ERC2

Description		ELKS/RAB6-interacting/CAST family member 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Growth Cone Presynaptic Membrane Cell Projection Synapse Presynaptic Active Zone Presynapse Presynaptic Active Zone Cytoplasmic Component Glutamatergic Synapse GABA-ergic Synapse
	Molecular Function	Protein Binding Structural Constituent Of Presynaptic Active Zone
	Biological Process	Synaptic Vesicle Priming Maintenance Of Presynaptic Active Zone Structure Regulation Of Presynaptic Cytosolic Calcium Ion Concentration Regulation Of Calcium-dependent Activation Of Synaptic Vesicle Fusion
Pathways
Drugs
Diseases
GWAS		Acute lymphoblastic leukemia (childhood) ( 22076464) Adult body size ( 32376654) Alcohol dependence ( 24166409) Bipolar disorder and schizophrenia ( 21057379) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Chronotype ( 26955885) Cortical surface area (MOSTest) ( 32665545) Daytime sleep phenotypes ( 27126917) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Heel bone mineral density ( 30598549 28869591) Hip bone size ( 31053729) Hip circumference adjusted for BMI ( 34021172) Hip geometry ( 17903296) Intertrochanteric region size ( 31053729) Lateral thalamic nuclei volume ( 34006833) Lung function in never smokers (high FEV1 vs average FEV1) ( 26423011) Morning vs. evening chronotype ( 26955885 27494321) Night sleep phenotypes ( 27126917) Periodontitis (Mean PAL) ( 24024966) Post bronchodilator FEV1/FVC ratio ( 26634245) Refractive error ( 32231278) Sense of smell ( 26632684) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Tourette syndrome ( 30818990) Trochanter size ( 31053729)
Novel Interacting Genes		1 novel interacting genes: HNF1B
Interacting Genes		9 interacting genes: BSN MYB NRIP1 PCLO PPFIA1 PPFIA2 PPFIA3 PPFIA4 RIMS1
Entrez ID		26059
HPRD ID		10810
Ensembl ID		ENSG00000187672
Uniprot IDs		H7C4G9 O15083
PDB IDs
Enriched GO Terms of Interacting Partners?		Presynaptic Active Zone Synapse Organization Cell Junction Organization Maintenance Of Synapse Structure Structural Constituent Of Presynaptic Active Zone Maintenance Of Presynaptic Active Zone Structure Cell Junction Maintenance Presynaptic Active Zone Organization Cellular Component Maintenance Cytoskeleton Of Presynaptic Active Zone Synaptic Vesicle Exocytosis Presynaptic Active Zone Assembly Signal Release Organelle Localization Synapse Synaptic Vesicle Docking Presynaptic Active Zone Cytoplasmic Component Vesicle-mediated Transport In Synapse Synaptic Vesicle Clustering Regulated Exocytosis Vesicle Localization Secretion By Cell Presynapse Organization Axon Modulation Of Chemical Synaptic Transmission Secretion Regulation Of Exocytosis Regulation Of Vesicle-mediated Transport Exocytosis Organelle Glutamatergic Synapse Regulation Of Secretion By Cell Vesicle Docking Involved In Exocytosis Regulation Of Secretion Insulin Secretion Postsynaptic Density Regulation Of Synaptic Vesicle Exocytosis Mesonephric Duct Formation Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Mesonephric Nephron Morphogenesis Ureteric Bud Elongation Pronephric Nephron Tubule Development Mesenchymal Cell Apoptotic Process Involved In Metanephros Development Ovarian Follicle Rupture Structural Constituent Of Presynapse Vesicle Docking Epididymosome Protein Localization To Synapse Peptide Hormone Secretion Peptide Secretion Organelle Localization By Membrane Tethering
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