SH2B1 and IGF1R

Number of citations of the paper that reports this interaction (PMID 15767667)
21

Data Source:
BioGRID (two hybrid)

		SH2B1	IGF1R
Gene Name		SH2B adaptor protein 1	insulin-like growth factor 1 receptor
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytosol Membrane	Plasma Membrane Integral Component Of Plasma Membrane Caveola Membrane Neuron Projection Intracellular Membrane-bounded Organelle Receptor Complex
	Molecular Function	Signal Transducer Activity Protein Binding	G-protein Alpha-subunit Binding Protein Tyrosine Kinase Activity Insulin-like Growth Factor-activated Receptor Activity Insulin Receptor Binding Protein Binding Insulin-like Growth Factor Binding ATP Binding Insulin-like Growth Factor I Binding Identical Protein Binding Phosphatidylinositol 3-kinase Binding Insulin Binding Insulin Receptor Substrate Binding
	Biological Process	Movement Of Cell Or Subcellular Component Blood Coagulation Lamellipodium Assembly Intracellular Signal Transduction Positive Regulation Of Mitotic Nuclear Division Regulation Of DNA Biosynthetic Process	Immune Response Signal Transduction Axonogenesis Brain Development Positive Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Epidermis Development Negative Regulation Of Muscle Cell Apoptotic Process Phosphatidylinositol 3-kinase Signaling Establishment Of Cell Polarity Male Sex Determination Positive Regulation Of Cell Migration Mammary Gland Development Exocrine Pancreas Development Positive Regulation Of Cytokinesis Response To Vitamin E Peptidyl-tyrosine Autophosphorylation Negative Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of DNA Replication Positive Regulation Of Mitotic Nuclear Division Regulation Of JNK Cascade Protein Autophosphorylation Insulin-like Growth Factor Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Protein Tetramerization Protein Heterooligomerization Inactivation Of MAPKK Activity Positive Regulation Of Protein Kinase B Signaling Negative Regulation Of Protein Kinase B Signaling Prostate Gland Epithelium Morphogenesis Positive Regulation Of Steroid Hormone Biosynthetic Process
Pathways		Factors involved in megakaryocyte development and platelet production	IRS-related events triggered by IGF1R Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) SHC-related events triggered by IGF1R IGF1R signaling cascade
Drugs			Insulin Regular Insulin Lispro Insulin Glargine Insulin, porcine Mecasermin Alpha-D-Mannose Phosphoaminophosphonic Acid-Adenylate Ester (4Z)-6-bromo-4-({[4-(pyrrolidin-1-ylmethyl)phenyl]amino}methylidene)isoquinoline-1,3(2H,4H)-dione 3-[5-(1H-IMIDAZOL-1-YL)-7-METHYL-1H-BENZIMIDAZOL-2-YL]-4-[(PYRIDIN-2-YLMETHYL)AMINO]PYRIDIN-2(1H)-ONE
Diseases
GWAS		Body mass index ( 19079260 19079261 20935630) Crohn's disease ( 21102463) Obesity ( 23563607) Weight ( 19079260)	Arthritis (juvenile idiopathic) ( 22354554) Height ( 20881960) Urate levels ( 23263486)
Protein-Protein Interactions		12 interactors: EGFR FGFR3 GRB2 IGF1R INSR IRS1 JAK2 KIAA0319 NTRK1 NTRK2 RHBG SH2B2	59 interactors: AMY2A APP ARHGEF12 CAV1 CBL CRK CRKL CSK DOK4 DOK5 EEA1 EHD1 ESR1 FFAR2 GIPC1 GNAI1 GNAI2 GNB2L1 GRB10 GRB14 IGF1 IGF2 IGFBP3 INS INSR IRS1 IRS2 IRS4 ITGB1 JAK1 JAK2 KCNIP3 KL KRT27 MAP3K5 MDM2 NEDD4 PIK3R1 PIK3R2 PIK3R3 PRKCD PRKD1 PTPN1 PTPN11 RASA1 RPL11 SH2B1 SHC1 SOCS1 SOCS2 SOCS3 SRC STAT3 UBC VAV3 YWHAB YWHAE YWHAG YWHAZ
Entrez ID		25970	3480
HPRD ID		12336	00932
Ensembl ID		ENSG00000178188	ENSG00000140443
Uniprot IDs		B3KNV5 B4DLN5 F5GXU7 Q9NRF2	C9J5X1 P08069
PDB IDs			1IGR 1JQH 1K3A 1M7N 1P4O 2OJ9 2ZM3 3D94 3F5P 3I81 3LVP 3LW0 3NW5 3NW6 3NW7 3O23 3QQU
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Organonitrogen Compound Enzyme Linked Receptor Protein Signaling Pathway Protein Autophosphorylation Positive Regulation Of Signal Transduction Response To Organonitrogen Compound Peptidyl-tyrosine Phosphorylation Phosphatidylinositol-mediated Signaling Cellular Response To Peptide Hormone Stimulus Insulin Receptor Signaling Pathway Cellular Response To Hormone Stimulus Cellular Response To Peptide Regulation Of MAPK Cascade Cellular Response To Insulin Stimulus Neurotrophin TRK Receptor Signaling Pathway Intracellular Signal Transduction Positive Regulation Of MAPK Cascade Cellular Response To Organic Substance Neurotrophin Signaling Pathway Response To Peptide Hormone Regulation Of Phosphorylation Response To Peptide Positive Regulation Of Phosphorylation Regulation Of Phosphorus Metabolic Process Response To Hormone Response To Insulin Cellular Response To Growth Factor Stimulus Response To Growth Factor Response To Organic Substance Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Regulation Of Kinase Activity Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Proliferation System Development Positive Regulation Of Kinase Activity Regulation Of Signaling Positive Regulation Of Reactive Oxygen Species Metabolic Process Cell Surface Receptor Signaling Pathway Regulation Of Cell Proliferation Peptidyl-amino Acid Modification Neuron Development Nervous System Development Generation Of Neurons Positive Regulation Of Transferase Activity Positive Regulation Of Synaptic Transmission, Glutamatergic Axon Development Multicellular Organismal Development Neurogenesis Regulation Of Protein Phosphorylation	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Signaling Cellular Response To Peptide Hormone Stimulus Regulation Of Signal Transduction Cellular Response To Peptide Cell Surface Receptor Signaling Pathway Response To Peptide Hormone Regulation Of Phosphorylation Cellular Response To Organic Substance Regulation Of Phosphorus Metabolic Process Response To Peptide Regulation Of Kinase Activity Cellular Response To Organonitrogen Compound Signal Transduction Signaling Response To Organic Substance Cellular Response To Hormone Stimulus Cell Communication Response To Hormone Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Blood Coagulation Hemostasis Cellular Response To Stimulus Cellular Response To Insulin Stimulus Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Response To Organonitrogen Compound Insulin Receptor Signaling Pathway Response To Growth Factor Wound Healing Regulation Of Catalytic Activity Regulation Of Protein Phosphorylation Cellular Response To Growth Factor Stimulus Regulation Of Body Fluid Levels Response To Insulin Response To Stress Response To Wounding Regulation Of Protein Kinase Activity Defense Response Positive Regulation Of Phosphorylation Positive Regulation Of Intracellular Signal Transduction Innate Immune Response Regulation Of MAPK Cascade Response To Stimulus Positive Regulation Of Transport Regulation Of Immune Response Regulation Of Cell Death
Tagcloud ?		actin adapter branching depends enhance enhances fact filopoda filopodia filopodium formation hippocampal initiation insoluble interacts irsp53 isoform localize neurite neurons outgrowth overexpressing predominant prerequisite proline regulate rich triton	12q 12q21 14q31 15q25 16q23 18p 19q13 20p12 20pq 20q12 21q21 3p14 4pq 5p14 5q14 6p12 7p12 8q23 cardia cdkn2 fist gej mlvi2 mts1 nrasl3 parentheses ptpn1 rca1 xpq xq25
Tagcloud (Difference) ?		actin adapter branching depends enhance enhances fact filopoda filopodia filopodium formation hippocampal initiation insoluble interacts irsp53 isoform localize neurite neurons outgrowth overexpressing predominant prerequisite proline regulate rich triton	12q 12q21 14q31 15q25 16q23 18p 19q13 20p12 20pq 20q12 21q21 3p14 4pq 5p14 5q14 6p12 7p12 8q23 cardia cdkn2 fist gej mlvi2 mts1 nrasl3 parentheses ptpn1 rca1 xpq xq25
Tagcloud (Intersection) ?