SHPRH and RAD18

Number of citations of the paper that reports this interaction (PubMedID 25023518)
50

Data Source:
BioGRID (pull down)

		SHPRH	RAD18
Description		SNF2 histone linker PHD RING helicase	RAD18 E3 ubiquitin protein ligase
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GO Annotations	Cellular Component	Nucleosome Nucleus Nucleoplasm	Nucleus Nucleoplasm Replication Fork Chromosome Cytoplasm Centrosome Cytoskeleton Nuclear Body Site Of Double-strand Break Nuclear Inclusion Body Rad6-Rad18 Complex
	Molecular Function	Nucleotide Binding DNA Binding Helicase Activity Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Zinc Ion Binding Transferase Activity Hydrolase Activity Ubiquitin Protein Ligase Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Y-form DNA Binding DNA Binding Damaged DNA Binding Single-stranded DNA Binding Protein Binding Zinc Ion Binding Transferase Activity Polyubiquitin Modification-dependent Protein Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Protein-containing Complex Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Protein Polyubiquitination DNA Repair Nucleosome Assembly DNA Damage Response Protein Ubiquitination	DNA Repair Postreplication Repair Protein Monoubiquitination DNA Damage Response Protein Ubiquitination Protein Autoubiquitination Positive Regulation Of Chromosome Segregation
Pathways		E3 ubiquitin ligases ubiquitinate target proteins	Recognition of DNA damage by PCNA-containing replication complex E3 ubiquitin ligases ubiquitinate target proteins
Drugs
Diseases
GWAS			Chronotype ( 30696823) Clopidogrel active metabolite levels ( 28207573) Metabolite levels ( 23823483) Morning person ( 30696823) Sleep duration ( 30531941) Transverse temporal cortex volume ( 31530798) Triglyceride levels ( 34074324)
Interacting Genes		12 interacting genes: BORCS6 EDARADD FBXW7 FDFT1 H3C1 H4C1 LPP RAD18 UBE2D1 UBE2N UBE2V2 YWHAG	30 interacting genes: ARRDC3 DAZAP2 DZIP3 GOLGA2 H2AC4 MAGEA4 MAP3K1 MAPK8 MLKL ORC2 PCGF6 PCNA PDCD5 POLK RAD51 RFC2 SHPRH SIVA1 TAX1BP1 TP53BP1 TRIM23 TRIM8 TSG101 UBC UBE2A UBE2B UBE2D2 UBE2I USP2 USP7
Entrez ID		257218	56852
HPRD ID		10476	09242
Ensembl ID		ENSG00000146414	ENSG00000070950
Uniprot IDs		B3KX98 Q149N8	Q9NS91
PDB IDs		2M85 4QN1	2MRE 2MRF 2Y43 2YBF 5VF0 8IR2 8IR4 9BD3
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Polyubiquitination Positive Regulation Of Post-translational Protein Modification Positive Regulation Of Protein Polyubiquitination Positive Regulation Of Protein Ubiquitination Protein Ubiquitination Postreplication Repair UBC13-MMS2 Complex Ubiquitin Conjugating Enzyme Complex Protein Modification By Small Protein Conjugation Regulation Of Protein Ubiquitination Post-translational Protein Modification TORC1 Signaling Negative Regulation Of TORC1 Signaling Positive Regulation Of Protein K63-linked Ubiquitination Ubiquitin-protein Transferase Activator Activity Regulation Of Post-translational Protein Modification TOR Signaling Protein Polyubiquitination Negative Regulation Of TOR Signaling Regulation Of TORC1 Signaling Regulation Of Protein K63-linked Ubiquitination Regulation Of Protein Modification Process Positive Regulation Of Protein Modification Process Protein-containing Complex Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process DNA Double-strand Break Processing Positive Regulation Of Protein Metabolic Process Regulation Of TOR Signaling Ubiquitin Conjugating Enzyme Activity Proteasomal Protein Catabolic Process DNA Repair Protein Modification Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Squalene Synthase [NAD(P)H] Activity Protein Catabolic Process Cellular Response To Nutrient Levels Protein Monoubiquitination Rad6-Rad18 Complex SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Chromosome Ubiquitin Protein Ligase Binding Protein K63-linked Ubiquitination DNA Metabolic Process Error-free Postreplication DNA Repair Negative Regulation Of Intracellular Signal Transduction Chromosome Organization Structural Constituent Of Chromatin DNA Damage Response	Post-translational Protein Modification Protein Modification By Small Protein Conjugation DNA Repair Protein Modification Process DNA Metabolic Process Protein Ubiquitination Macromolecule Metabolic Process Postreplication Repair Protein Polyubiquitination DNA Damage Response Response To Radiation Ubiquitin Protein Ligase Binding Nucleus Nuclear Body Ubiquitin-protein Transferase Activity Protein Metabolic Process Response To UV Replication Fork Response To Light Stimulus Ubiquitin Conjugating Enzyme Activity HULC Complex Protein K48-linked Ubiquitination Regulation Of Autophagy PML Body Nucleoplasm Chromatin Organization ATP Binding Nucleotide Binding Regulation Of Metabolic Process Transferase Activity Negative Regulation Of Metabolic Process Positive Regulation Of DNA-directed DNA Polymerase Activity DNA Replication Regulation Of DNA Metabolic Process Damaged DNA Binding Cellular Response To Radiation Cellular Response To Stress Positive Regulation Of Autophagy Chromosome, Telomeric Region P53 Binding Ubiquitin Protein Ligase Activity Response To Stress Nucleic Acid Metabolic Process Regulation Of Macromolecule Metabolic Process Modification-dependent Protein Catabolic Process Single-stranded DNA Helicase Activity Ubiquitin-like Protein Transferase Activity Regulation Of Nucleobase-containing Compound Metabolic Process Enzyme Binding DNA Polymerase Binding
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