RIMS1 and STX1A

Number of citations of the paper that reports this interaction (PMID 11438522)
7

Data Source:
HPRD (in vitro)

		RIMS1	STX1A
Gene Name		regulating synaptic membrane exocytosis 1	syntaxin 1A (brain)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Plasma Membrane Cell Junction Presynaptic Membrane Presynaptic Active Zone	Extracellular Region Cytosol Plasma Membrane Synaptic Vesicle Endomembrane System Integral Component Of Membrane Cell Junction Secretory Granule Synaptic Vesicle Membrane SNARE Complex Actomyosin Neuron Projection Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II Complex Synaptobrevin 2-SNAP-25-syntaxin-1a Complex
	Molecular Function	Small GTPase Regulator Activity Protein Binding Rab GTPase Binding Ion Channel Binding Poly(A) RNA Binding Metal Ion Binding	SNARE Binding Glycoprotein Binding SNAP Receptor Activity Protein Binding Myosin Binding Calcium Channel Inhibitor Activity Chloride Channel Inhibitor Activity Kinase Binding Protein Domain Specific Binding Protein Binding, Bridging Myosin Head/neck Binding ATP-dependent Protein Binding Protein Heterodimerization Activity Protein N-terminus Binding Calcium-dependent Protein Binding
	Biological Process	Protein Complex Assembly Intracellular Protein Transport Synaptic Transmission Neurotransmitter Secretion Visual Perception Positive Regulation Of Gene Expression Glutamate Secretion Synaptic Vesicle Exocytosis Calcium Ion-dependent Exocytosis Regulated Secretory Pathway Secretion Regulation Of Neurotransmitter Secretion Regulation Of Long-term Neuronal Synaptic Plasticity Calcium Ion-dependent Exocytosis Of Neurotransmitter Regulation Of Catalytic Activity Response To Stimulus Membrane Fusion Positive Regulation Of Inhibitory Postsynaptic Membrane Potential Positive Regulation Of Excitatory Postsynaptic Membrane Potential	Positive Regulation Of Neurotransmitter Secretion Energy Reserve Metabolic Process Intracellular Protein Transport Synaptic Transmission Neurotransmitter Secretion Pathogenesis Response To Gravity Regulation Of Synaptic Vesicle Priming Glutamate Secretion Synaptic Vesicle Docking Calcium Ion-dependent Exocytosis Synaptic Vesicle Fusion To Presynaptic Membrane Secretion By Cell Cellular Protein Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Exocytosis Vesicle Docking Regulation Of Insulin Secretion Positive Regulation Of Excitatory Postsynaptic Membrane Potential
Pathways		Dopamine Neurotransmitter Release Cycle Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle Serotonin Neurotransmitter Release Cycle GABA synthesis, release, reuptake and degradation Glutamate Neurotransmitter Release Cycle Transmission across Chemical Synapses	Dopamine Neurotransmitter Release Cycle Integration of energy metabolism Acetylcholine Neurotransmitter Release Cycle Regulation of insulin secretion Toxicity of botulinum toxin type C (BoNT/C) Norepinephrine Neurotransmitter Release Cycle GABA synthesis, release, reuptake and degradation Glutamate Neurotransmitter Release Cycle Peptide hormone metabolism Uptake and actions of bacterial toxins Neurotransmitter Release Cycle Insulin processing Serotonin Neurotransmitter Release Cycle Neurotoxicity of clostridium toxins Transmission across Chemical Synapses
Drugs
Diseases
GWAS		Cognitive performance ( 20125193)
Protein-Protein Interactions		15 interactors: CACNA1B CACNA1C CAMK2A ERC1 ERC2 RAB10 RAB26 RAB27A RAB37 RAB3A SNAP25 STX1A SYT1 UNC13B YWHAH	58 interactors: ABCC9 APBA1 ATP4B ATP6V1B1 CACNA1D CCSER2 CDK5 CFTR CPLX1 CSNK2A1 CSNK2A2 DAPK1 KCNB1 NAPA NAPB NSF PSMA3 RAB27A RIMS1 SCNN1A SCNN1B SCNN1G SDCBP SEPT2 SEPT5 SLC6A1 SLC6A2 SLC6A3 SLC6A4 SLC6A5 SLC6A9 SNAP23 SNAP25 SNAP29 SNPH STX8 STXBP1 STXBP2 STXBP5 STXBP6 SUMO1P1 SYT1 SYT4 SYT7 SYTL4 TRDMT1 TXLNA TXLNB UNC13B VAMP1 VAMP2 VAMP5 VAMP7 VAMP8 VAPB VIM VPS11 VPS18
Entrez ID		22999	6804
HPRD ID		09435	01721
Ensembl ID		ENSG00000079841	ENSG00000106089
Uniprot IDs		B7Z7W2 B7Z9Z3 Q3ZCW0 Q86UR5	A8MZ54 Q16623 Q75ME0
PDB IDs		2CSS
Enriched GO Terms of Interacting Partners?		Vesicle Docking Membrane Docking Vesicle Docking Involved In Exocytosis Secretion By Cell Exocytosis Establishment Of Localization In Cell Secretion Regulation Of Secretion Regulation Of Cellular Localization Regulation Of Exocytosis Cellular Localization Glutamate Secretion Synaptic Transmission Regulation Of Vesicle-mediated Transport Vesicle-mediated Transport Neurotransmitter Secretion Synaptic Vesicle Transport Protein Secretion Synaptic Vesicle Exocytosis Regulation Of Neurotransmitter Levels Positive Regulation Of Exocytosis Rab Protein Signal Transduction Regulation Of Synaptic Transmission Acid Secretion Neurotransmitter Transport Cell-cell Signaling Transport Establishment Of Vesicle Localization Dicarboxylic Acid Transport Intracellular Transport Vesicle Localization Signaling Cell Communication Synaptic Vesicle Docking Protein Transport Establishment Of Organelle Localization Establishment Of Protein Localization Amino Acid Transport Regulation Of Synaptic Plasticity Regulation Of Neurotransmitter Secretion Organelle Localization Positive Regulation Of Transport Ras Protein Signal Transduction Intracellular Signal Transduction Protein Localization Membrane Organization Intracellular Protein Transport Regulation Of Membrane Potential Positive Regulation Of Synaptic Transmission Membrane Depolarization	Exocytosis Secretion By Cell Neurotransmitter Transport Secretion Regulation Of Exocytosis Regulation Of Neurotransmitter Levels Transport Vesicle-mediated Transport Regulation Of Secretion Neurotransmitter Secretion Synaptic Transmission Cell-cell Signaling Regulation Of Vesicle-mediated Transport Establishment Of Localization In Cell Synaptic Vesicle Transport Synaptic Vesicle Exocytosis Cellular Localization Positive Regulation Of Exocytosis Regulation Of Cellular Localization Membrane Fusion Glutamate Secretion Establishment Of Vesicle Localization Vesicle Localization Ion Transport Vesicle Fusion Protein Transport Establishment Of Protein Localization Amino Acid Transport Vesicle Docking Organelle Fusion Membrane Docking Establishment Of Organelle Localization Membrane Organization Acid Secretion Vesicle Organization Positive Regulation Of Secretion Organelle Localization Protein Localization Monovalent Inorganic Cation Transport Anion Transport Dicarboxylic Acid Transport Regulated Secretory Pathway Metal Ion Transport Vesicle Docking Involved In Exocytosis Positive Regulation Of Transport Carboxylic Acid Transport Regulation Of Synaptic Transmission Organic Acid Transport Sodium Ion Transport Organic Anion Transport
Tagcloud ?		abi3bp angioedema arachidonic associations aua bicc1 chinese clusters col24a1 entity fbxl7 galnac genome han hlf hypersensitivity intolerance nsaid nsaids rad51l rad51l1 reached scan spanish suffering suggestive t13 unrelated urticaria	colitis colonized died h7 hemolytic hemorrhagic hus isogenic k3995 lysogenic o157 outbreak outbreaks phage phages rabbits reflects shiga spinach stec streptomycin stx2 stx2a stx2c succumbed toxin uremic virulence
Tagcloud (Difference) ?		abi3bp angioedema arachidonic associations aua bicc1 chinese clusters col24a1 entity fbxl7 galnac genome han hlf hypersensitivity intolerance nsaid nsaids rad51l rad51l1 reached scan spanish suffering suggestive t13 unrelated urticaria	colitis colonized died h7 hemolytic hemorrhagic hus isogenic k3995 lysogenic o157 outbreak outbreaks phage phages rabbits reflects shiga spinach stec streptomycin stx2 stx2a stx2c succumbed toxin uremic virulence
Tagcloud (Intersection) ?