SERBP1 and PIAS3

Number of citations of the paper that reports this interaction (PubMedID 16679534)
0

Data Source:
HPRD (two hybrid)

		SERBP1	PIAS3
Description		SERPINE1 mRNA binding protein 1	protein inhibitor of activated STAT 3
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Membrane Perinuclear Region Of Cytoplasm Extracellular Exosome	Chromatin Nucleus Nucleoplasm Cytoplasm Nuclear Speck Glutamatergic Synapse Presynaptic Cytosol Postsynaptic Cytosol
	Molecular Function	RNA Binding MRNA 3'-UTR Binding Protein Binding Translation Repressor Activity SUMO Binding Ribosome Binding Cadherin Binding Translation Elongation Factor Binding	Transcription Coregulator Activity Protein Binding Zinc Ion Binding Transferase Activity SUMO Transferase Activity Metal Ion Binding SUMO Ligase Activity
	Biological Process	Regulation Of Translation Negative Regulation Of Translation PML Body Organization Regulation Of MRNA Stability Ribosome Hibernation	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Gene Expression Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Protein Sumoylation Negative Regulation Of Protein Sumoylation Positive Regulation Of Protein Sumoylation Negative Regulation Of Osteoclast Differentiation Negative Regulation Of DNA-templated Transcription Regulation Of Macromolecule Metabolic Process
Pathways			SUMOylation of transcription factors SUMOylation of transcription cofactors SUMOylation of intracellular receptors SUMOylation of DNA replication proteins SUMOylation of immune response proteins Formation of Incision Complex in GG-NER
Drugs
Diseases
GWAS		Bone mineral density (hip) ( 30172743) Carotid plaque burden ( 28282560) Crohn's disease ( 22412388 28067908) DHEAS levels ( 34748635) Inflammatory bowel disease ( 28067908) Primary biliary cholangitis ( 26394269) Ulcerative colitis ( 28067908)
Interacting Genes		27 interacting genes: - APP CHD3 CSNK2A1 DANCR DAXX ESR1 FBXO25 FXYD3 H19 KAT2B LINC00624 OGT PIAS1 PIAS3 PIAS4 PICK1 PRMT8 TDG TERT TOPORS UBA2 UPF2 USP7 VAV2 VIM WEE2-AS1	61 interacting genes: AR ATF7IP CARHSP1 CBS CREBBP CREM EP300 ERG ESR1 ESR2 FOXP2 GEMIN4 GFI1 GLUL HABP4 HDAC1 HMGA2 MITF MORC3 NCOA2 NR3C2 NRIP1 OPN1LW PGR PLIN3 PPP1CA PRPF40A PSMC1 RAC1 RELA REX1BD SATB1 SENP1 SERBP1 SERPINA10 SIAH1 SIAH2 SKIL SMAD2 SMAD3 SMAD4 SNAI2 SNCA SNIP1 SPOP SREBF2 STAT3 STIP1 SUMO1 SUMO2 SUMO3 TBP TRIM27 TRIM32 TRIM55 TRIM63 UBA1 UBE2I ZFHX3 ZMIZ1 ZMIZ2
Entrez ID		26135	10401
HPRD ID		09570	09068
Ensembl ID		ENSG00000142864	ENSG00000131788
Uniprot IDs		Q5VU21 Q8NC51	B3KNI3 Q9Y6X2
PDB IDs		4V6X 6Z6M 6Z6N 8K2C 8UKB 8XSX 8XSY 8XSZ 8Y0W 8Y0X	4MVT
Enriched GO Terms of Interacting Partners?		PML Body Positive Regulation Of Protein Sumoylation Protein Sumoylation SUMO Transferase Activity Regulation Of Protein Sumoylation SUMO Ligase Activity Transcription Coregulator Activity Regulation Of Post-translational Protein Modification Chromatin Organization Chromatin Remodeling Negative Regulation Of Gene Expression Symbiont-mediated Disruption Of Host Cell PML Body Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Proteolysis Regulation Of Protein Catabolic Process Protein Modification Process Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Enzyme Binding Positive Regulation Of Transcription By Glucose Negative Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Rhythmic Process Carbon Catabolite Regulation Of Transcription Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Metabolic Process Positive Regulation Of Post-translational Protein Modification Regulation Of Programmed Cell Death Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Macromolecule Metabolic Process Macromolecule Metabolic Process Positive Regulation Of Gene Expression, Epigenetic Regulation Of Primary Metabolic Process Regulation Of Glycolytic Process Regulation Of Protein Metabolic Process Regulation Of Gluconeogenesis Protein Modification By Small Protein Conjugation Regulation Of Transcription By Glucose Regulation Of Macromolecule Metabolic Process Cellular Response To Stress	Negative Regulation Of DNA-templated Transcription Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Biosynthetic Process Nucleus Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Chromatin Negative Regulation Of Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Negative Regulation Of Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Primary Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Nucleoplasm Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Gene Expression RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Transcription Regulator Complex Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Enzyme Binding DNA-binding Transcription Factor Activity Transcription Coactivator Binding Protein Sumoylation Positive Regulation Of Macromolecule Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Transcription Cis-regulatory Region Binding Positive Regulation Of Biosynthetic Process Estrogen Response Element Binding Positive Regulation Of Macromolecule Biosynthetic Process Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Chromatin Binding Rhythmic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific SMAD Protein Complex PML Body Sequence-specific DNA Binding Regulation Of MiRNA Transcription Nuclear Steroid Receptor Activity Protein Modification By Small Protein Conjugation
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