ERC2 and RIMS1

Number of citations of the paper that reports this interaction (PMID 12163476)
44

Data Source:
HPRD (in vivo, in vitro)

		ERC2	RIMS1
Gene Name		ELKS/RAB6-interacting/CAST family member 2	regulating synaptic membrane exocytosis 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytoskeleton Cell Junction Growth Cone Presynaptic Membrane Presynaptic Active Zone	Cytosol Plasma Membrane Cell Junction Presynaptic Membrane Presynaptic Active Zone
	Molecular Function	Protein Binding	Small GTPase Regulator Activity Protein Binding Rab GTPase Binding Ion Channel Binding Poly(A) RNA Binding Metal Ion Binding
	Biological Process		Protein Complex Assembly Intracellular Protein Transport Synaptic Transmission Neurotransmitter Secretion Visual Perception Positive Regulation Of Gene Expression Glutamate Secretion Synaptic Vesicle Exocytosis Calcium Ion-dependent Exocytosis Regulated Secretory Pathway Secretion Regulation Of Neurotransmitter Secretion Regulation Of Long-term Neuronal Synaptic Plasticity Calcium Ion-dependent Exocytosis Of Neurotransmitter Regulation Of Catalytic Activity Response To Stimulus Membrane Fusion Positive Regulation Of Inhibitory Postsynaptic Membrane Potential Positive Regulation Of Excitatory Postsynaptic Membrane Potential
Pathways			Dopamine Neurotransmitter Release Cycle Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle Serotonin Neurotransmitter Release Cycle GABA synthesis, release, reuptake and degradation Glutamate Neurotransmitter Release Cycle Transmission across Chemical Synapses
Drugs
Diseases
GWAS		Bipolar disorder and schizophrenia ( 21057379) Hip geometry ( 17903296)	Cognitive performance ( 20125193)
Protein-Protein Interactions		8 interactors: BSN MYB PCLO PPFIA1 PPFIA2 PPFIA3 PPFIA4 RIMS1	15 interactors: CACNA1B CACNA1C CAMK2A ERC1 ERC2 RAB10 RAB26 RAB27A RAB37 RAB3A SNAP25 STX1A SYT1 UNC13B YWHAH
Entrez ID		26059	22999
HPRD ID		10810	09435
Ensembl ID		ENSG00000187672	ENSG00000079841
Uniprot IDs		O15083	B7Z7W2 B7Z9Z3 Q3ZCW0 Q86UR5
PDB IDs			2CSS
Enriched GO Terms of Interacting Partners?		Glutamate Secretion Neurotransmitter Secretion Regulation Of Neurotransmitter Levels Neurotransmitter Transport Acid Secretion Dicarboxylic Acid Transport Synaptic Transmission Amino Acid Transport Cell-cell Signaling Secretion By Cell Secretion Carboxylic Acid Transport Organic Acid Transport Organic Anion Transport Anion Transport Ion Transport Establishment Of Localization In Cell Cellular Localization Transport Synaptic Vesicle Exocytosis Regulation Of Neuronal Synaptic Plasticity Signaling Cell Communication Synaptic Vesicle Transport Regulation Of Synaptic Plasticity Cell-matrix Adhesion Positive Regulation Of Inhibitory Postsynaptic Membrane Potential Establishment Of Vesicle Localization Vesicle Localization Cell-substrate Adhesion Calcium Ion-dependent Exocytosis Of Neurotransmitter Negative Regulation Of Stress Fiber Assembly Regulation Of Cellular Localization Negative Regulation Of Actin Filament Bundle Assembly Positive Regulation Of Histone H3-K9 Methylation Regulation Of Short-term Neuronal Synaptic Plasticity Regulation Of Synaptic Transmission Regulation Of Inhibitory Postsynaptic Membrane Potential Negative Regulation Of Establishment Of Protein Localization To Plasma Membrane Establishment Of Organelle Localization Exocytosis Positive Regulation Of Histone H3-K4 Methylation Negative Regulation Of Protein Localization To Plasma Membrane CAMP-mediated Signaling Regulation Of Histone H3-K4 Methylation Organelle Localization Cellular Response To Interleukin-6 Positive Regulation Of T-helper Cell Differentiation Cyclic-nucleotide-mediated Signaling Regulation Of Long-term Neuronal Synaptic Plasticity	Vesicle Docking Membrane Docking Vesicle Docking Involved In Exocytosis Secretion By Cell Exocytosis Establishment Of Localization In Cell Secretion Regulation Of Secretion Regulation Of Cellular Localization Regulation Of Exocytosis Cellular Localization Glutamate Secretion Synaptic Transmission Regulation Of Vesicle-mediated Transport Vesicle-mediated Transport Neurotransmitter Secretion Synaptic Vesicle Transport Protein Secretion Synaptic Vesicle Exocytosis Regulation Of Neurotransmitter Levels Positive Regulation Of Exocytosis Rab Protein Signal Transduction Regulation Of Synaptic Transmission Acid Secretion Neurotransmitter Transport Cell-cell Signaling Transport Establishment Of Vesicle Localization Dicarboxylic Acid Transport Intracellular Transport Vesicle Localization Signaling Cell Communication Synaptic Vesicle Docking Protein Transport Establishment Of Organelle Localization Establishment Of Protein Localization Amino Acid Transport Regulation Of Synaptic Plasticity Regulation Of Neurotransmitter Secretion Organelle Localization Positive Regulation Of Transport Ras Protein Signal Transduction Intracellular Signal Transduction Protein Localization Membrane Organization Intracellular Protein Transport Regulation Of Membrane Potential Positive Regulation Of Synaptic Transmission Membrane Depolarization
Tagcloud ?			abi3bp angioedema arachidonic associations aua bicc1 chinese clusters col24a1 entity fbxl7 galnac genome han hlf hypersensitivity intolerance nsaid nsaids rad51l rad51l1 reached scan spanish suffering suggestive t13 unrelated urticaria
Tagcloud (Difference) ?			abi3bp angioedema arachidonic associations aua bicc1 chinese clusters col24a1 entity fbxl7 galnac genome han hlf hypersensitivity intolerance nsaid nsaids rad51l rad51l1 reached scan spanish suffering suggestive t13 unrelated urticaria
Tagcloud (Intersection) ?