SH2B1 and KIAA0319

Number of citations of the paper that reports this interaction (PMID 12421765)
28

Data Source:
HPRD (two hybrid)

		SH2B1	KIAA0319
Gene Name		SH2B adaptor protein 1	KIAA0319
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytosol Membrane	Early Endosome Plasma Membrane Integral Component Of Membrane Early Endosome Membrane
	Molecular Function	Signal Transducer Activity Protein Binding	Protein Binding
	Biological Process	Movement Of Cell Or Subcellular Component Blood Coagulation Lamellipodium Assembly Intracellular Signal Transduction Positive Regulation Of Mitotic Nuclear Division Regulation Of DNA Biosynthetic Process	Neuron Migration Negative Regulation Of Dendrite Development
Pathways		Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Body mass index ( 19079260 19079261 20935630) Crohn's disease ( 21102463) Obesity ( 23563607) Weight ( 19079260)	Radiation response ( 20923822)
Protein-Protein Interactions		12 interactors: EGFR FGFR3 GRB2 IGF1R INSR IRS1 JAK2 KIAA0319 NTRK1 NTRK2 RHBG SH2B2	2 interactors: FEM1B SH2B1
Entrez ID		25970	9856
HPRD ID		12336	18713
Ensembl ID		ENSG00000178188	ENSG00000137261
Uniprot IDs		B3KNV5 B4DLN5 F5GXU7 Q9NRF2	Q5VV43
PDB IDs			2E7M
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Organonitrogen Compound Enzyme Linked Receptor Protein Signaling Pathway Protein Autophosphorylation Positive Regulation Of Signal Transduction Response To Organonitrogen Compound Peptidyl-tyrosine Phosphorylation Phosphatidylinositol-mediated Signaling Cellular Response To Peptide Hormone Stimulus Insulin Receptor Signaling Pathway Cellular Response To Hormone Stimulus Cellular Response To Peptide Regulation Of MAPK Cascade Cellular Response To Insulin Stimulus Neurotrophin TRK Receptor Signaling Pathway Intracellular Signal Transduction Positive Regulation Of MAPK Cascade Cellular Response To Organic Substance Neurotrophin Signaling Pathway Response To Peptide Hormone Regulation Of Phosphorylation Response To Peptide Positive Regulation Of Phosphorylation Regulation Of Phosphorus Metabolic Process Response To Hormone Response To Insulin Cellular Response To Growth Factor Stimulus Response To Growth Factor Response To Organic Substance Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Regulation Of Kinase Activity Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Proliferation System Development Positive Regulation Of Kinase Activity Regulation Of Signaling Positive Regulation Of Reactive Oxygen Species Metabolic Process Cell Surface Receptor Signaling Pathway Regulation Of Cell Proliferation Peptidyl-amino Acid Modification Neuron Development Nervous System Development Generation Of Neurons Positive Regulation Of Transferase Activity Positive Regulation Of Synaptic Transmission, Glutamatergic Axon Development Multicellular Organismal Development Neurogenesis Regulation Of Protein Phosphorylation	Epithelial Cell Maturation Involved In Prostate Gland Development Regulation Of Cell Cycle Process Regulation Of DNA Damage Checkpoint Epithelial Cell Differentiation Involved In Prostate Gland Development Regulation Of Cell Cycle Branching Involved In Prostate Gland Morphogenesis Epithelial Cell Maturation Regulation Of Cell Cycle Checkpoint Prostate Gland Epithelium Morphogenesis Positive Regulation Of Mitotic Nuclear Division Prostate Gland Morphogenesis Regulation Of DNA Biosynthetic Process Lamellipodium Assembly Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Lamellipodium Organization Prostate Gland Development Regulation Of Ubiquitin-protein Transferase Activity
Tagcloud ?		actin adapter branching depends enhance enhances fact filopoda filopodia filopodium formation hippocampal initiation insoluble interacts irsp53 isoform localize neurite neurons outgrowth overexpressing predominant prerequisite proline regulate rich triton	6p acetylated alleles arrays chip contributing covering dcdc2 differential disabilities encompassed haplotype histones indicates intron kb located mapped markers narrowing opposite pointing rd rds reading region strongest tiling vmp
Tagcloud (Difference) ?		actin adapter branching depends enhance enhances fact filopoda filopodia filopodium formation hippocampal initiation insoluble interacts irsp53 isoform localize neurite neurons outgrowth overexpressing predominant prerequisite proline regulate rich triton	6p acetylated alleles arrays chip contributing covering dcdc2 differential disabilities encompassed haplotype histones indicates intron kb located mapped markers narrowing opposite pointing rd rds reading region strongest tiling vmp
Tagcloud (Intersection) ?