SERBP1 and PRMT8

Number of citations of the paper that reports this interaction (PubMedID 37223481)
35

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		SERBP1	PRMT8
Description		SERPINE1 mRNA binding protein 1	protein arginine methyltransferase 8
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Membrane Perinuclear Region Of Cytoplasm Extracellular Exosome	Nucleus Plasma Membrane Cytoplasmic Side Of Plasma Membrane Membrane
	Molecular Function	RNA Binding MRNA 3'-UTR Binding Protein Binding Translation Repressor Activity SUMO Binding Ribosome Binding Cadherin Binding Translation Elongation Factor Binding	Protein Binding Methyltransferase Activity S-adenosylmethionine-dependent Methyltransferase Activity Protein-arginine N-methyltransferase Activity Transferase Activity Enzyme Binding Protein-arginine Omega-N Monomethyltransferase Activity Protein-arginine Omega-N Asymmetric Methyltransferase Activity Histone Methyltransferase Activity Identical Protein Binding Protein Homodimerization Activity Histone H4 Methyltransferase Activity S-adenosyl-L-methionine Binding
	Biological Process	Regulation Of Translation Negative Regulation Of Translation PML Body Organization Regulation Of MRNA Stability Ribosome Hibernation	Chromatin Remodeling Regulation Of DNA-templated Transcription Protein Methylation Peptidyl-arginine Methylation Methylation Protein Homooligomerization Regulation Of Modification Of Postsynaptic Actin Cytoskeleton
Pathways
Drugs
Diseases
GWAS		Bone mineral density (hip) ( 30172743) Carotid plaque burden ( 28282560) Crohn's disease ( 22412388 28067908) DHEAS levels ( 34748635) Inflammatory bowel disease ( 28067908) Primary biliary cholangitis ( 26394269) Ulcerative colitis ( 28067908)	Cardiac Troponin-T levels ( 31014085) Erosive tooth wear (severe vs non-severe) ( 29898447) Erosive tooth wear (severe vs none or mild) ( 29898447) Gut microbiota (bacterial taxa) ( 27723756) HDL cholesterol ( 19060911)
Interacting Genes		27 interacting genes: - APP CHD3 CSNK2A1 DANCR DAXX ESR1 FBXO25 FXYD3 H19 KAT2B LINC00624 OGT PIAS1 PIAS3 PIAS4 PICK1 PRMT8 TDG TERT TOPORS UBA2 UPF2 USP7 VAV2 VIM WEE2-AS1	20 interacting genes: CARM1 CEP162 COIL DCAF8 FBL FYN GPATCH2L H4C1 KRTAP6-3 OFCC1 PIK3R1 PLCG1 PPARA PRMT1 PRMT2 SERBP1 TNPO2 UBL5 VHL ZNF451
Entrez ID		26135	56341
HPRD ID		09570	11029
Ensembl ID		ENSG00000142864	ENSG00000111218
Uniprot IDs		Q5VU21 Q8NC51	Q59GT2 Q9NR22
PDB IDs		4V6X 6Z6M 6Z6N 8K2C 8UKB 8XSX 8XSY 8XSZ 8Y0W 8Y0X	4X41 5DST
Enriched GO Terms of Interacting Partners?		PML Body Positive Regulation Of Protein Sumoylation Protein Sumoylation SUMO Transferase Activity Regulation Of Protein Sumoylation SUMO Ligase Activity Transcription Coregulator Activity Regulation Of Post-translational Protein Modification Chromatin Organization Chromatin Remodeling Negative Regulation Of Gene Expression Symbiont-mediated Disruption Of Host Cell PML Body Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Proteolysis Regulation Of Protein Catabolic Process Protein Modification Process Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Enzyme Binding Positive Regulation Of Transcription By Glucose Negative Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Rhythmic Process Carbon Catabolite Regulation Of Transcription Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Metabolic Process Positive Regulation Of Post-translational Protein Modification Regulation Of Programmed Cell Death Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Macromolecule Metabolic Process Macromolecule Metabolic Process Positive Regulation Of Gene Expression, Epigenetic Regulation Of Primary Metabolic Process Regulation Of Glycolytic Process Regulation Of Protein Metabolic Process Regulation Of Gluconeogenesis Protein Modification By Small Protein Conjugation Regulation Of Transcription By Glucose Regulation Of Macromolecule Metabolic Process Cellular Response To Stress	Protein-arginine Omega-N Asymmetric Methyltransferase Activity Protein-arginine N-methyltransferase Activity Histone Methyltransferase Activity Neurotrophin TRKA Receptor Binding Methyltransferase Activity Cajal Body Nucleus Negative Regulation Of Inflammatory Response Methylation Negative Regulation Of Developmental Process Protein Methyltransferase Activity Phosphatidylinositol 3-kinase Binding Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Negative Regulation Of Myeloid Cell Differentiation Negative Regulation Of Megakaryocyte Differentiation Macromolecule Methylation Negative Regulation Of Defense Response Protein Modification Process Nucleoplasm Chromatin Remodeling U6 SnRNA 2'-O-ribose Methyltransferase Activity Regulation Of Apoptotic Process Regulation Of Reactive Oxygen Species Biosynthetic Process Negative Regulation Of Inflammatory Response To Antigenic Stimulus Cellular Response To Glycine Negative Regulation Of Reactive Oxygen Species Metabolic Process Response To Singlet Oxygen Protein Methylation Histone H3R8 Methyltransferase Activity GATOR1 Complex Binding Negative Regulation Of Cell Differentiation Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Megakaryocyte Differentiation Positive Regulation Of Transformation Of Host Cell By Virus Regulation Of Developmental Process Regulation Of Programmed Cell Death DNA-binding Transcription Factor Binding Regulation Of Inflammatory Response
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