SH2B1 and NTRK2

Number of citations of the paper that reports this interaction (PMID 9856458)
52

Data Source:
HPRD (in vitro)

		SH2B1	NTRK2
Gene Name		SH2B adaptor protein 1	neurotrophic tyrosine kinase, receptor, type 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytosol Membrane	Rough Endoplasmic Reticulum Cytosol Integral Component Of Plasma Membrane Cell Surface Endosome Membrane Growth Cone Terminal Bouton Dendritic Spine Perikaryon Receptor Complex Postsynaptic Membrane Presynaptic Active Zone Excitatory Synapse Neuronal Postsynaptic Density
	Molecular Function	Signal Transducer Activity Protein Binding	ATP Binding Protein Homodimerization Activity Neurotrophin Binding Ephrin Receptor Binding Brain-derived Neurotrophic Factor Binding Brain-derived Neurotrophic Factor-activated Receptor Activity
	Biological Process	Movement Of Cell Or Subcellular Component Blood Coagulation Lamellipodium Assembly Intracellular Signal Transduction Positive Regulation Of Mitotic Nuclear Division Regulation Of DNA Biosynthetic Process	Vasculogenesis Neuron Migration Inflammatory Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Activation Of Adenylate Cyclase Activity Neuromuscular Junction Development Aging Learning Long-term Memory Circadian Rhythm Feeding Behavior Positive Regulation Of Cell Proliferation Response To Light Stimulus Positive Regulation Of Gene Expression Positive Regulation Of Neuron Projection Development Response To Auditory Stimulus Glutamate Secretion Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Peptidyl-tyrosine Phosphorylation Central Nervous System Neuron Development Cerebral Cortex Development Neuron Differentiation Brain-derived Neurotrophic Factor Receptor Signaling Pathway Regulation Of Rac GTPase Activity Positive Regulation Of Peptidyl-serine Phosphorylation Calcium-mediated Signaling Using Intracellular Calcium Source Mechanoreceptor Differentiation Positive Regulation Of MAPK Cascade Negative Regulation Of Neuron Apoptotic Process Retinal Rod Cell Development Protein Autophosphorylation Regulation Of Neurotransmitter Secretion Neurotrophin TRK Receptor Signaling Pathway Oligodendrocyte Differentiation Peripheral Nervous System Neuron Development Positive Regulation Of Axonogenesis Regulation Of Dendrite Development Regulation Of Protein Kinase B Signaling Positive Regulation Of Synaptic Transmission, Glutamatergic Long-term Synaptic Potentiation Cellular Response To Tumor Necrosis Factor Cellular Response To Nerve Growth Factor Stimulus Negative Regulation Of Anoikis
Pathways		Factors involved in megakaryocyte development and platelet production	Signalling by NGF Activation of TRKA receptors NGF-independant TRKA activation NGF signalling via TRKA from the plasma membrane
Drugs
Diseases
GWAS		Body mass index ( 19079260 19079261 20935630) Crohn's disease ( 21102463) Obesity ( 23563607) Weight ( 19079260)	Waist-to-hip circumference ratio (interaction) ( 23192594)
Protein-Protein Interactions		12 interactors: EGFR FGFR3 GRB2 IGF1R INSR IRS1 JAK2 KIAA0319 NTRK1 NTRK2 RHBG SH2B2	29 interactors: AP1B1 BDNF DOK5 DYNLL1 FRS2 FRS3 FYN GIPC1 KIDINS220 NCK1 NCK2 NGFR NMNAT1 NTF3 NTF4 PIK3R1 PLCG1 POLR2G PTPN1 PTPN11 RASGRF1 SH2B1 SH2B2 SHC1 SHC2 SHC3 SQSTM1 TRAF6 UBB
Entrez ID		25970	4915
HPRD ID		12336	02712
Ensembl ID		ENSG00000178188	ENSG00000148053
Uniprot IDs		B3KNV5 B4DLN5 F5GXU7 Q9NRF2	Q16620 Q548C2 Q5VWE5
PDB IDs			1HCF 1WWB 4ASZ 4AT3 4AT4 4AT5
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Organonitrogen Compound Enzyme Linked Receptor Protein Signaling Pathway Protein Autophosphorylation Positive Regulation Of Signal Transduction Response To Organonitrogen Compound Peptidyl-tyrosine Phosphorylation Phosphatidylinositol-mediated Signaling Cellular Response To Peptide Hormone Stimulus Insulin Receptor Signaling Pathway Cellular Response To Hormone Stimulus Cellular Response To Peptide Regulation Of MAPK Cascade Cellular Response To Insulin Stimulus Neurotrophin TRK Receptor Signaling Pathway Intracellular Signal Transduction Positive Regulation Of MAPK Cascade Cellular Response To Organic Substance Neurotrophin Signaling Pathway Response To Peptide Hormone Regulation Of Phosphorylation Response To Peptide Positive Regulation Of Phosphorylation Regulation Of Phosphorus Metabolic Process Response To Hormone Response To Insulin Cellular Response To Growth Factor Stimulus Response To Growth Factor Response To Organic Substance Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Regulation Of Kinase Activity Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Proliferation System Development Positive Regulation Of Kinase Activity Regulation Of Signaling Positive Regulation Of Reactive Oxygen Species Metabolic Process Cell Surface Receptor Signaling Pathway Regulation Of Cell Proliferation Peptidyl-amino Acid Modification Neuron Development Nervous System Development Generation Of Neurons Positive Regulation Of Transferase Activity Positive Regulation Of Synaptic Transmission, Glutamatergic Axon Development Multicellular Organismal Development Neurogenesis Regulation Of Protein Phosphorylation	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Positive Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Signal Transduction Signaling Cell Communication Regulation Of Phosphorylation Cellular Response To Stimulus Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Signaling Regulation Of Signal Transduction Regulation Of Phosphorus Metabolic Process Regulation Of Kinase Activity Regulation Of Protein Metabolic Process Intracellular Signal Transduction Cellular Response To Organic Substance Regulation Of Protein Phosphorylation Nervous System Development Insulin Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Protein Kinase Activity Activation Of Protein Kinase Activity Fc Receptor Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Positive Regulation Of Intracellular Signal Transduction Response To Stimulus Cellular Response To Peptide Hormone Stimulus Neuron Projection Development Cellular Response To Peptide Cellular Response To Organonitrogen Compound Neuron Projection Morphogenesis Regulation Of Cellular Protein Metabolic Process Immune Response-regulating Signaling Pathway Cellular Response To Insulin Stimulus Positive Regulation Of Cellular Protein Metabolic Process Cell Projection Organization Fc-epsilon Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Activation Of MAPK Activity Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Protein Phosphorylation Response To Organic Substance
Tagcloud ?		actin adapter branching depends enhance enhances fact filopoda filopodia filopodium formation hippocampal initiation insoluble interacts irsp53 isoform localize neurite neurons outgrowth overexpressing predominant prerequisite proline regulate rich triton	a432t a452v ankk1 arrb2 cdh13 chrna2 chrna9 dbh dnm1 drd2 eas fagerstrom gabbr2 grin3a mstcc n549s nrxn1 nrxn2 nrxn3 r480h rs139982841 rs142807401 rs34755188 rs75981117 skat tas2r38 v132l v389l wss
Tagcloud (Difference) ?		actin adapter branching depends enhance enhances fact filopoda filopodia filopodium formation hippocampal initiation insoluble interacts irsp53 isoform localize neurite neurons outgrowth overexpressing predominant prerequisite proline regulate rich triton	a432t a452v ankk1 arrb2 cdh13 chrna2 chrna9 dbh dnm1 drd2 eas fagerstrom gabbr2 grin3a mstcc n549s nrxn1 nrxn2 nrxn3 r480h rs139982841 rs142807401 rs34755188 rs75981117 skat tas2r38 v132l v389l wss
Tagcloud (Intersection) ?