ERC2 and BSN

Number of citations of the paper that reports this interaction (PubMedID 14734538)
38

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)
HPRD (in vivo, in vitro)

		ERC2	BSN
Description		ELKS/RAB6-interacting/CAST family member 2	bassoon presynaptic cytomatrix protein
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Growth Cone Presynaptic Membrane Cell Projection Synapse Presynaptic Active Zone Presynapse Presynaptic Active Zone Cytoplasmic Component Glutamatergic Synapse GABA-ergic Synapse	Nucleus Cytoplasm Cytoskeleton Synaptic Vesicle Cell Surface Postsynaptic Density Membrane Axon Dendrite Synaptic Vesicle Membrane Cytoplasmic Vesicle Cell Projection Organelle Neuron Projection Terminus Synapse Presynaptic Active Zone Cytoskeleton Of Presynaptic Active Zone Excitatory Synapse Cochlear Hair Cell Ribbon Synapse Schaffer Collateral - CA1 Synapse Presynapse Glutamatergic Synapse GABA-ergic Synapse
	Molecular Function	Protein Binding Structural Constituent Of Presynaptic Active Zone	Enzyme Inhibitor Activity Zinc Ion Binding Metal Ion Binding Structural Constituent Of Presynaptic Active Zone
	Biological Process	Synaptic Vesicle Priming Maintenance Of Presynaptic Active Zone Structure Regulation Of Presynaptic Cytosolic Calcium Ion Concentration Regulation Of Calcium-dependent Activation Of Synaptic Vesicle Fusion	Chemical Synaptic Transmission Protein Localization To Synapse Maintenance Of Presynaptic Active Zone Structure Modulation Of Chemical Synaptic Transmission Synaptic Vesicle Clustering Regulation Of Synaptic Vesicle Cycle Presynaptic Active Zone Assembly
Pathways			Sensory processing of sound by inner hair cells of the cochlea
Drugs
Diseases
GWAS		Acute lymphoblastic leukemia (childhood) ( 22076464) Adult body size ( 32376654) Alcohol dependence ( 24166409) Bipolar disorder and schizophrenia ( 21057379) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Chronotype ( 26955885) Cortical surface area (MOSTest) ( 32665545) Daytime sleep phenotypes ( 27126917) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Heel bone mineral density ( 30598549 28869591) Hip bone size ( 31053729) Hip circumference adjusted for BMI ( 34021172) Hip geometry ( 17903296) Intertrochanteric region size ( 31053729) Lateral thalamic nuclei volume ( 34006833) Lung function in never smokers (high FEV1 vs average FEV1) ( 26423011) Morning vs. evening chronotype ( 26955885 27494321) Night sleep phenotypes ( 27126917) Periodontitis (Mean PAL) ( 24024966) Post bronchodilator FEV1/FVC ratio ( 26634245) Refractive error ( 32231278) Sense of smell ( 26632684) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Tourette syndrome ( 30818990) Trochanter size ( 31053729)	A body shape index ( 34021172) Body mass index ( 26426971) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) C-reactive protein levels ( 30388399) Childhood ear infection ( 27182965 28928442) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Cognitive function ( 25644384) Coronary artery disease ( 33020668) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 21102463 17554300 28067908) Extremely high intelligence ( 29520040) Fasting glucose ( 34059833) General cognitive ability ( 29844566) Gut microbiota (functional units) ( 27694959) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494) Household income (MTAG) ( 31844048) Immature fraction of reticulocytes ( 32888494 27863252) Inflammatory bowel disease ( 28067908 23128233) Intelligence (MTAG) ( 29326435) Mean spheric corpuscular volume ( 32888494) Mood instability ( 31168069) Morning person ( 30696823) Prostate cancer ( 33293427) Refractive error ( 32231278) Regular attendance at a gym or sports club ( 29970889) Regular attendance at a religious group ( 29970889) Reticulocyte count ( 32888494) Self-rated health ( 27864402) Sleep duration (short sleep) ( 30846698) Smoking cessation ( 33082346) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 25082827 28067908 21297633) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		9 interacting genes: BSN MYB NRIP1 PCLO PPFIA1 PPFIA2 PPFIA3 PPFIA4 RIMS1	2 interacting genes: ERC2 USP7
Entrez ID		26059	8927
HPRD ID		10810	04933
Ensembl ID		ENSG00000187672	ENSG00000164061
Uniprot IDs		H7C4G9 O15083	Q9UPA5
PDB IDs
Enriched GO Terms of Interacting Partners?		Presynaptic Active Zone Synapse Organization Cell Junction Organization Maintenance Of Synapse Structure Structural Constituent Of Presynaptic Active Zone Maintenance Of Presynaptic Active Zone Structure Cell Junction Maintenance Presynaptic Active Zone Organization Cellular Component Maintenance Cytoskeleton Of Presynaptic Active Zone Synaptic Vesicle Exocytosis Presynaptic Active Zone Assembly Signal Release Organelle Localization Synapse Synaptic Vesicle Docking Presynaptic Active Zone Cytoplasmic Component Vesicle-mediated Transport In Synapse Synaptic Vesicle Clustering Regulated Exocytosis Vesicle Localization Secretion By Cell Presynapse Organization Axon Modulation Of Chemical Synaptic Transmission Secretion Regulation Of Exocytosis Regulation Of Vesicle-mediated Transport Exocytosis Organelle Glutamatergic Synapse Regulation Of Secretion By Cell Vesicle Docking Involved In Exocytosis Regulation Of Secretion Insulin Secretion Postsynaptic Density Regulation Of Synaptic Vesicle Exocytosis Mesonephric Duct Formation Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Mesonephric Nephron Morphogenesis Ureteric Bud Elongation Pronephric Nephron Tubule Development Mesenchymal Cell Apoptotic Process Involved In Metanephros Development Ovarian Follicle Rupture Structural Constituent Of Presynapse Vesicle Docking Epididymosome Protein Localization To Synapse Peptide Hormone Secretion Peptide Secretion Organelle Localization By Membrane Tethering	Regulation Of Establishment Of Protein Localization To Chromosome Monoubiquitinated Protein Deubiquitination Regulation Of Establishment Of Protein Localization To Telomere DNA Alkylation Repair Symbiont-mediated Disruption Of Host Cell PML Body Regulation Of Retrograde Transport, Endosome To Golgi Transcription-coupled Nucleotide-excision Repair Structural Constituent Of Presynaptic Active Zone Maintenance Of Presynaptic Active Zone Structure Presynaptic Active Zone Organization Presynaptic Active Zone Cytoplasmic Component Regulation Of Calcium-dependent Activation Of Synaptic Vesicle Fusion Golgi Ribbon Formation Negative Regulation Of Dendrite Morphogenesis Regulation Of Cellular Component Organization Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Regulation Of Telomere Capping Regulation Of Vesicle-mediated Transport Regulation Of Presynaptic Cytosolic Calcium Ion Concentration Synaptic Vesicle Priming K48-linked Deubiquitinase Activity Negative Regulation Of Gluconeogenesis Regulation Of Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Deubiquitinase Activity Maintenance Of Synapse Structure
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