SH2B1 and RHBG

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		SH2B1	RHBG
Description		SH2B adaptor protein 1	Rh family B glycoprotein
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Membrane	Plasma Membrane Spectrin-associated Cytoskeleton Membrane Basolateral Plasma Membrane
	Molecular Function	Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Protein Binding Signaling Adaptor Activity	Protein Binding Ammonium Channel Activity Ankyrin Binding Carbon Dioxide Transmembrane Transporter Activity
	Biological Process	Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Lamellipodium Assembly Intracellular Signal Transduction Positive Regulation Of Mitotic Nuclear Division Cell Motility Positive Regulation Of SMAD Protein Signal Transduction Regulation Of DNA Biosynthetic Process	Carbon Dioxide Transmembrane Transport Transepithelial Ammonium Transport Ammonium Transmembrane Transport Ammonium Homeostasis
Pathways		Factors involved in megakaryocyte development and platelet production	Rhesus glycoproteins mediate ammonium transport
Drugs
Diseases
GWAS		Adult body size ( 32376654) Angiotensin-converting enzyme inhibitor intolerance ( 28030426) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body fat percentage ( 26833246) Body mass index ( 19079260 29381148 28448500 19079261 20935630) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically active individuals ( 28448500) Body size at age 10 ( 32376654) Brain morphology (MOSTest) ( 32665545) Cognitive ability ( 29186694) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Crohn's disease ( 28067908 21102463) Dental caries (decayed, missing and filled teeth) ( 31533690) Educational attainment ( 25201988) Extremely high intelligence ( 29520040) General cognitive ability ( 29844566) General risk tolerance (MTAG) ( 30643258) Hand grip strength ( 29691431) Inflammatory bowel disease ( 28067908) Intelligence ( 28530673) Lamb consumption ( 32066663) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Obesity ( 23563607) QT interval ( 29213071) Red blood cell count ( 32888494 27863252) Waist circumference ( 25673412) Weight ( 19079260)	Initial pursuit acceleration ( 29064472) Subcutaneous adipose tissue ( 22589738) Visceral adipose tissue adjusted for BMI ( 22589738)
Interacting Genes		19 interacting genes: CRK CSAD EGFR ERBB2 ERBB3 ERBB4 FGFR3 FRS3 GRB2 HUNK IGF1R INSR JAK2 KIAA0319 MET NTRK1 NTRK2 RHBG SH2B2	4 interacting genes: CYSRT1 KRTAP19-1 KRTAP19-2 SH2B1
Entrez ID		25970	57127
HPRD ID		12336	06152
Ensembl ID		ENSG00000178188	ENSG00000132677
Uniprot IDs		B3KNV5 B4DLN5 Q9NRF2	Q9H310
PDB IDs		5W3R
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Enzyme-linked Receptor Protein Signaling Pathway Receptor Complex Protein Kinase Activity Kinase Activity Positive Regulation Of MAPK Cascade Regulation Of MAPK Cascade Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cell Surface Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Insulin Receptor Substrate Binding Peptidyl-tyrosine Phosphorylation ATP Binding Protein Autophosphorylation Epidermal Growth Factor Receptor Signaling Pathway Basal Plasma Membrane ERBB2 Signaling Pathway Positive Regulation Of Signal Transduction Cellular Response To Growth Factor Stimulus Plasma Membrane ERBB Signaling Pathway Nucleotide Binding Transferase Activity Response To Growth Factor Positive Regulation Of Cell Communication Positive Regulation Of Signaling Protein Phosphorylation Neuron Differentiation Signal Transduction Phosphorylation Regulation Of Signal Transduction Cell Development Negative Regulation Of Programmed Cell Death Positive Regulation Of Cell Population Proliferation Identical Protein Binding Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Endosome Regulation Of Cell Communication Regulation Of Signaling Phosphatidylinositol 3-kinase Binding Cellular Developmental Process Positive Regulation Of Phosphate Metabolic Process Schwann Cell Development ERBB3:ERBB2 Complex Regulation Of Catalytic Activity Regulation Of Peptidyl-tyrosine Phosphorylation	Intermediate Filament
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