SH2B1 and RHBG

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		SH2B1	RHBG
Gene Name		SH2B adaptor protein 1	Rh family, B glycoprotein (gene/pseudogene)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytosol Membrane	Plasma Membrane Integral Component Of Plasma Membrane Spectrin-associated Cytoskeleton Basolateral Plasma Membrane Cytoplasmic Vesicle Membrane Anchored Component Of Plasma Membrane
	Molecular Function	Signal Transducer Activity Protein Binding	Ammonium Transmembrane Transporter Activity Ankyrin Binding
	Biological Process	Movement Of Cell Or Subcellular Component Blood Coagulation Lamellipodium Assembly Intracellular Signal Transduction Positive Regulation Of Mitotic Nuclear Division Regulation Of DNA Biosynthetic Process	Ammonium Transport Transmembrane Transport Transepithelial Ammonium Transport Ammonium Transmembrane Transport
Pathways		Factors involved in megakaryocyte development and platelet production	Rhesus glycoproteins mediate ammonium transport. Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds SLC-mediated transmembrane transport
Drugs
Diseases
GWAS		Body mass index ( 19079260 19079261 20935630) Crohn's disease ( 21102463) Obesity ( 23563607) Weight ( 19079260)	Subcutaneous adipose tissue ( 22589738) Visceral adipose tissue adjusted for BMI ( 22589738)
Protein-Protein Interactions		12 interactors: EGFR FGFR3 GRB2 IGF1R INSR IRS1 JAK2 KIAA0319 NTRK1 NTRK2 RHBG SH2B2	1 interactors: SH2B1
Entrez ID		25970	57127
HPRD ID		12336	06152
Ensembl ID		ENSG00000178188	ENSG00000132677
Uniprot IDs		B3KNV5 B4DLN5 F5GXU7 Q9NRF2	Q9H310
PDB IDs
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Organonitrogen Compound Enzyme Linked Receptor Protein Signaling Pathway Protein Autophosphorylation Positive Regulation Of Signal Transduction Response To Organonitrogen Compound Peptidyl-tyrosine Phosphorylation Phosphatidylinositol-mediated Signaling Cellular Response To Peptide Hormone Stimulus Insulin Receptor Signaling Pathway Cellular Response To Hormone Stimulus Cellular Response To Peptide Regulation Of MAPK Cascade Cellular Response To Insulin Stimulus Neurotrophin TRK Receptor Signaling Pathway Intracellular Signal Transduction Positive Regulation Of MAPK Cascade Cellular Response To Organic Substance Neurotrophin Signaling Pathway Response To Peptide Hormone Regulation Of Phosphorylation Response To Peptide Positive Regulation Of Phosphorylation Regulation Of Phosphorus Metabolic Process Response To Hormone Response To Insulin Cellular Response To Growth Factor Stimulus Response To Growth Factor Response To Organic Substance Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Regulation Of Kinase Activity Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Proliferation System Development Positive Regulation Of Kinase Activity Regulation Of Signaling Positive Regulation Of Reactive Oxygen Species Metabolic Process Cell Surface Receptor Signaling Pathway Regulation Of Cell Proliferation Peptidyl-amino Acid Modification Neuron Development Nervous System Development Generation Of Neurons Positive Regulation Of Transferase Activity Positive Regulation Of Synaptic Transmission, Glutamatergic Axon Development Multicellular Organismal Development Neurogenesis Regulation Of Protein Phosphorylation	Positive Regulation Of Mitotic Nuclear Division Regulation Of DNA Biosynthetic Process Lamellipodium Assembly Lamellipodium Organization Positive Regulation Of Mitotic Cell Cycle Regulation Of Mitotic Nuclear Division Positive Regulation Of Cell Division Positive Regulation Of Cell Cycle Process Regulation Of Cell Division Positive Regulation Of Cell Cycle Cell Projection Assembly
Tagcloud ?		actin adapter branching depends enhance enhances fact filopoda filopodia filopodium formation hippocampal initiation insoluble interacts irsp53 isoform localize neurite neurons outgrowth overexpressing predominant prerequisite proline regulate rich triton	ae ammonium anchoring ankyrin band basolateral bilayer biosynthesis challenge constitutes emerging erythroid gpc member membrane mutated next null observations p55 polarized red rhag similarly skeleton spectrin summarize weak
Tagcloud (Difference) ?		actin adapter branching depends enhance enhances fact filopoda filopodia filopodium formation hippocampal initiation insoluble interacts irsp53 isoform localize neurite neurons outgrowth overexpressing predominant prerequisite proline regulate rich triton	ae ammonium anchoring ankyrin band basolateral bilayer biosynthesis challenge constitutes emerging erythroid gpc member membrane mutated next null observations p55 polarized red rhag similarly skeleton spectrin summarize weak
Tagcloud (Intersection) ?