MAP1A and RAPGEF4

Number of citations of the paper that reports this interaction (PMID 15202935)
9

Data Source:
HPRD (in vivo)

		MAP1A	RAPGEF4
Gene Name		microtubule-associated protein 1A	Rap guanine nucleotide exchange factor (GEF) 4
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Microtubule Microtubule Associated Complex	Cytosol Plasma Membrane CAMP-dependent Protein Kinase Complex Membrane
	Molecular Function	Structural Molecule Activity Protein Binding Microtubule Binding	Guanyl-nucleotide Exchange Factor Activity Ras Guanyl-nucleotide Exchange Factor Activity Protein Binding CAMP-dependent Protein Kinase Regulator Activity Ras GTPase Binding CAMP Binding
	Biological Process	Microtubule Cytoskeleton Organization Sensory Perception Of Sound	Energy Reserve Metabolic Process G-protein Coupled Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Blood Coagulation Calcium Ion-dependent Exocytosis Regulation Of Exocytosis CAMP-mediated Signaling Insulin Secretion Platelet Activation Positive Regulation Of Ras GTPase Activity Small Molecule Metabolic Process Regulation Of Protein Kinase Activity Regulation Of Insulin Secretion
Pathways			Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Rap1 signalling Integration of energy metabolism Regulation of insulin secretion Integrin alphaIIb beta3 signaling Platelet activation, signaling and aggregation Platelet Aggregation (Plug Formation) Adaptive Immune System
Drugs		Estramustine
Diseases
GWAS
Protein-Protein Interactions		22 interactors: ACTA1 ACTG1 AP1G1 ARHGEF11 CACNB4 DISC1 DLG1 DLG2 DLG4 GRB2 HTR2A KCNMA1 MAP1B MAP1LC3A NXF1 NXF2 RAPGEF3 RAPGEF4 SPP1 TUBA4A TUBB UPF2	11 interactors: ATXN1 BZRAP1 C16orf45 MAP1A RAP1A RAP2A RIMS2 RRAS2 SWAP70 TRAF2 ZC3H11A
Entrez ID		4130	11069
HPRD ID		02549	06929
Ensembl ID		ENSG00000166963	ENSG00000091428
Uniprot IDs		E9PGC8 P78559 Q504X9	B7Z283 Q8WZA2
PDB IDs
Enriched GO Terms of Interacting Partners?		Movement Of Cell Or Subcellular Component Cellular Localization Receptor Localization To Synapse Response To External Stimulus Cytoskeleton Organization Axonogenesis Axon Development Protein Localization To Synapse Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Platelet Activation Cell-cell Signaling Developmental Process Axon Guidance Neuron Projection Morphogenesis Muscle Contraction Blood Coagulation Hemostasis Cell Morphogenesis Involved In Differentiation Muscle System Process Establishment Of Localization In Cell Generation Of Neurons Neuron Projection Development Response To Stimulus Cell Projection Morphogenesis Neurogenesis Cell Part Morphogenesis Locomotion Multicellular Organismal Development Regulation Of Body Fluid Levels Cell Differentiation Synaptic Transmission Wound Healing System Development Nervous System Development Receptor Clustering Transport Neuron Development Cell Development Smooth Muscle Contraction Nucleotide Phosphorylation Establishment Or Maintenance Of Cell Polarity Cell Activation MRNA Export From Nucleus Cytoplasmic Transport Cellular Metal Ion Homeostasis Response To Wounding Cell Morphogenesis Organelle Organization Intracellular Transport	Rap Protein Signal Transduction Ras Protein Signal Transduction Negative Regulation Of Cell Motility Involved In Cerebral Cortex Radial Glia Guided Migration Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Postsynaptic Membrane Potential Intracellular Signal Transduction Neurotransmitter Secretion Membrane Depolarization Nuclear Export Regulation Of Neurotransmitter Levels Synaptic Transmission Regulation Of Phosphorylation Regulation Of Cell Migration Regulation Of Exocytosis Positive Regulation Of Inhibitory Postsynaptic Membrane Potential Regulation Of MAPK Cascade Small GTPase Mediated Signal Transduction Regulation Of JNK Cascade Regulation Of Cell Motility Neurotransmitter Transport Regulation Of Secretion Cellular Localization Negative Regulation Of Glial Cell Apoptotic Process Regulation Of Stress-activated MAPK Cascade Regulation Of Locomotion Regulation Of Phosphorus Metabolic Process Regulation Of Cellular Component Movement Regulation Of Neurogenesis Negative Regulation Of Cell Migration Positive Regulation Of Protein Phosphorylation Calcium Ion-dependent Exocytosis Of Neurotransmitter Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of Cell Motility Positive Regulation Of Protein Homodimerization Activity Negative Regulation Of Cellular Component Movement
Tagcloud ?		1b adapting apparently assign chain chains coimmunoprecipitation consisting cooh dimerize entire epitope filament flexible fragments harbor heavy homologous immunofluorescence light map1b maps microtubule microtubules nocodazole oligomerize tagged taxol transiently	adenylyl analog calr calreticulin camp chlorophenylthio cox2 cpt cyclase cyclooxygenase em1 endometrial epac epac2 establishment forskolin galactosidase glands glandular implantation lif pge2 phe pka prostaglandin ptgs2 receptivity silenced uterine
Tagcloud (Difference) ?		1b adapting apparently assign chain chains coimmunoprecipitation consisting cooh dimerize entire epitope filament flexible fragments harbor heavy homologous immunofluorescence light map1b maps microtubule microtubules nocodazole oligomerize tagged taxol transiently	adenylyl analog calr calreticulin camp chlorophenylthio cox2 cpt cyclase cyclooxygenase em1 endometrial epac epac2 establishment forskolin galactosidase glands glandular implantation lif pge2 phe pka prostaglandin ptgs2 receptivity silenced uterine
Tagcloud (Intersection) ?