FARS2 and TADA2A

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		FARS2	TADA2A
Description		phenylalanyl-tRNA synthetase 2, mitochondrial	transcriptional adaptor 2A
Image
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Matrix	SAGA Complex Nucleus Nucleoplasm Chromosome SAGA-type Complex Mitotic Spindle ATAC Complex
	Molecular Function	TRNA Binding Nucleotide Binding Aminoacyl-tRNA Ligase Activity Phenylalanine-tRNA Ligase Activity Protein Binding ATP Binding Ligase Activity	DNA Binding Chromatin Binding Transcription Coactivator Activity Histone Acetyltransferase Activity Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Translation TRNA Aminoacylation For Protein Translation Phenylalanyl-tRNA Aminoacylation TRNA Processing TRNA Aminoacylation	Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-templated Transcription Regulation Of Embryonic Development Regulation Of Cell Division Regulation Of Cell Cycle
Pathways		Mitochondrial tRNA aminoacylation	HATs acetylate histones Formation of WDR5-containing histone-modifying complexes
Drugs		Phenylalanine
Diseases
GWAS		Change in glucose in response to thiazide diuretic treatment in hypertension ( 29523524) Copper levels ( 26025379) Height ( 28552196) JT interval (sulfonylurea treatment interaction) ( 27958378) Metabolite levels ( 23823483) Obesity (early onset extreme) ( 23563609) Subjective response to placebo treatment in childhood asthma (change in cough/wheeze) ( 31557306)	Hip bone mineral density and total body fat mass (bivariate analysis) ( 32963334) Monocyte percentage of white cells ( 32888494) Ovarian cancer ( 23535730) Plateletcrit ( 32888494) White blood cell count ( 32888494)
Interacting Genes		68 interacting genes: ADAMTSL4 AGTRAP AJUBA AP1B1 APPL1 BACH2 BAG4 BANP BEX5 CALCOCO2 CBY2 CCDC152 CDCA4 CMTM5 CYSRT1 DGAT2L6 DPH2 DVL3 FHL5 FKBP7 FSD2 GRB10 HIGD1C HMBOX1 HOMEZ IKZF3 ISY1-RAB43 KCNF1 KCTD17 KRT13 KRT31 KRT34 KRT40 KRTAP1-1 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP3-3 MAN1C1 MDFI MESD MID2 MKRN3 MORN3 NFKBID NOTCH2NLA PCSK5 PPP1R16B RCBTB2 RIMBP3C SPRY1 STX11 SYP TADA2A TEPSIN TFCP2 TPM2 TRAF2 TRIM27 TRIM54 TRIP6 YIF1A ZNF438 ZNF500 ZNF526 ZNF655	49 interacting genes: AIRIM ARNT2 CCDC116 CCDC134 CCHCR1 CDCA7L EIF4E2 EXOC8 FAM107A FANCG FARS2 FBF1 GPSM3 HGS HNRNPLL KAT2A KLC4 KLHL38 KPNA2 LMO1 MAGOH MAGOHB MCPH1 MFAP1 MKRN3 MTX2 MYC NFE2L2 NOL4L-DT NR3C1 PPP1R16B PRKAB2 PRPF31 QARS1 RNF6 RTL8B SF3A3 TADA3 TCF3 TEKT4 THOC1 TTC23 TTC9C VPS25 ZCCHC12 ZFYVE26 ZNF417 ZNF564 ZNF688
Entrez ID		10667	6871
HPRD ID		09946	03784
Ensembl ID		ENSG00000145982	ENSG00000276234
Uniprot IDs		O95363	A0A024R0Y4 A0A087WWR4 A0A0S2Z4G1 B3KU13 O75478
PDB IDs		3CMQ 3HFV 3TEG 3TUP 5MGH 5MGU 5MGV 5MGW 8P8X	1X41
Enriched GO Terms of Interacting Partners?		Keratin Filament Intermediate Filament Identical Protein Binding Protein Binding Structural Constituent Of Skin Epidermis Intermediate Filament Organization	Protein Binding U2-type Precatalytic Spliceosome Nuclear Speck Exon-exon Junction Subcomplex Mago-y14 Nucleus U2-type Spliceosomal Complex Spliceosomal Complex MRNA Splicing, Via Spliceosome MRNA Processing Negative Regulation Of Stress-activated MAPK Cascade Membrane Fission RNA Splicing, Via Transesterification Reactions Negative Regulation Of Stress-activated Protein Kinase Signaling Cascade Cytoplasm Centrosome Nuclear Export RNA Splicing ATAC Complex Nuclear Transport Nucleocytoplasmic Transport Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?