MAP1A and DLG2

Number of citations of the paper that reports this interaction (PubMedID 9786987)
62

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		MAP1A	DLG2
Description		microtubule associated protein 1A	discs large MAGUK scaffold protein 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Microtubule Microtubule Associated Complex Axon Dendrite Neuron Projection Neuronal Cell Body Axon Initial Segment Dendritic Shaft Dendritic Branch Synapse Primary Dendrite Dendritic Microtubule Axon Cytoplasm	Cytosol Plasma Membrane Adherens Junction Voltage-gated Potassium Channel Complex Postsynaptic Density Membrane Basolateral Plasma Membrane Axon Neuromuscular Junction Cell Projection Neuron Projection Perikaryon Juxtaparanode Region Of Axon Synapse Postsynaptic Density Membrane Axon Cytoplasm
	Molecular Function	Actin Binding Structural Molecule Activity Protein Binding Microtubule Binding Cytoskeletal Anchor Activity Tubulin Binding Tau Protein Binding	GMP Kinase Activity Protein Binding Kinase Binding Protein Kinase Binding Ionotropic Glutamate Receptor Binding
	Biological Process	Microtubule Cytoskeleton Organization Axonogenesis Memory Associative Learning Dendrite Development Regulation Of Microtubule Depolymerization Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Synaptic Plasticity Voluntary Musculoskeletal Movement Neuron Cellular Homeostasis Anterograde Axonal Protein Transport Retrograde Axonal Protein Transport Negative Regulation Of Protein Localization To Microtubule Positive Regulation Of Protein Localization Neuron Projection Maintenance Positive Regulation Of Protein Localization To Cell Surface	Chemical Synaptic Transmission Nervous System Development Protein Localization To Synapse Cellular Response To Potassium Ion Receptor Clustering Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity GMP Metabolic Process GDP Metabolic Process Receptor Localization To Synapse Cell-cell Adhesion Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Anterograde Axonal Protein Transport Retrograde Axonal Protein Transport
Pathways			Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Ras activation upon Ca2+ influx through NMDA receptor RAF/MAP kinase cascade Neurexins and neuroligins Neurexins and neuroligins Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation
Drugs		Estramustine
Diseases
GWAS		Hemoglobin levels ( 32327693) Platelet count ( 27863252) Plateletcrit ( 27863252) Triglyceride levels x fish oil supplementation interaction (2df) ( 33760818) Triglycerides ( 24507774 30275531)	Adult body size ( 32376654) Age at first sexual intercourse ( 27089180) Attention function in attention deficit hyperactive disorder ( 26174813) BMI at adiposity rebound ( 31840077) Body fat mass ( 28552196) Body mass index ( 28552196) Brain morphology (MOSTest) ( 32665545) Cerebrospinal fluid t-tau:AB1-42 ratio ( 28641921) Chronic obstructive pulmonary disease ( 25584925) Chronic periodontitis ( 25008200) Estrogen level change in anastrozole-treated breast cancer ( 32701512) Familial squamous cell lung carcinoma ( 29924316) Femur bone mineral density x serum urate levels interaction ( 34046847) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Height ( 28552196) Influenza A (H1N1) infection ( 26379185) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Lung adenocarcinoma (survival time) in never smokers ( 32699080) Migraine without aura ( 28952330) Mild influenza (H1N1) infection ( 26379185) Modic changes ( 30808802) Myopia ( 27182965) Nicotine dependence symptom count ( 25555482) Obesity-related traits ( 23251661) Oily fish consumption ( 32066663) Pallidum volume ( 31530798) Parkinson's disease ( 32201043 32310270 28892059 28011712 25064009 17052657) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Phospholipid levels (plasma) ( 22359512) Pork consumption ( 32066663) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Protein quantitative trait loci ( 18464913) Putamen volume ( 29147026) Refractive error ( 32231278) Response to fenofibrate (triglyceride levels) ( 27002377) Response to TNF inhibitor in rheumatoid arthritis (change in swollen 28-joint count) ( 30166627) Schizophrenia ( 30285260) Schizophrenia x sex interaction ( 34099189) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Subcortical brain region volumes ( 25607358) Trunk fat mass ( 28552196) Type 2 diabetes ( 31049640) Urate levels in overweight individuals ( 25811787) Weight ( 28552196) Wilms tumor ( 22544364)
Interacting Genes		28 interacting genes: ACTA1 ACTG1 AP1G1 ARHGEF11 CACNB4 CSNK2A1 DISC1 DLG1 DLG2 DLG4 GRB2 HTR2A KCNMA1 MAP1B MAP1LC3A NXF1 NXF2 OGT PRKAR1A RAPGEF3 RAPGEF4 RHOB SFN SPP1 TUBA4A TUBB UPF2 WEE2-AS1	54 interacting genes: ABCA1 AOAH ATP2B2 ATP2B4 CACNG2 CNKSR2 CRIPT DLG1 DLG4 DLGAP1 DLGAP2 DLGAP3 DSCAM ERBB4 FA2H FASLG FZD1 FZD4 FZD7 GLS2 GRID1 GRID2 GRIN1 GRIN2A GRIN2B GRIN2D GUCY1A2 KCNA4 KCNJ12 KCNJ2 KCNJ4 KDELR1 KHDRBS1 KIF1B LIN7A LRP2 MAP1A MAPK12 NLGN1 NLGN2 NLGN3 NOS1 PLEKHA2 PPIL4 RNASE2 RPF2 RPS8 SCN4A SCN5A SEMA4C SERPINB13 VANGL2 VTN WNT3A
Entrez ID		4130	1740
HPRD ID		02549	04663
Ensembl ID		ENSG00000166963	ENSG00000150672
Uniprot IDs		E9PGC8 P78559 Q504X9	A0A3B3ISW2 A0A5F9ZH92 A0A994J570 A0A994J587 A0A994J5T6 A0A994J7P1 A0A994J7Q5 A0A994J819 A0A994J822 B5MCC5 B7Z2T4 E9PIJ9 E9PN83 Q15700
PDB IDs			2BYG 2HE2
Enriched GO Terms of Interacting Partners?		Synapse Cytosol Glutamatergic Synapse Protein Kinase Binding Intracellular Protein Localization Organelle Organization Cellular Localization Regulation Of Transport Establishment Or Maintenance Of Cell Polarity CAMP Binding Neuromuscular Junction Regulation Of Cellular Component Organization Protein Localization To Cell Junction Intracellular Transport Intracellular Signal Transduction Establishment Of Localization In Cell Regulation Of Biological Quality Ionotropic Glutamate Receptor Binding Microtubule Muscle Contraction Cytoskeleton Organization Structural Constituent Of Cytoskeleton Regulation Of Secretion By Cell Presynapse Axon Regulation Of Cell Growth Non-canonical Inflammasome Complex Assembly Muscle System Process Regulation Of Secretion Intracellular Signaling Cassette Postsynaptic Density Nuclear Export Odontoblast Differentiation Nuclear RNA Export Factor Complex Small GTPase-mediated Signal Transduction Positive Regulation Of Protein Localization Receptor Localization To Synapse Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Urinary Bladder Smooth Muscle Contraction Receptor Clustering Establishment Or Maintenance Of Apical/basal Cell Polarity GMP Kinase Activity Smooth Muscle Contraction Regulation Of Synapse Organization Protein Localization To Synapse Positive Regulation Of Cell Growth Chemical Synaptic Transmission GDP Metabolic Process Positive Regulation Of Supramolecular Fiber Organization Juxtaparanode Region Of Axon	Postsynaptic Density Membrane Synapse Glutamatergic Synapse Postsynaptic Membrane PDZ Domain Binding Regulation Of Membrane Potential Signaling Ionotropic Glutamate Receptor Signaling Pathway Positive Regulation Of Excitatory Postsynaptic Potential Positive Regulation Of Synaptic Transmission, Glutamatergic Cell Communication Synaptic Signaling Ligand-gated Ion Channel Signaling Pathway Chemical Synaptic Transmission Postsynaptic Density Trans-synaptic Signaling Modulation Of Chemical Synaptic Transmission Metal Ion Transport Modulation Of Excitatory Postsynaptic Potential Cell-cell Signaling Glutamate Receptor Signaling Pathway Plasma Membrane Regulation Of System Process Protein Localization To Synapse Monoatomic Ion Transport Dendritic Spine Scaffold Protein Binding Regulation Of Synaptic Transmission, Glutamatergic Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Regulation Of Signaling Regulation Of Cell Communication Regulation Of Synapse Organization Protein Localization To Cell Junction Presynapse Assembly Inorganic Cation Transmembrane Transport Monoatomic Cation Transmembrane Transport Ligand-gated Monoatomic Ion Channel Activity Positive Regulation Of Synaptic Transmission Transmembrane Transport Regulation Of Postsynaptic Membrane Potential Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Synapse Assembly Monoatomic Ion Channel Activity Inorganic Ion Transmembrane Transport NMDA Glutamate Receptor Activity Presynapse Organization Regulation Of Nervous System Process Calcium Ion Transport Synaptic Transmission, Glutamatergic
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