DCAF13 and TK1

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		DCAF13	TK1
Description		DDB1 and CUL4 associated factor 13	thymidine kinase 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Centrosome Cytosol Cell Junction Small-subunit Processome Cul4-RING E3 Ubiquitin Ligase Complex Ribonucleoprotein Complex	Nucleus Cytoplasm Cytosol
	Molecular Function	RNA Binding Protein Binding Nuclear Estrogen Receptor Binding Ubiquitin-like Ligase-substrate Adaptor Activity	Nucleotide Binding Thymidine Kinase Activity Protein Binding ATP Binding Zinc Ion Binding Kinase Activity Transferase Activity Identical Protein Binding Metal Ion Binding
	Biological Process	Maturation Of SSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Oocyte Growth RRNA Processing Spindle Assembly Involved In Female Meiosis Female Gamete Generation Protein Ubiquitination Ribosome Biogenesis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Epigenetic Programming In The Zygotic Pronuclei Decidualization Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction	Nucleobase-containing Compound Metabolic Process Deoxyribonucleoside Monophosphate Biosynthetic Process Thymidine Metabolic Process Thymidine Biosynthetic Process Protein Homotetramerization DNA Biosynthetic Process DNA Synthesis Involved In Mitotic DNA Replication
Pathways		rRNA modification in the nucleus and cytosol Major pathway of rRNA processing in the nucleolus and cytosol Neddylation	G1/S-Specific Transcription Pyrimidine salvage
Drugs			Dithioerythritol Thymidine 5'-triphosphate
Diseases
GWAS			Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Leukocyte telomere length ( 32109421) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular volume ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red cell distribution width ( 27863252 28957414 32888494)
Interacting Genes		4 interacting genes: PTEN TK1 USP2-AS1 WARS1	166 interacting genes: A1BG A2M AAMP ABHD4 ACTB ACTL6B ACTR1B ADAMTS10 ADD1 AGAP1 ALAS1 ALB APLP1 APP ARFGAP1 ATG16L2 ATP5F1B ATP6V1A ATXN3 BAG6 BOLA2 BOLA2B CARHSP1 CCDC90B CDC20 CDK1 CDK4 CDKN1A CENPB CFTR CHGB CLEC3B COL11A2 COL4A2 COL4A5 COPS6 CPNE6 CRIP2 CRMP1 CSAD DACT1 DALRD3 DCAF13 DDAH2 DEAF1 DMPK DOCK7 DRAP1 DUS2 DYNC1I1 DYNC2I1 DYNLT2B EEF1A1 EIF3G EIF4A2 EIF6 ERG28 EXT2 EZH2 F13A1 FAF1 FAM20C FBN3 FGB FLAD1 FST FZR1 GAPDH GDF9 GDI1 GET3 GLB1 GPCPD1 HADHB HERC3 HMGXB3 HSPBAP1 IER3IP1 IGHM IMMT INPP5K INTS11 ITSN1 JADE1 JMJD1C KDM6B KIF21B KIF5A KLHL23 KLHL5 KMT2B LRIF1 MAGEA4 MAST2 MED31 METTL23 MKI67 MPP1 MPPED1 MRFAP1 MRPL20-AS1 MRPL37 MSH2 NEUROD2 NGFR NKIRAS2 NMT2 NRBP1 ODC1 PAAF1 PDE4DIP PJA1 PKM PLD3 PLXNA3 PPP4C PRMT1 PROC PSME1 PTPN4 PTPRK QARS1 RBBP4 RBM48 REX1BD RPA1 RPL13 RPS2 RUVBL1 RXRA SDF4 SEMA5B SEPTIN6 SETDB1 SEZ6L2 SMC5 SNX1 SP110 SULT1A3 SUMO2 SUMO3 TAF1C THOC3 TIAM2 TLE1 TMSB4X TP53 TRIM46 TRMT2A TSC2 TTC38 TUBA1A TUBB2A TUBB3 TYK2 UBC UNC119 UPF2 USP4 VMA22 WDR18 WDR73 WIZ ZBTB16 ZNF431 ZXDC
Entrez ID		25879	7083
HPRD ID		08528	01771
Ensembl ID		ENSG00000164934	ENSG00000167900
Uniprot IDs		A0A087WT20 Q9NV06	A0A384MDV9 K7ERV3 K7ES52 P04183
PDB IDs		7MQ8 7MQ9 7MQA	1W4R 1XBT 2ORV 2WVJ
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Synaptic Vesicle Clustering Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Central Nervous System Myelin Maintenance Negative Regulation Of Phosphorylation Negative Regulation Of Protein Phosphorylation Rhythmic Synaptic Transmission Negative Regulation Of Phosphate Metabolic Process Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity DNA Synthesis Involved In Mitotic DNA Replication Thymidine Kinase Activity Tryptophan-tRNA Ligase Activity Tryptophanyl-tRNA Aminoacylation Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase Activity Myelin Sheath Adaxonal Region Negative Regulation Of Wound Healing, Spreading Of Epidermal Cells Phosphatidylinositol Phosphate Phosphatase Activity Thymidine Biosynthetic Process MCRD-mediated MRNA Stability Complex Negative Regulation Of Peptidyl-serine Phosphorylation Regulation Of Synaptic Vesicle Clustering Postsynaptic Density Assembly Thymidine Metabolic Process Kinase Inhibitor Activity Locomotor Rhythm Phosphatidylinositol-3-phosphate Phosphatase Activity Cellular Response To Electrical Stimulus Ubiquitin Ligase Activator Activity Spindle Assembly Involved In Female Meiosis Postsynaptic Specialization Assembly Prepulse Inhibition Neuron-neuron Synaptic Transmission Negative Regulation Of Cell Size Maternal Behavior Presynaptic Membrane Organization Schmidt-Lanterman Incisure Anaphase-promoting Complex Binding Forebrain Morphogenesis Negative Regulation Of Excitatory Postsynaptic Potential Presynaptic Membrane Assembly Pyrimidine Nucleoside Metabolic Process Deoxyribonucleoside Monophosphate Biosynthetic Process Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Translation Activator Activity Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay CRD-mediated MRNA Stabilization Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay	Cytoplasm Macromolecule Metabolic Process Protein Metabolic Process Platelet Alpha Granule Lumen Chromatin Organization Blood Microparticle Negative Regulation Of Cell Cycle G1/S Phase Transition Chromatin Remodeling Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Extracellular Exosome Cytosol Regulation Of DNA Replication Regulation Of G1/S Transition Of Mitotic Cell Cycle Protein Binding Nucleoplasm Positive Regulation Of Protein Catabolic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Ubiquitin-protein Transferase Activity Nuclear Matrix Regulation Of Protein Catabolic Process DNA Synthesis Involved In Mitotic DNA Replication Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Macromolecule Biosynthetic Process Chromosome, Telomeric Region Positive Regulation Of Protein Metabolic Process Cytoskeleton Negative Regulation Of Cell Cycle Process Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Protein Tag Activity Developmental Process Growth Cone Protein Modification Process Cellular Response To Norepinephrine Stimulus Response To Norepinephrine Mitotic DNA Damage Checkpoint Signaling Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Oocyte Growth
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