SH2B1 and IRS1

  • Number of citations of the paper that reports this interaction (PMID 22974441)
  • 2
  • Data Source:
  • BioGRID (unspecified method)

SH2B1

IRS1

Gene Name SH2B adaptor protein 1 insulin receptor substrate 1
Image No pdb structure
Gene Ontology Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions 12 interactors: EGFR FGFR3 GRB2 IGF1R INSR IRS1 JAK2 KIAA0319 NTRK1 NTRK2 RHBG SH2B2 73 interactors: AKT1 ALK AP3S1 APP ATP2A1 ATP2A2 ATP2A3 BCL2L1 BCR CAV1 CDH1 CHUK CRK CSNK2A1 CSNK2B EGFR ERBB2 FBXO25 FBXW8 FER FES FYN GHR GRB10 GRB14 GRB2 IGF1R IKBKB IL4R INSR JAK1 JAK2 JAK3 MAPK1 MAPK8 MAPK9 MTOR NCK2 NEDD4 NPM1 NTRK1 PDPK1 PHIP PIK3R1 PIK3R2 PIK3R3 PLCG2 PRKCD PRKCG PRKCQ PRKCZ PTK2 PTPN1 PTPN11 PTPRC PTPRF PTPRU RAD51 ROCK1 RPS6KB1 RPTOR SH2B1 SHC1 SIK2 SOCS1 SOCS3 TUB TYK2 UBTF YWHAB YWHAE YWHAG YWHAZ
Entrez ID 25970 3667
HPRD ID 12336 00943
Ensembl ID ENSG00000178188 ENSG00000169047
Uniprot IDs B3KNV5 B4DLN5 F5GXU7 Q9NRF2 P35568
PDB IDs 1IRS 1K3A 1QQG 2Z8C
Enriched GO Terms of Interacting Partners?
Tagcloud ?
actin  adapter  branching  depends  enhance  enhances  fact  filopoda  filopodia  filopodium  formation  hippocampal  initiation  insoluble  interacts  irsp53  isoform  localize  neurite  neurons  outgrowth  overexpressing  predominant  prerequisite  proline  regulate  rich  triton 
action  adipocytes  biochem  biophys  coimmunoprecipitation  coincided  commun  docking  evidenced  extent  gh  initiating  insulin  involvement  kda  kinase  phosphatidylinositol  phosphorylated  pi  postreceptor  res  ridderstrale  seems  substrate  thereby  tornqvist  tyrosine  wortmannin 
Tagcloud (Difference) ?
actin  adapter  branching  depends  enhance  enhances  fact  filopoda  filopodia  filopodium  formation  hippocampal  initiation  insoluble  interacts  irsp53  isoform  localize  neurite  neurons  outgrowth  overexpressing  predominant  prerequisite  proline  regulate  rich  triton 
action  adipocytes  biochem  biophys  coimmunoprecipitation  coincided  commun  docking  evidenced  extent  gh  initiating  insulin  involvement  kda  kinase  phosphatidylinositol  phosphorylated  pi  postreceptor  res  ridderstrale  seems  substrate  thereby  tornqvist  tyrosine  wortmannin 
Tagcloud (Intersection) ?