ERC2 and PCLO

Number of citations of the paper that reports this interaction (PMID 14734538)
39

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, in vitro)

		ERC2	PCLO
Gene Name		ELKS/RAB6-interacting/CAST family member 2	piccolo presynaptic cytomatrix protein
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytoskeleton Cell Junction Growth Cone Presynaptic Membrane Presynaptic Active Zone	Cytoskeleton Synaptic Vesicle Postsynaptic Density Membrane Cell Junction Synapse Presynaptic Cytoskeletal Matrix Assembled At Active Zones Extracellular Vesicular Exosome
	Molecular Function	Protein Binding	Transporter Activity Calcium Ion Binding Profilin Binding Calcium-dependent Phospholipid Binding
	Biological Process		Cytoskeleton Organization Synaptic Vesicle Exocytosis Regulation Of Exocytosis CAMP-mediated Signaling Insulin Secretion
Pathways
Drugs
Diseases
GWAS		Bipolar disorder and schizophrenia ( 21057379) Hip geometry ( 17903296)	Major depressive disorder ( 21621269)
Protein-Protein Interactions		8 interactors: BSN MYB PCLO PPFIA1 PPFIA2 PPFIA3 PPFIA4 RIMS1	3 interactors: ERC2 GIT1 GIT2
Entrez ID		26059	27445
HPRD ID		10810	16078
Ensembl ID		ENSG00000187672	ENSG00000186472
Uniprot IDs		O15083	Q9Y6V0
PDB IDs			1UJD
Enriched GO Terms of Interacting Partners?		Glutamate Secretion Neurotransmitter Secretion Regulation Of Neurotransmitter Levels Neurotransmitter Transport Acid Secretion Dicarboxylic Acid Transport Synaptic Transmission Amino Acid Transport Cell-cell Signaling Secretion By Cell Secretion Carboxylic Acid Transport Organic Acid Transport Organic Anion Transport Anion Transport Ion Transport Establishment Of Localization In Cell Cellular Localization Transport Synaptic Vesicle Exocytosis Regulation Of Neuronal Synaptic Plasticity Signaling Cell Communication Synaptic Vesicle Transport Regulation Of Synaptic Plasticity Cell-matrix Adhesion Positive Regulation Of Inhibitory Postsynaptic Membrane Potential Establishment Of Vesicle Localization Vesicle Localization Cell-substrate Adhesion Calcium Ion-dependent Exocytosis Of Neurotransmitter Negative Regulation Of Stress Fiber Assembly Regulation Of Cellular Localization Negative Regulation Of Actin Filament Bundle Assembly Positive Regulation Of Histone H3-K9 Methylation Regulation Of Short-term Neuronal Synaptic Plasticity Regulation Of Synaptic Transmission Regulation Of Inhibitory Postsynaptic Membrane Potential Negative Regulation Of Establishment Of Protein Localization To Plasma Membrane Establishment Of Organelle Localization Exocytosis Positive Regulation Of Histone H3-K4 Methylation Negative Regulation Of Protein Localization To Plasma Membrane CAMP-mediated Signaling Regulation Of Histone H3-K4 Methylation Organelle Localization Cellular Response To Interleukin-6 Positive Regulation Of T-helper Cell Differentiation Cyclic-nucleotide-mediated Signaling Regulation Of Long-term Neuronal Synaptic Plasticity	Regulation Of ARF GTPase Activity Regulation Of ARF Protein Signal Transduction Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of Ras GTPase Activity Regulation Of Ras Protein Signal Transduction Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction Regulation Of GTPase Activity Behavioral Response To Pain Positive Regulation Of Hydrolase Activity Response To Pain Positive Regulation Of Catalytic Activity Regulation Of Cytokinesis Regulation Of Intracellular Signal Transduction Multicellular Organismal Response To Stress Ephrin Receptor Signaling Pathway Regulation Of Catalytic Activity Regulation Of Signal Transduction
Tagcloud ?			adcy axon betweenness bioinformatics circadian coefficients conservation ctnnb1 damaging databases deciphering ever exome gnal guidance hundreds illustrates integrating masked microenvironment mutated necessity otherwise percentages rps6ka3 speed tcga thousands workflow
Tagcloud (Difference) ?			adcy axon betweenness bioinformatics circadian coefficients conservation ctnnb1 damaging databases deciphering ever exome gnal guidance hundreds illustrates integrating masked microenvironment mutated necessity otherwise percentages rps6ka3 speed tcga thousands workflow
Tagcloud (Intersection) ?