ERC2 and PPFIA4

Number of citations of the paper that reports this interaction (PMID 12923177)
33

Data Source:
BioGRID (two hybrid, pull down, two hybrid)
HPRD (two hybrid, in vitro)

		ERC2	PPFIA4
Gene Name		ELKS/RAB6-interacting/CAST family member 2	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytoskeleton Cell Junction Growth Cone Presynaptic Membrane Presynaptic Active Zone	Intracellular Cytosol Cell Surface Synapse Presynaptic Active Zone
	Molecular Function	Protein Binding	Protein Binding
	Biological Process		Synaptic Transmission Neurotransmitter Secretion Glutamate Secretion
Pathways			Dopamine Neurotransmitter Release Cycle Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle Serotonin Neurotransmitter Release Cycle Glutamate Neurotransmitter Release Cycle Transmission across Chemical Synapses
Drugs
Diseases
GWAS		Bipolar disorder and schizophrenia ( 21057379) Hip geometry ( 17903296)
Protein-Protein Interactions		8 interactors: BSN MYB PCLO PPFIA1 PPFIA2 PPFIA3 PPFIA4 RIMS1	5 interactors: AGTPBP1 CAST ERC2 GIT1 NCOA2
Entrez ID		26059	8497
HPRD ID		10810	16012
Ensembl ID		ENSG00000187672	ENSG00000143847
Uniprot IDs		O15083	B3KN22 O75335
PDB IDs
Enriched GO Terms of Interacting Partners?		Glutamate Secretion Neurotransmitter Secretion Regulation Of Neurotransmitter Levels Neurotransmitter Transport Acid Secretion Dicarboxylic Acid Transport Synaptic Transmission Amino Acid Transport Cell-cell Signaling Secretion By Cell Secretion Carboxylic Acid Transport Organic Acid Transport Organic Anion Transport Anion Transport Ion Transport Establishment Of Localization In Cell Cellular Localization Transport Synaptic Vesicle Exocytosis Regulation Of Neuronal Synaptic Plasticity Signaling Cell Communication Synaptic Vesicle Transport Regulation Of Synaptic Plasticity Cell-matrix Adhesion Positive Regulation Of Inhibitory Postsynaptic Membrane Potential Establishment Of Vesicle Localization Vesicle Localization Cell-substrate Adhesion Calcium Ion-dependent Exocytosis Of Neurotransmitter Negative Regulation Of Stress Fiber Assembly Regulation Of Cellular Localization Negative Regulation Of Actin Filament Bundle Assembly Positive Regulation Of Histone H3-K9 Methylation Regulation Of Short-term Neuronal Synaptic Plasticity Regulation Of Synaptic Transmission Regulation Of Inhibitory Postsynaptic Membrane Potential Negative Regulation Of Establishment Of Protein Localization To Plasma Membrane Establishment Of Organelle Localization Exocytosis Positive Regulation Of Histone H3-K4 Methylation Negative Regulation Of Protein Localization To Plasma Membrane CAMP-mediated Signaling Regulation Of Histone H3-K4 Methylation Organelle Localization Cellular Response To Interleukin-6 Positive Regulation Of T-helper Cell Differentiation Cyclic-nucleotide-mediated Signaling Regulation Of Long-term Neuronal Synaptic Plasticity
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