RIMS1 and CACNA1B

Number of citations of the paper that reports this interaction (PMID 11438518)
42

Data Source:
HPRD (in vitro)

		RIMS1	CACNA1B
Gene Name		regulating synaptic membrane exocytosis 1	calcium channel, voltage-dependent, N type, alpha 1B subunit
Image
Gene Ontology Annotations	Cellular Component	Cytosol Plasma Membrane Cell Junction Presynaptic Membrane Presynaptic Active Zone	Plasma Membrane Voltage-gated Calcium Channel Complex Dendrite Neuronal Cell Body
	Molecular Function	Small GTPase Regulator Activity Protein Binding Rab GTPase Binding Ion Channel Binding Poly(A) RNA Binding Metal Ion Binding	Voltage-gated Calcium Channel Activity Calcium Ion Binding Protein Binding ATP Binding Protein C-terminus Binding High Voltage-gated Calcium Channel Activity
	Biological Process	Protein Complex Assembly Intracellular Protein Transport Synaptic Transmission Neurotransmitter Secretion Visual Perception Positive Regulation Of Gene Expression Glutamate Secretion Synaptic Vesicle Exocytosis Calcium Ion-dependent Exocytosis Regulated Secretory Pathway Secretion Regulation Of Neurotransmitter Secretion Regulation Of Long-term Neuronal Synaptic Plasticity Calcium Ion-dependent Exocytosis Of Neurotransmitter Regulation Of Catalytic Activity Response To Stimulus Membrane Fusion Positive Regulation Of Inhibitory Postsynaptic Membrane Potential Positive Regulation Of Excitatory Postsynaptic Membrane Potential	Transport Synaptic Transmission Neurotransmitter Secretion Locomotory Behavior Regulation Of Heart Contraction Regulation Of Blood Pressure Regulation Of Ion Transmembrane Transport Response To Pain Membrane Depolarization Regulation Of Calcium Ion Transport Calcium Ion Import Calcium Ion Transmembrane Transport Membrane Depolarization During Action Potential
Pathways		Dopamine Neurotransmitter Release Cycle Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle Serotonin Neurotransmitter Release Cycle GABA synthesis, release, reuptake and degradation Glutamate Neurotransmitter Release Cycle Transmission across Chemical Synapses	Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels Transmission across Chemical Synapses
Drugs
Diseases
GWAS		Cognitive performance ( 20125193)
Protein-Protein Interactions		15 interactors: CACNA1B CACNA1C CAMK2A ERC1 ERC2 RAB10 RAB26 RAB27A RAB37 RAB3A SNAP25 STX1A SYT1 UNC13B YWHAH	9 interactors: APBA1 CACNB3 GNAO1 GNB1 PDLIM5 PPM1A RGS12 RIMS1 RXRB
Entrez ID		22999	774
HPRD ID		09435	03005
Ensembl ID		ENSG00000079841	ENSG00000148408
Uniprot IDs		B7Z7W2 B7Z9Z3 Q3ZCW0 Q86UR5	B1AQK4 B1AQK7 Q00975
PDB IDs		2CSS	2LCM
Enriched GO Terms of Interacting Partners?		Vesicle Docking Membrane Docking Vesicle Docking Involved In Exocytosis Secretion By Cell Exocytosis Establishment Of Localization In Cell Secretion Regulation Of Secretion Regulation Of Cellular Localization Regulation Of Exocytosis Cellular Localization Glutamate Secretion Synaptic Transmission Regulation Of Vesicle-mediated Transport Vesicle-mediated Transport Neurotransmitter Secretion Synaptic Vesicle Transport Protein Secretion Synaptic Vesicle Exocytosis Regulation Of Neurotransmitter Levels Positive Regulation Of Exocytosis Rab Protein Signal Transduction Regulation Of Synaptic Transmission Acid Secretion Neurotransmitter Transport Cell-cell Signaling Transport Establishment Of Vesicle Localization Dicarboxylic Acid Transport Intracellular Transport Vesicle Localization Signaling Cell Communication Synaptic Vesicle Docking Protein Transport Establishment Of Organelle Localization Establishment Of Protein Localization Amino Acid Transport Regulation Of Synaptic Plasticity Regulation Of Neurotransmitter Secretion Organelle Localization Positive Regulation Of Transport Ras Protein Signal Transduction Intracellular Signal Transduction Protein Localization Membrane Organization Intracellular Protein Transport Regulation Of Membrane Potential Positive Regulation Of Synaptic Transmission Membrane Depolarization	Glutamate Secretion Synaptic Transmission Dopamine Receptor Signaling Pathway Signaling Cell Communication Acid Secretion Cell-cell Signaling Dicarboxylic Acid Transport Membrane Depolarization Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Cellular Response To Hormone Stimulus G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Gamma-aminobutyric Acid Secretion System Development Amino Acid Transport Transcription Initiation From RNA Polymerase II Promoter Negative Regulation Of SMAD Protein Complex Assembly Positive Regulation Of Inhibitory Postsynaptic Membrane Potential Cellular Response To Acid Chemical Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of Calcium Ion Transport Cardiac Muscle Cell Apoptotic Process Muscle Cell Apoptotic Process Response To Organonitrogen Compound Multicellular Organismal Development DNA-templated Transcription, Initiation Calcium Ion-dependent Exocytosis Of Neurotransmitter N-terminal Protein Myristoylation Locomotory Behavior Gamma-aminobutyric Acid Transport Protein Myristoylation Anatomical Structure Development Response To Organic Cyclic Compound Response To Hormone Regulation Of Membrane Potential Positive Regulation Of Metabolic Process Peptidyl-threonine Dephosphorylation Signal Transduction Cellular Response To Prostaglandin E Stimulus Regulation Of Inhibitory Postsynaptic Membrane Potential G-protein Coupled Acetylcholine Receptor Signaling Pathway Carboxylic Acid Transport Organic Acid Transport Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Developmental Process Negative Regulation Of NF-kappaB Import Into Nucleus Nervous System Development Cellular Response To Prostaglandin Stimulus
Tagcloud ?		abi3bp angioedema arachidonic associations aua bicc1 chinese clusters col24a1 entity fbxl7 galnac genome han hlf hypersensitivity intolerance nsaid nsaids rad51l rad51l1 reached scan spanish suffering suggestive t13 unrelated urticaria	annealed arguably asd autism bd bipolar candidates chip cnvs disparate fgfr1 glycogen gsk3beta gwass incorporated investigators lithium microarrays nrng pathophysiology pcdh9 phosphoinositide revolving salts searches seemingly shortcomings snap29 sz
Tagcloud (Difference) ?		abi3bp angioedema arachidonic associations aua bicc1 chinese clusters col24a1 entity fbxl7 galnac genome han hlf hypersensitivity intolerance nsaid nsaids rad51l rad51l1 reached scan spanish suffering suggestive t13 unrelated urticaria	annealed arguably asd autism bd bipolar candidates chip cnvs disparate fgfr1 glycogen gsk3beta gwass incorporated investigators lithium microarrays nrng pathophysiology pcdh9 phosphoinositide revolving salts searches seemingly shortcomings snap29 sz
Tagcloud (Intersection) ?