellular Response To Oxidative Stress Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process Positive Regulation Of Termination Of DNA-templated Transcription Cellular Response To Hydrogen Peroxide Positive Regulation Of DNA-templated Transcription Initiation Positive Regulation Of Termination Of RNA Polymerase II Transcription, Poly(A)-coupled
Pathways		SUMOylation of transcription cofactors SUMOylation of SUMOylation proteins SUMOylation of immune response proteins
Drugs
Diseases		Retinitis pigmentosa (RP)	Ataxia with ocular apraxia (AOA), including: Ataxia telangiectasia (AT); Ataxia telangiectasia like disorder (ATLD); Ataxia oculomotor apraxia type 1 (AOA1); Ataxia oculomotor apraxia type 2 (AOA2) Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease Distal hereditary motor neuropathies (dHMN)
GWAS		Early spontaneous preterm birth ( 31194736) Immune response to smallpox vaccine (IL-6) ( 22610502) Metabolite levels ( 23823483)	Current cigarettes per day in chronic obstructive pulmonary disease ( 29631575) Metabolite levels ( 23823483)
Interacting Genes		30 interacting genes: CASP8 CREBBP EPM2A HABP4 MTDH NKX3-1 PRMT1 RAD51 SATB1 SERBP1 SETX SIN3A SNIP1 SPOP SUMO1 SUMO2 TOP1 TP53 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2I UBE2J1 UBE2L6 UBE2N UBE2W XRCC1	15 interacting genes: BCYRN1 BRCA1 CHD3 EXOSC9 HIPK2 PIAS1 PTEN RNF10 SUMO1 SUMO2 TDG TOPORS UBA2 UBC UBE2I
Entrez ID		10210	23064
HPRD ID		11642	07622
Ensembl ID		ENSG00000197579	ENSG00000107290
Uniprot IDs		Q9NS56	Q7Z333
PDB IDs
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Nucleus Proteolysis Involved In Protein Catabolic Process Post-translational Protein Modification Protein Modification By Small Protein Conjugation Protein Modification Process Protein Polyubiquitination Macromolecule Metabolic Process Nucleoplasm Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Ubiquitin Protein Ligase Binding DNA Metabolic Process Proteolysis Protein Ubiquitination Macromolecule Catabolic Process Regulation Of Macromolecule Metabolic Process DNA Repair Ubiquitin-protein Transferase Activity Protein Metabolic Process PML Body DNA Damage Response Regulation Of Metabolic Process Double-strand Break Repair Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Nuclear Body PML Body Organization Negative Regulation Of Biosynthetic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of TOR Signaling RNA Binding Cellular Response To Stress Protein K48-linked Ubiquitination Catabolic Process ATP Binding Nucleic Acid Metabolic Process Protein Tag Activity Protein Monoubiquitination DNA Recombination Negative Regulation Of Transcription By RNA Polymerase II Nuclear Body Organization Negative Regulation Of Nucleobase-containing Compound Metabolic Process TORC1 Signaling Cellular Response To Nutrient Levels Negative Regulation Of TORC1 Signaling Regulation Of Nucleobase-containing Compound Metabolic Process	PML Body Protein Sumoylation Protein Modification By Small Protein Conjugation SUMO Transferase Activity Small Protein Activating Enzyme Binding Presynaptic Cytosol Post-translational Protein Modification Postsynaptic Cytosol Protein Modification Process Protein Tag Activity Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Nucleoplasm Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Ubiquitin Protein Ligase Binding Protein Metabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Macromolecule Metabolic Process PML Body Organization Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Proteolysis Positive Regulation Of Nucleobase-containing Compound Metabolic Process Enzyme Binding RNA Binding Positive Regulation Of Biosynthetic Process Positive Regulation Of Proteolysis SUMO Binding Nucleus Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage DNA Damage Response Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Sumoylation Regulation Of Macromolecule Metabolic Process XY Body Transcription Cis-regulatory Region Binding Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Glutamatergic Synapse Regulation Of Macromolecule Biosynthetic Process
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