FARS2 and RCBTB2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid, two hybrid)

		FARS2	RCBTB2
Description		phenylalanyl-tRNA synthetase 2, mitochondrial	RCC1 and BTB domain containing protein 2
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Matrix	Acrosomal Vesicle Cytoplasm Cytoplasmic Vesicle
	Molecular Function	TRNA Binding Nucleotide Binding Aminoacyl-tRNA Ligase Activity Phenylalanine-tRNA Ligase Activity Protein Binding ATP Binding Ligase Activity	Guanyl-nucleotide Exchange Factor Activity Protein Binding
	Biological Process	Translation TRNA Aminoacylation For Protein Translation Phenylalanyl-tRNA Aminoacylation TRNA Processing TRNA Aminoacylation	Liver Development Cell Population Proliferation Lymph Node Development Spleen Development Digestive Tract Development
Pathways		Mitochondrial tRNA aminoacylation
Drugs		Phenylalanine
Diseases
GWAS		Change in glucose in response to thiazide diuretic treatment in hypertension ( 29523524) Copper levels ( 26025379) Height ( 28552196) JT interval (sulfonylurea treatment interaction) ( 27958378) Metabolite levels ( 23823483) Obesity (early onset extreme) ( 23563609) Subjective response to placebo treatment in childhood asthma (change in cough/wheeze) ( 31557306)	Metabolite levels ( 23823483)
Interacting Genes		68 interacting genes: ADAMTSL4 AGTRAP AJUBA AP1B1 APPL1 BACH2 BAG4 BANP BEX5 CALCOCO2 CBY2 CCDC152 CDCA4 CMTM5 CYSRT1 DGAT2L6 DPH2 DVL3 FHL5 FKBP7 FSD2 GRB10 HIGD1C HMBOX1 HOMEZ IKZF3 ISY1-RAB43 KCNF1 KCTD17 KRT13 KRT31 KRT34 KRT40 KRTAP1-1 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP3-3 MAN1C1 MDFI MESD MID2 MKRN3 MORN3 NFKBID NOTCH2NLA PCSK5 PPP1R16B RCBTB2 RIMBP3C SPRY1 STX11 SYP TADA2A TEPSIN TFCP2 TPM2 TRAF2 TRIM27 TRIM54 TRIP6 YIF1A ZNF438 ZNF500 ZNF526 ZNF655	8 interacting genes: COPS4 FARS2 MORF4L1 PDE4B PLA2G6 RBBP9 TMEM132D UBE2I
Entrez ID		10667	1102
HPRD ID		09946	04631
Ensembl ID		ENSG00000145982	ENSG00000136161
Uniprot IDs		O95363	B4DWG0 B4E372 O95199 Q59FB7
PDB IDs		3CMQ 3HFV 3TEG 3TUP 5MGH 5MGU 5MGV 5MGW 8P8X
Enriched GO Terms of Interacting Partners?		Keratin Filament Intermediate Filament Identical Protein Binding Protein Binding Structural Constituent Of Skin Epidermis Intermediate Filament Organization	Serine Hydrolase Activity
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