RIMS1 and RAB26

Number of citations of the paper that reports this interaction (PMID 12578829)
33

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		RIMS1	RAB26
Gene Name		regulating synaptic membrane exocytosis 1	RAB26, member RAS oncogene family
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Gene Ontology Annotations	Cellular Component	Cytosol Plasma Membrane Cell Junction Presynaptic Membrane Presynaptic Active Zone	Golgi Membrane Endosome Plasma Membrane Transport Vesicle Membrane Secretory Granule Membrane Intrinsic Component Of Plasma Membrane
	Molecular Function	Small GTPase Regulator Activity Protein Binding Rab GTPase Binding Ion Channel Binding Poly(A) RNA Binding Metal Ion Binding	GTPase Activity Protein Binding GTP Binding GMP Binding GDP Binding
	Biological Process	Protein Complex Assembly Intracellular Protein Transport Synaptic Transmission Neurotransmitter Secretion Visual Perception Positive Regulation Of Gene Expression Glutamate Secretion Synaptic Vesicle Exocytosis Calcium Ion-dependent Exocytosis Regulated Secretory Pathway Secretion Regulation Of Neurotransmitter Secretion Regulation Of Long-term Neuronal Synaptic Plasticity Calcium Ion-dependent Exocytosis Of Neurotransmitter Regulation Of Catalytic Activity Response To Stimulus Membrane Fusion Positive Regulation Of Inhibitory Postsynaptic Membrane Potential Positive Regulation Of Excitatory Postsynaptic Membrane Potential	Vesicle Docking Involved In Exocytosis Protein Secretion Regulation Of Exocytosis Rab Protein Signal Transduction Exocrine System Development Golgi To Plasma Membrane Protein Transport Regulated Secretory Pathway
Pathways		Dopamine Neurotransmitter Release Cycle Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle Serotonin Neurotransmitter Release Cycle GABA synthesis, release, reuptake and degradation Glutamate Neurotransmitter Release Cycle Transmission across Chemical Synapses
Drugs
Diseases
GWAS		Cognitive performance ( 20125193)
Protein-Protein Interactions		15 interactors: CACNA1B CACNA1C CAMK2A ERC1 ERC2 RAB10 RAB26 RAB27A RAB37 RAB3A SNAP25 STX1A SYT1 UNC13B YWHAH	3 interactors: APP GCH1 RIMS1
Entrez ID		22999	25837
HPRD ID		09435	05676
Ensembl ID		ENSG00000079841	ENSG00000167964
Uniprot IDs		B7Z7W2 B7Z9Z3 Q3ZCW0 Q86UR5	B2RAA6 Q9ULW5
PDB IDs		2CSS	2G6B
Enriched GO Terms of Interacting Partners?		Vesicle Docking Membrane Docking Vesicle Docking Involved In Exocytosis Secretion By Cell Exocytosis Establishment Of Localization In Cell Secretion Regulation Of Secretion Regulation Of Cellular Localization Regulation Of Exocytosis Cellular Localization Glutamate Secretion Synaptic Transmission Regulation Of Vesicle-mediated Transport Vesicle-mediated Transport Neurotransmitter Secretion Synaptic Vesicle Transport Protein Secretion Synaptic Vesicle Exocytosis Regulation Of Neurotransmitter Levels Positive Regulation Of Exocytosis Rab Protein Signal Transduction Regulation Of Synaptic Transmission Acid Secretion Neurotransmitter Transport Cell-cell Signaling Transport Establishment Of Vesicle Localization Dicarboxylic Acid Transport Intracellular Transport Vesicle Localization Signaling Cell Communication Synaptic Vesicle Docking Protein Transport Establishment Of Organelle Localization Establishment Of Protein Localization Amino Acid Transport Regulation Of Synaptic Plasticity Regulation Of Neurotransmitter Secretion Organelle Localization Positive Regulation Of Transport Ras Protein Signal Transduction Intracellular Signal Transduction Protein Localization Membrane Organization Intracellular Protein Transport Regulation Of Membrane Potential Positive Regulation Of Synaptic Transmission Membrane Depolarization	Neuromuscular Process Neurological System Process 7,8-dihydroneopterin 3'-triphosphate Biosynthetic Process Regulation Of Lung Blood Pressure Synaptic Growth At Neuromuscular Junction Collateral Sprouting In Absence Of Injury Dihydrobiopterin Metabolic Process Cellular Component Assembly Collateral Sprouting Axon Midline Choice Point Recognition Positive Regulation Of Inhibitory Postsynaptic Membrane Potential Exocytosis Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Calcium Ion-dependent Exocytosis Of Neurotransmitter Regulation Of Catalytic Activity Tetrahydrofolate Biosynthetic Process Neuron Remodeling Tetrahydrobiopterin Biosynthetic Process Secretion By Cell Dopamine Biosynthetic Process Regulation Of Inhibitory Postsynaptic Membrane Potential Nitric Oxide Biosynthetic Process Neuromuscular Process Controlling Posture Secretion Positive Regulation Of Nitric-oxide Synthase Activity Cellular Copper Ion Homeostasis Catecholamine Biosynthetic Process Copper Ion Homeostasis Suckling Behavior Tetrahydrofolate Metabolic Process Positive Regulation Of Monooxygenase Activity Glutamate Secretion Positive Regulation Of Metabolic Process Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Innate Immune Response Dopamine Metabolic Process Nitric Oxide Metabolic Process Neuron Maturation MRNA Polyadenylation Regulation Of Epidermal Growth Factor-activated Receptor Activity Folic Acid-containing Compound Biosynthetic Process Reactive Nitrogen Species Metabolic Process Regulation Of Long-term Neuronal Synaptic Plasticity Mating Behavior Vasodilation Positive Regulation Of Excitatory Postsynaptic Membrane Potential Endoplasmic Reticulum Calcium Ion Homeostasis Membrane Hyperpolarization RNA Polyadenylation
Tagcloud ?		abi3bp angioedema arachidonic associations aua bicc1 chinese clusters col24a1 entity fbxl7 galnac genome han hlf hypersensitivity intolerance nsaid nsaids rad51l rad51l1 reached scan spanish suffering suggestive t13 unrelated urticaria	aberrations adpkd array autosomal breakpoints cgh constitute contiguous deletions elucidation etc heterozygous immediately lies ligation mlpa monoallelic multiplex nthl1 outside pkd1 pkd2 pkdts polycystic proved tsc tsc1 tsc2 tuberous
Tagcloud (Difference) ?		abi3bp angioedema arachidonic associations aua bicc1 chinese clusters col24a1 entity fbxl7 galnac genome han hlf hypersensitivity intolerance nsaid nsaids rad51l rad51l1 reached scan spanish suffering suggestive t13 unrelated urticaria	aberrations adpkd array autosomal breakpoints cgh constitute contiguous deletions elucidation etc heterozygous immediately lies ligation mlpa monoallelic multiplex nthl1 outside pkd1 pkd2 pkdts polycystic proved tsc tsc1 tsc2 tuberous
Tagcloud (Intersection) ?