RIMS1 and RAB37

Number of citations of the paper that reports this interaction (PMID 12578829)
33

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro)

		RIMS1	RAB37
Gene Name		regulating synaptic membrane exocytosis 1	RAB37, member RAS oncogene family
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Plasma Membrane Cell Junction Presynaptic Membrane Presynaptic Active Zone	Endosome Endoplasmic Reticulum-Golgi Intermediate Compartment Plasma Membrane Secretory Granule Membrane
	Molecular Function	Small GTPase Regulator Activity Protein Binding Rab GTPase Binding Ion Channel Binding Poly(A) RNA Binding Metal Ion Binding	GTPase Activity GTP Binding GDP Binding
	Biological Process	Protein Complex Assembly Intracellular Protein Transport Synaptic Transmission Neurotransmitter Secretion Visual Perception Positive Regulation Of Gene Expression Glutamate Secretion Synaptic Vesicle Exocytosis Calcium Ion-dependent Exocytosis Regulated Secretory Pathway Secretion Regulation Of Neurotransmitter Secretion Regulation Of Long-term Neuronal Synaptic Plasticity Calcium Ion-dependent Exocytosis Of Neurotransmitter Regulation Of Catalytic Activity Response To Stimulus Membrane Fusion Positive Regulation Of Inhibitory Postsynaptic Membrane Potential Positive Regulation Of Excitatory Postsynaptic Membrane Potential	Intracellular Protein Transport Vesicle Docking Involved In Exocytosis Protein Secretion Regulation Of Exocytosis Rab Protein Signal Transduction Protein Localization To Plasma Membrane
Pathways		Dopamine Neurotransmitter Release Cycle Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle Serotonin Neurotransmitter Release Cycle GABA synthesis, release, reuptake and degradation Glutamate Neurotransmitter Release Cycle Transmission across Chemical Synapses
Drugs
Diseases
GWAS		Cognitive performance ( 20125193)
Protein-Protein Interactions		15 interactors: CACNA1B CACNA1C CAMK2A ERC1 ERC2 RAB10 RAB26 RAB27A RAB37 RAB3A SNAP25 STX1A SYT1 UNC13B YWHAH	5 interactors: EWSR1 MAL2 RAB5A RABGGTB RIMS1
Entrez ID		22999	326624
HPRD ID		09435	06702
Ensembl ID		ENSG00000079841	ENSG00000172794
Uniprot IDs		B7Z7W2 B7Z9Z3 Q3ZCW0 Q86UR5	B7Z3L0 Q96AX2
PDB IDs		2CSS
Enriched GO Terms of Interacting Partners?		Vesicle Docking Membrane Docking Vesicle Docking Involved In Exocytosis Secretion By Cell Exocytosis Establishment Of Localization In Cell Secretion Regulation Of Secretion Regulation Of Cellular Localization Regulation Of Exocytosis Cellular Localization Glutamate Secretion Synaptic Transmission Regulation Of Vesicle-mediated Transport Vesicle-mediated Transport Neurotransmitter Secretion Synaptic Vesicle Transport Protein Secretion Synaptic Vesicle Exocytosis Regulation Of Neurotransmitter Levels Positive Regulation Of Exocytosis Rab Protein Signal Transduction Regulation Of Synaptic Transmission Acid Secretion Neurotransmitter Transport Cell-cell Signaling Transport Establishment Of Vesicle Localization Dicarboxylic Acid Transport Intracellular Transport Vesicle Localization Signaling Cell Communication Synaptic Vesicle Docking Protein Transport Establishment Of Organelle Localization Establishment Of Protein Localization Amino Acid Transport Regulation Of Synaptic Plasticity Regulation Of Neurotransmitter Secretion Organelle Localization Positive Regulation Of Transport Ras Protein Signal Transduction Intracellular Signal Transduction Protein Localization Membrane Organization Intracellular Protein Transport Regulation Of Membrane Potential Positive Regulation Of Synaptic Transmission Membrane Depolarization	Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Neuronal Synaptic Plasticity Regulation Of Neurotransmitter Secretion Synaptic Vesicle Transport Regulation Of Synaptic Plasticity Visual Perception Sensory Perception Of Light Stimulus Establishment Of Vesicle Localization Vesicle Localization Regulation Of Endosome Size Receptor Internalization Involved In Canonical Wnt Signaling Pathway Positive Regulation Of Inhibitory Postsynaptic Membrane Potential Regulation Of Synaptic Transmission Protein Geranylgeranylation Establishment Of Organelle Localization Calcium Ion-dependent Exocytosis Of Neurotransmitter Organelle Localization Regulation Of Inhibitory Postsynaptic Membrane Potential Protein Prenylation Early Endosome To Late Endosome Transport Synaptic Transmission Glutamate Secretion Regulation Of Secretion Positive Regulation Of Smooth Muscle Cell Migration Positive Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Synaptic Vesicle Exocytosis Membrane Hyperpolarization Synaptic Vesicle Recycling Sensory Perception Regulation Of Synaptic Vesicle Transport Positive Regulation Of Membrane Potential Regulation Of Smooth Muscle Cell Migration Receptor Internalization Calcium Ion-dependent Exocytosis Regulation Of Filopodium Assembly Cell-cell Signaling Intracellular Protein Transport Regulated Secretory Pathway Synaptic Vesicle Exocytosis Positive Regulation Of Smooth Muscle Cell Proliferation Rab Protein Signal Transduction Acid Secretion Positive Regulation Of Exocytosis Regulation Of Cellular Localization Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Postsynaptic Membrane Potential Neurological System Process Receptor Metabolic Process Dicarboxylic Acid Transport Canonical Wnt Signaling Pathway
Tagcloud ?		abi3bp angioedema arachidonic associations aua bicc1 chinese clusters col24a1 entity fbxl7 galnac genome han hlf hypersensitivity intolerance nsaid nsaids rad51l rad51l1 reached scan spanish suffering suggestive t13 unrelated urticaria	colocalized constitutively controlling elucidated gtpase healing immunocytochemical interacting interacts isoforms knockdown lc macrophages munc13 positively rab27b rab30 rab33a rab3b rab40c raw264 secretion sirna skin tnf upregulated vesicles wound
Tagcloud (Difference) ?		abi3bp angioedema arachidonic associations aua bicc1 chinese clusters col24a1 entity fbxl7 galnac genome han hlf hypersensitivity intolerance nsaid nsaids rad51l rad51l1 reached scan spanish suffering suggestive t13 unrelated urticaria	colocalized constitutively controlling elucidated gtpase healing immunocytochemical interacting interacts isoforms knockdown lc macrophages munc13 positively rab27b rab30 rab33a rab3b rab40c raw264 secretion sirna skin tnf upregulated vesicles wound
Tagcloud (Intersection) ?