SERBP1 and TDG

Number of citations of the paper that reports this interaction (PMID 16679534)
6

Data Source:
HPRD (two hybrid, in vivo)

		SERBP1	TDG
Gene Name		SERPINE1 mRNA binding protein 1	thymine-DNA glycosylase
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane Membrane Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome	Nucleus Nucleoplasm Plasma Membrane PML Body
	Molecular Function	MRNA 3'-UTR Binding Protein Binding Poly(A) RNA Binding	RNA Polymerase II Transcription Cofactor Activity Damaged DNA Binding Double-stranded DNA Binding Protein Kinase C Binding Protein Binding Transcription Factor Binding Pyrimidine-specific Mismatch Base Pair DNA N-glycosylase Activity DNA N-glycosylase Activity Protein Domain Specific Binding Mismatched DNA Binding SUMO Binding Protein Homodimerization Activity Structure-specific DNA Binding
	Biological Process	Regulation Of Apoptotic Process Regulation Of MRNA Stability	Negative Regulation Of Transcription From RNA Polymerase II Promoter DNA Repair Base-excision Repair Base-excision Repair, AP Site Formation Mismatch Repair Transcription From RNA Polymerase II Promoter Embryo Development Gene Expression Chromatin Modification Negative Regulation Of Protein Binding Oxidative DNA Demethylation Negative Regulation Of Chromatin Binding Regulation Of Gene Expression, Epigenetic Depyrimidination DNA Demethylation
Pathways			Base Excision Repair TET1,2,3 and TDG demethylate DNA Epigenetic regulation of gene expression Depyrimidination Resolution of AP sites via the multiple-nucleotide patch replacement pathway Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected pyrimidine Base-Excision Repair, AP Site Formation Removal of DNA patch containing abasic residue Resolution of AP sites via the single-nucleotide replacement pathway Base-free sugar-phosphate removal via the single-nucleotide replacement pathway Displacement of DNA glycosylase by APE1 Resolution of Abasic Sites (AP sites)
Drugs
Diseases
GWAS		Crohn's disease ( 22412388)
Protein-Protein Interactions		20 interactors: APP CHD3 CSNK2A1 DAXX FBXO25 FXYD3 ITFG1 KAT2B PCAP PIAS1 PIAS3 PIAS4 PRMT8 TDG TERT TOPORS UBA2 UPF2 VAV2 VIM	30 interactors: AR CREBBP DDX39B DNMT3B DTL EP300 ESR1 IKZF1 JUN JUNB NKX2-1 NR3C1 PCNA PGR PML RAD23B RXRA SERBP1 SKIL SMAD4 SNIP1 SUMO1 SUMO2 SUMO3 THRA TP53 TP73 UBE2I VDR XPC
Entrez ID		26135	6996
HPRD ID		09570	03251
Ensembl ID		ENSG00000142864	ENSG00000139372
Uniprot IDs		Q5VU21 Q63HR1 Q8NC51	B4DI29 B4E127 Q13569
PDB IDs		3J3A	1WYW 2D07 2RBA 3UFJ 3UO7 3UOB 4FNC 4JGC
Enriched GO Terms of Interacting Partners?		Protein Sumoylation Peptidyl-lysine Modification Positive Regulation Of Protein Sumoylation RNA Metabolic Process Regulation Of Gene Expression Regulation Of Protein Sumoylation Positive Regulation Of Metabolic Process Gene Expression Regulation Of Metabolic Process RNA Biosynthetic Process Peptidyl-amino Acid Modification Chromatin Modification Protein Modification By Small Protein Conjugation Chromatin Organization Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Transcription, DNA-templated Positive Regulation Of Protein Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Protein Modification Process Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Cellular Protein Metabolic Process Apoptotic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Programmed Cell Death Negative Regulation Of Cellular Metabolic Process Chromosome Organization Positive Regulation Of Gene Expression Cellular Macromolecule Biosynthetic Process Cell Death Death Regulation Of Protein Metabolic Process Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Catalytic Activity Regulation Of Protein Binding Positive Regulation Of Cellular Metabolic Process Cellular Protein Metabolic Process Intracellular Receptor Signaling Pathway Androgen Receptor Signaling Pathway Positive Regulation Of Protein Modification Process Regulation Of Apoptotic Process Cellular Metabolic Process Regulation Of Cell Death Negative Regulation Of Production Of SiRNA Involved In RNA Interference	Negative Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Biosynthetic Process Positive Regulation Of Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process DNA-templated Transcription, Initiation Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Gene Expression Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Transcription, DNA-templated Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription, DNA-templated Gland Development Response To Organic Substance Regulation Of Gene Expression Regulation Of Nucleic Acid-templated Transcription Nitrogen Compound Metabolic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of RNA Metabolic Process RNA Metabolic Process Regulation Of Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Cellular Response To Organic Substance Gene Expression Epithelium Development Transcription, DNA-templated Steroid Hormone Mediated Signaling Pathway RNA Biosynthetic Process Tissue Development Negative Regulation Of Cellular Metabolic Process Intracellular Receptor Signaling Pathway Hormone-mediated Signaling Pathway Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Cellular Metabolic Process Organ Development Regulation Of Cellular Process Cellular Response To Steroid Hormone Stimulus Response To Lipid Response To Abiotic Stimulus
Tagcloud ?		9q altered cgi contexts experimentally explain familiar functionally give habp4 haplotype hek293t identity inducer insights ki knockdown link microchip overexpression paralogs prompting qrt shared similarity sirna thapsigargin transcriptome tumorigenic	cytosines deamination dr1 dr5 element glycosylase harboring helix heterodimers initiates mapping methylated mismatch mismatches nucleotides pleiotropic potentiated rar repeat retinoid retinoids rxr screen spaced spontaneous thymine transactivation transfection yeast
Tagcloud (Difference) ?		9q altered cgi contexts experimentally explain familiar functionally give habp4 haplotype hek293t identity inducer insights ki knockdown link microchip overexpression paralogs prompting qrt shared similarity sirna thapsigargin transcriptome tumorigenic	cytosines deamination dr1 dr5 element glycosylase harboring helix heterodimers initiates mapping methylated mismatch mismatches nucleotides pleiotropic potentiated rar repeat retinoid retinoids rxr screen spaced spontaneous thymine transactivation transfection yeast
Tagcloud (Intersection) ?