RIMS1 and UNC13B

Number of citations of the paper that reports this interaction (PMID 11797009)
132

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		RIMS1	UNC13B
Gene Name		regulating synaptic membrane exocytosis 1	unc-13 homolog B (C. elegans)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Plasma Membrane Cell Junction Presynaptic Membrane Presynaptic Active Zone	Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Cell Junction Neuromuscular Junction Terminal Bouton Presynaptic Active Zone
	Molecular Function	Small GTPase Regulator Activity Protein Binding Rab GTPase Binding Ion Channel Binding Poly(A) RNA Binding Metal Ion Binding	Signal Transducer Activity Receptor Activity Protein Binding Diacylglycerol Binding Metal Ion Binding
	Biological Process	Protein Complex Assembly Intracellular Protein Transport Synaptic Transmission Neurotransmitter Secretion Visual Perception Positive Regulation Of Gene Expression Glutamate Secretion Synaptic Vesicle Exocytosis Calcium Ion-dependent Exocytosis Regulated Secretory Pathway Secretion Regulation Of Neurotransmitter Secretion Regulation Of Long-term Neuronal Synaptic Plasticity Calcium Ion-dependent Exocytosis Of Neurotransmitter Regulation Of Catalytic Activity Response To Stimulus Membrane Fusion Positive Regulation Of Inhibitory Postsynaptic Membrane Potential Positive Regulation Of Excitatory Postsynaptic Membrane Potential	Apoptotic Process Signal Transduction Synaptic Transmission Neurotransmitter Secretion Neuromuscular Junction Development Excretion Positive Regulation Of Synaptic Vesicle Priming Glutamate Secretion Synaptic Vesicle Docking Synaptic Vesicle Priming Synaptic Transmission, Glutamatergic Intracellular Signal Transduction Regulation Of Short-term Neuronal Synaptic Plasticity Innervation Positive Regulation Of Inhibitory Postsynaptic Membrane Potential
Pathways		Dopamine Neurotransmitter Release Cycle Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle Serotonin Neurotransmitter Release Cycle GABA synthesis, release, reuptake and degradation Glutamate Neurotransmitter Release Cycle Transmission across Chemical Synapses	Dopamine Neurotransmitter Release Cycle Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle Serotonin Neurotransmitter Release Cycle Glutamate Neurotransmitter Release Cycle Transmission across Chemical Synapses
Drugs
Diseases
GWAS		Cognitive performance ( 20125193)	Parkinson's disease ( 21812969)
Protein-Protein Interactions		15 interactors: CACNA1B CACNA1C CAMK2A ERC1 ERC2 RAB10 RAB26 RAB27A RAB37 RAB3A SNAP25 STX1A SYT1 UNC13B YWHAH	9 interactors: DOC2A DOC2B RIMS1 RPH3AL SPTBN2 STX1A STX1B STX2 TOE1
Entrez ID		22999	10497
HPRD ID		09435	05785
Ensembl ID		ENSG00000079841	ENSG00000198722
Uniprot IDs		B7Z7W2 B7Z9Z3 Q3ZCW0 Q86UR5	B1AM27 F8W8M9 O14795 Q4LE73
PDB IDs		2CSS
Enriched GO Terms of Interacting Partners?		Vesicle Docking Membrane Docking Vesicle Docking Involved In Exocytosis Secretion By Cell Exocytosis Establishment Of Localization In Cell Secretion Regulation Of Secretion Regulation Of Cellular Localization Regulation Of Exocytosis Cellular Localization Glutamate Secretion Synaptic Transmission Regulation Of Vesicle-mediated Transport Vesicle-mediated Transport Neurotransmitter Secretion Synaptic Vesicle Transport Protein Secretion Synaptic Vesicle Exocytosis Regulation Of Neurotransmitter Levels Positive Regulation Of Exocytosis Rab Protein Signal Transduction Regulation Of Synaptic Transmission Acid Secretion Neurotransmitter Transport Cell-cell Signaling Transport Establishment Of Vesicle Localization Dicarboxylic Acid Transport Intracellular Transport Vesicle Localization Signaling Cell Communication Synaptic Vesicle Docking Protein Transport Establishment Of Organelle Localization Establishment Of Protein Localization Amino Acid Transport Regulation Of Synaptic Plasticity Regulation Of Neurotransmitter Secretion Organelle Localization Positive Regulation Of Transport Ras Protein Signal Transduction Intracellular Signal Transduction Protein Localization Membrane Organization Intracellular Protein Transport Regulation Of Membrane Potential Positive Regulation Of Synaptic Transmission Membrane Depolarization	Neurotransmitter Secretion Regulation Of Neurotransmitter Levels Synaptic Vesicle Exocytosis Neurotransmitter Transport Secretion By Cell Secretion Synaptic Vesicle Transport Exocytosis Regulation Of Exocytosis Establishment Of Vesicle Localization Vesicle Localization Synaptic Vesicle Fusion To Presynaptic Membrane Regulation Of Secretion Vesicle-mediated Transport Establishment Of Organelle Localization Regulation Of Vesicle-mediated Transport Membrane Fusion Cell-cell Signaling Organelle Localization Positive Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Cellular Localization Establishment Of Localization In Cell Positive Regulation Of Membrane Potential Calcium Ion-dependent Exocytosis Regulation Of Calcium Ion-dependent Exocytosis Synaptic Transmission Vesicle Fusion Cellular Localization Regulation Of Neurotransmitter Secretion Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Postsynaptic Membrane Potential Organelle Fusion Positive Regulation Of Secretion Vesicle Docking Regulation Of Synaptic Vesicle Priming Synaptic Vesicle Docking Calcium Ion-dependent Exocytosis Of Neurotransmitter Membrane Docking Transport Intracellular Protein Transport Membrane Depolarization Protein Localization Positive Regulation Of Neurotransmitter Secretion Glutamate Secretion Cellular Protein Localization Protein Transport Vesicle Organization Establishment Of Protein Localization Intracellular Transport Regulation Of Synaptic Vesicle Exocytosis
Tagcloud ?		abi3bp angioedema arachidonic associations aua bicc1 chinese clusters col24a1 entity fbxl7 galnac genome han hlf hypersensitivity intolerance nsaid nsaids rad51l rad51l1 reached scan spanish suffering suggestive t13 unrelated urticaria	accn1 ago arises cgg description disturbed eef1a2 fmr1 fmrp fragile gabrd hes1 inherited intelligence interactive lending lymphoblastoid lymphoblasts males microarrays morphogenesis neurodevelopment overrepresentation ppp1r9b retardation syndrome transcriptome trinucleotide untranslated
Tagcloud (Difference) ?		abi3bp angioedema arachidonic associations aua bicc1 chinese clusters col24a1 entity fbxl7 galnac genome han hlf hypersensitivity intolerance nsaid nsaids rad51l rad51l1 reached scan spanish suffering suggestive t13 unrelated urticaria	accn1 ago arises cgg description disturbed eef1a2 fmr1 fmrp fragile gabrd hes1 inherited intelligence interactive lending lymphoblastoid lymphoblasts males microarrays morphogenesis neurodevelopment overrepresentation ppp1r9b retardation syndrome transcriptome trinucleotide untranslated
Tagcloud (Intersection) ?