RIMS1 and CACNA1C

Number of citations of the paper that reports this interaction (PMID 11438519)
11

Data Source:
HPRD (in vitro)

		RIMS1	CACNA1C
Gene Name		regulating synaptic membrane exocytosis 1	calcium channel, voltage-dependent, L type, alpha 1C subunit
Image
Gene Ontology Annotations	Cellular Component	Cytosol Plasma Membrane Cell Junction Presynaptic Membrane Presynaptic Active Zone	Caveolar Macromolecular Signaling Complex Cytoplasm Plasma Membrane Voltage-gated Calcium Channel Complex Postsynaptic Density Integral Component Of Membrane Z Disc Neuronal Cell Body Dendritic Shaft
	Molecular Function	Small GTPase Regulator Activity Protein Binding Rab GTPase Binding Ion Channel Binding Poly(A) RNA Binding Metal Ion Binding	Voltage-gated Calcium Channel Activity Protein Binding Calmodulin Binding High Voltage-gated Calcium Channel Activity Enzyme Binding Metal Ion Binding Alpha-actinin Binding
	Biological Process	Protein Complex Assembly Intracellular Protein Transport Synaptic Transmission Neurotransmitter Secretion Visual Perception Positive Regulation Of Gene Expression Glutamate Secretion Synaptic Vesicle Exocytosis Calcium Ion-dependent Exocytosis Regulated Secretory Pathway Secretion Regulation Of Neurotransmitter Secretion Regulation Of Long-term Neuronal Synaptic Plasticity Calcium Ion-dependent Exocytosis Of Neurotransmitter Regulation Of Catalytic Activity Response To Stimulus Membrane Fusion Positive Regulation Of Inhibitory Postsynaptic Membrane Potential Positive Regulation Of Excitatory Postsynaptic Membrane Potential	Energy Reserve Metabolic Process Positive Regulation Of Cytosolic Calcium Ion Concentration Synaptic Transmission Axon Guidance Adult Walking Behavior Regulation Of Blood Pressure Visual Learning Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Calcium Ion-dependent Exocytosis Regulation Of Vasoconstriction Insulin Secretion Growth Hormone Secretion Regulation Of Ion Transmembrane Transport Calcium-mediated Signaling Using Extracellular Calcium Source Glucose Homeostasis Small Molecule Metabolic Process Regulation Of Organ Growth Regulation Of Insulin Secretion Smooth Muscle Contraction Involved In Micturition Calcium Ion Transport Into Cytosol Calcium Ion Import Calcium Ion Transmembrane Transport Membrane Depolarization During Action Potential Cell Communication By Electrical Coupling Involved In Cardiac Conduction
Pathways		Dopamine Neurotransmitter Release Cycle Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle Serotonin Neurotransmitter Release Cycle GABA synthesis, release, reuptake and degradation Glutamate Neurotransmitter Release Cycle Transmission across Chemical Synapses	NCAM1 interactions Axon guidance Integration of energy metabolism Regulation of insulin secretion NCAM signaling for neurite out-growth Adrenaline,noradrenaline inhibits insulin secretion
Drugs			Isradipine Ibutilide Amlodipine Nimodipine Nisoldipine Cinnarizine Nicardipine Magnesium Sulfate Verapamil Felodipine Nitrendipine Nifedipine Calcium Mibefradil Dronedarone Clevidipine Nilvadipine Drotaverine
Diseases
GWAS		Cognitive performance ( 20125193)	Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Bipolar disorder ( 18711365) Bipolar disorder and major depressive disorder (combined) ( 20351715) Red blood cell traits ( 23222517) Schizophrenia ( 21926974 22688191) Sleep quality ( 23728906) Warfarin maintenance dose ( 18535201)
Protein-Protein Interactions		15 interactors: CACNA1B CACNA1C CAMK2A ERC1 ERC2 RAB10 RAB26 RAB27A RAB37 RAB3A SNAP25 STX1A SYT1 UNC13B YWHAH	11 interactors: CABP1 CACNB3 COPS5 GNB1 HDAC4 PCBD1 PPM1A PRKACA RIMS1 RYR2 SRI
Entrez ID		22999	775
HPRD ID		09435	00246
Ensembl ID		ENSG00000079841
Uniprot IDs		B7Z7W2 B7Z9Z3 Q3ZCW0 Q86UR5	Q13936
PDB IDs		2CSS	1T0J 2BE6 2F3Y 2F3Z 2LQC 3G43 3OXQ
Enriched GO Terms of Interacting Partners?		Vesicle Docking Membrane Docking Vesicle Docking Involved In Exocytosis Secretion By Cell Exocytosis Establishment Of Localization In Cell Secretion Regulation Of Secretion Regulation Of Cellular Localization Regulation Of Exocytosis Cellular Localization Glutamate Secretion Synaptic Transmission Regulation Of Vesicle-mediated Transport Vesicle-mediated Transport Neurotransmitter Secretion Synaptic Vesicle Transport Protein Secretion Synaptic Vesicle Exocytosis Regulation Of Neurotransmitter Levels Positive Regulation Of Exocytosis Rab Protein Signal Transduction Regulation Of Synaptic Transmission Acid Secretion Neurotransmitter Transport Cell-cell Signaling Transport Establishment Of Vesicle Localization Dicarboxylic Acid Transport Intracellular Transport Vesicle Localization Signaling Cell Communication Synaptic Vesicle Docking Protein Transport Establishment Of Organelle Localization Establishment Of Protein Localization Amino Acid Transport Regulation Of Synaptic Plasticity Regulation Of Neurotransmitter Secretion Organelle Localization Positive Regulation Of Transport Ras Protein Signal Transduction Intracellular Signal Transduction Protein Localization Membrane Organization Intracellular Protein Transport Regulation Of Membrane Potential Positive Regulation Of Synaptic Transmission Membrane Depolarization	Regulation Of Calcium Ion Transmembrane Transport Regulation Of Calcium Ion Transmembrane Transporter Activity Regulation Of Cation Channel Activity Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Regulation Of Calcium Ion Transport Regulation Of Cardiac Muscle Contraction Regulation Of Striated Muscle Contraction Regulation Of Voltage-gated Calcium Channel Activity Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Cellular Response To Catecholamine Stimulus Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Muscle Contraction Regulation Of Ion Transmembrane Transport Regulation Of Heart Contraction Regulation Of Intracellular Transport Regulation Of Nucleocytoplasmic Transport Regulation Of Cellular Localization Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Negative Regulation Of Protein Import Into Nucleus Regulation Of Binding Regulation Of Intracellular Protein Transport Regulation Of Ion Transport Regulation Of Heart Rate Regulation Of Membrane Potential Regulation Of Calcium Ion Transport Into Cytosol Negative Regulation Of Protein Localization To Nucleus Negative Regulation Of Intracellular Protein Transport Calcium-mediated Signaling Cell Communication By Electrical Coupling Involved In Cardiac Conduction Calcium-mediated Signaling Using Intracellular Calcium Source Regulation Of Cell Communication By Electrical Coupling Cell Communication By Electrical Coupling Negative Regulation Of Intracellular Transport Negative Regulation Of Transport Cellular Metal Ion Homeostasis Cellular Response To Epinephrine Stimulus Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Negative Regulation Of Calcium Ion Transmembrane Transporter Activity Cell-cell Signaling Response To Epinephrine Second-messenger-mediated Signaling Cellular Cation Homeostasis Regulation Of Protein Binding Negative Regulation Of Cation Channel Activity Cellular Ion Homeostasis Metal Ion Homeostasis Cellular Response To Organonitrogen Compound Regulation Of Ion Homeostasis
Tagcloud ?		abi3bp angioedema arachidonic associations aua bicc1 chinese clusters col24a1 entity fbxl7 galnac genome han hlf hypersensitivity intolerance nsaid nsaids rad51l rad51l1 reached scan spanish suffering suggestive t13 unrelated urticaria	ad1 ad2 ad3 aom azoxymethane bcorl1 c57bl carcinogenesis colitis colon dextran dss dysplasia foxo3 gradually irrelevant itk kcna1 microarray mir named pictar preliminarily regular rspo2 sequentially sulfate targetscan tle4
Tagcloud (Difference) ?		abi3bp angioedema arachidonic associations aua bicc1 chinese clusters col24a1 entity fbxl7 galnac genome han hlf hypersensitivity intolerance nsaid nsaids rad51l rad51l1 reached scan spanish suffering suggestive t13 unrelated urticaria	ad1 ad2 ad3 aom azoxymethane bcorl1 c57bl carcinogenesis colitis colon dextran dss dysplasia foxo3 gradually irrelevant itk kcna1 microarray mir named pictar preliminarily regular rspo2 sequentially sulfate targetscan tle4
Tagcloud (Intersection) ?