RIMS1 and ERC1

Number of citations of the paper that reports this interaction (PMID 12391317)
37

Data Source:
HPRD (in vitro, two hybrid)

		RIMS1	ERC1
Gene Name		regulating synaptic membrane exocytosis 1	ELKS/RAB6-interacting/CAST family member 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Plasma Membrane Cell Junction Presynaptic Membrane Presynaptic Active Zone	Golgi Membrane Cytoplasm IkappaB Kinase Complex Presynaptic Membrane Synapse
	Molecular Function	Small GTPase Regulator Activity Protein Binding Rab GTPase Binding Ion Channel Binding Poly(A) RNA Binding Metal Ion Binding	Protein Binding Rab GTPase Binding PDZ Domain Binding Leucine Zipper Domain Binding
	Biological Process	Protein Complex Assembly Intracellular Protein Transport Synaptic Transmission Neurotransmitter Secretion Visual Perception Positive Regulation Of Gene Expression Glutamate Secretion Synaptic Vesicle Exocytosis Calcium Ion-dependent Exocytosis Regulated Secretory Pathway Secretion Regulation Of Neurotransmitter Secretion Regulation Of Long-term Neuronal Synaptic Plasticity Calcium Ion-dependent Exocytosis Of Neurotransmitter Regulation Of Catalytic Activity Response To Stimulus Membrane Fusion Positive Regulation Of Inhibitory Postsynaptic Membrane Potential Positive Regulation Of Excitatory Postsynaptic Membrane Potential	Regulation Of Transcription, DNA-templated I-kappaB Phosphorylation Multicellular Organismal Development Protein Transport Retrograde Transport, Endosome To Golgi Positive Regulation Of NF-kappaB Transcription Factor Activity
Pathways		Dopamine Neurotransmitter Release Cycle Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle Serotonin Neurotransmitter Release Cycle GABA synthesis, release, reuptake and degradation Glutamate Neurotransmitter Release Cycle Transmission across Chemical Synapses
Drugs
Diseases
GWAS		Cognitive performance ( 20125193)	Bone mineral density ( 22504420)
Protein-Protein Interactions		15 interactors: CACNA1B CACNA1C CAMK2A ERC1 ERC2 RAB10 RAB26 RAB27A RAB37 RAB3A SNAP25 STX1A SYT1 UNC13B YWHAH	7 interactors: APP ITSN2 PPFIA1 RAB6A RAB6B RIMS1 YWHAG
Entrez ID		22999	23085
HPRD ID		09435	06181
Ensembl ID		ENSG00000079841	ENSG00000082805
Uniprot IDs		B7Z7W2 B7Z9Z3 Q3ZCW0 Q86UR5	Q8IUD2
PDB IDs		2CSS
Enriched GO Terms of Interacting Partners?		Vesicle Docking Membrane Docking Vesicle Docking Involved In Exocytosis Secretion By Cell Exocytosis Establishment Of Localization In Cell Secretion Regulation Of Secretion Regulation Of Cellular Localization Regulation Of Exocytosis Cellular Localization Glutamate Secretion Synaptic Transmission Regulation Of Vesicle-mediated Transport Vesicle-mediated Transport Neurotransmitter Secretion Synaptic Vesicle Transport Protein Secretion Synaptic Vesicle Exocytosis Regulation Of Neurotransmitter Levels Positive Regulation Of Exocytosis Rab Protein Signal Transduction Regulation Of Synaptic Transmission Acid Secretion Neurotransmitter Transport Cell-cell Signaling Transport Establishment Of Vesicle Localization Dicarboxylic Acid Transport Intracellular Transport Vesicle Localization Signaling Cell Communication Synaptic Vesicle Docking Protein Transport Establishment Of Organelle Localization Establishment Of Protein Localization Amino Acid Transport Regulation Of Synaptic Plasticity Regulation Of Neurotransmitter Secretion Organelle Localization Positive Regulation Of Transport Ras Protein Signal Transduction Intracellular Signal Transduction Protein Localization Membrane Organization Intracellular Protein Transport Regulation Of Membrane Potential Positive Regulation Of Synaptic Transmission Membrane Depolarization	Establishment Of Localization In Cell Cellular Localization Vesicle-mediated Transport Transport Glutamate Secretion Intracellular Transport Retrograde Vesicle-mediated Transport, Golgi To ER Intracellular Protein Transport Intra-Golgi Vesicle-mediated Transport Rab Protein Signal Transduction Acid Secretion Retrograde Transport, Endosome To Golgi Dicarboxylic Acid Transport Secretion By Cell Cellular Protein Localization Protein Transport Neurotransmitter Secretion Establishment Of Protein Localization Synaptic Growth At Neuromuscular Junction Secretion Microtubule-based Transport Cytoskeleton-dependent Intracellular Transport Regulation Of Neurotransmitter Levels Collateral Sprouting In Absence Of Injury Minus-end-directed Organelle Transport Along Microtubule Peptidyl-cysteine Methylation Amino Acid Transport Signaling Regulation Of Synaptic Plasticity Neurotransmitter Transport Cell Communication Protein Localization Collateral Sprouting Axon Midline Choice Point Recognition Positive Regulation Of Inhibitory Postsynaptic Membrane Potential Endosomal Transport Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Ras Protein Signal Transduction Axon Choice Point Recognition Calcium Ion-dependent Exocytosis Of Neurotransmitter Regulation Of Cellular Localization Golgi Vesicle Transport Negative Regulation Of Stress Fiber Assembly Neuron Remodeling Regulation Of Catalytic Activity Early Endosome To Golgi Transport Carboxylic Acid Transport Regulation Of Synaptic Transmission Organic Acid Transport Negative Regulation Of Actin Filament Bundle Assembly
Tagcloud ?		abi3bp angioedema arachidonic associations aua bicc1 chinese clusters col24a1 entity fbxl7 galnac genome han hlf hypersensitivity intolerance nsaid nsaids rad51l rad51l1 reached scan spanish suffering suggestive t13 unrelated urticaria	betweenness calr calreticulin centrosome chance coagulation colocalized create cytoskeleton ddx3x dengue denv dsrna golga2 interacted mosquito ns3 ns5 occupy overlapping preferentially replication replicon starting throughput transmitted trip11 ube2i vast
Tagcloud (Difference) ?		abi3bp angioedema arachidonic associations aua bicc1 chinese clusters col24a1 entity fbxl7 galnac genome han hlf hypersensitivity intolerance nsaid nsaids rad51l rad51l1 reached scan spanish suffering suggestive t13 unrelated urticaria	betweenness calr calreticulin centrosome chance coagulation colocalized create cytoskeleton ddx3x dengue denv dsrna golga2 interacted mosquito ns3 ns5 occupy overlapping preferentially replication replicon starting throughput transmitted trip11 ube2i vast
Tagcloud (Intersection) ?