SHPRH and RAD18

Number of citations of the paper that reports this interaction (PMID 25023518)
1

Data Source:
BioGRID (pull down)

		SHPRH	RAD18
Gene Name		SNF2 histone linker PHD RING helicase, E3 ubiquitin protein ligase	RAD18 E3 ubiquitin protein ligase
Image
Gene Ontology Annotations	Cellular Component	Nucleosome Nucleus	Chromatin XY Body Nucleus Replication Fork
	Molecular Function	DNA Binding Helicase Activity Ubiquitin-protein Transferase Activity ATP Binding Zinc Ion Binding Ligase Activity	Y-form DNA Binding Damaged DNA Binding Protein Binding Zinc Ion Binding Ligase Activity Polyubiquitin Binding Ubiquitin Protein Ligase Binding
	Biological Process	Protein Polyubiquitination DNA Repair Nucleosome Assembly	DNA Repair Spermatogenesis Response To UV Protein Ubiquitination Negative Regulation Of DNA Recombination
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		10 interactors: C17orf59 EDARADD FBXW7 FDFT1 LPP PCNA RAD18 UBE2N UBE2V2 YWHAG	21 interactors: DZIP3 MAPK8 MLKL NBN PCGF6 PCNA POLK RAD51 RFC2 SHPRH SIVA1 TAX1BP1 TP53BP1 TRIM23 TRIM8 TSG101 UBC UBE2A UBE2B UBE2I USP2
Entrez ID		257218	56852
HPRD ID		10476	09242
Ensembl ID		ENSG00000146414	ENSG00000070950
Uniprot IDs		B3KX98 K4DI94 Q149N8	Q9NS91
PDB IDs		2M85	2Y43 2YBF
Enriched GO Terms of Interacting Partners?		Postreplication Repair DNA Double-strand Break Processing Cellular Response To DNA Damage Stimulus Positive Regulation Of DNA Metabolic Process Protein Ubiquitination DNA Repair Protein Modification By Small Protein Conjugation Protein K63-linked Ubiquitination DNA Catabolic Process, Exonucleolytic Positive Regulation Of DNA Repair Cellular Response To Stress Regulation Of DNA Repair Positive Regulation Of Response To DNA Damage Stimulus Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Positive Regulation Of Deoxyribonuclease Activity Negative Regulation Of SREBP Signaling Pathway DNA Metabolic Process Regulation Of Ubiquitin-protein Transferase Activity Negative Regulation Of DNA Metabolic Process Negative Regulation Of Triglyceride Biosynthetic Process Leading Strand Elongation Regulation Of Response To DNA Damage Stimulus Regulation Of DNA Replication Response To UV Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Farnesyl Diphosphate Metabolic Process Positive Regulation Of Protein Ubiquitination DNA Catabolic Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Double-strand Break Repair Positive Regulation Of Cellular Protein Catabolic Process Regulation Of Histone Ubiquitination Negative Regulation Of Hepatocyte Proliferation Trachea Gland Development Protein Polyubiquitination Negative Regulation Of DNA Endoreduplication Positive Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Protein Ubiquitination Cellular Response To Stimulus Positive Regulation Of Oxidative Stress-induced Cell Death Positive Regulation Of Protein Catabolic Process Cellular Macromolecule Catabolic Process DNA Recombination Regulation Of Neuron Apoptotic Process Regulation Of DNA Endoreduplication Mitotic Cell Cycle Phase Transition	DNA Repair Cellular Response To DNA Damage Stimulus DNA Metabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cellular Response To Stress Protein Ubiquitination Protein Modification By Small Protein Conjugation DNA Recombination Protein Polyubiquitination Nucleotide-excision Repair, DNA Gap Filling Response To Stress Postreplication Repair Cell Cycle Cell Cycle Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Mitotic Recombination Proteasomal Protein Catabolic Process Cellular Protein Modification Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Regulation Of Nitrogen Compound Metabolic Process Cellular Metabolic Process Protein Catabolic Process Chromosome Organization Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of RNA Biosynthetic Process Response To Radiation Viral Protein Processing Telomere Maintenance Double-strand Break Repair Via Homologous Recombination Recombinational Repair Regulation Of Transcription, DNA-templated Cellular Macromolecule Catabolic Process Regulation Of Nucleic Acid-templated Transcription Cellular Protein Metabolic Process Regulation Of RNA Biosynthetic Process Nucleotide-excision Repair Histone H2A Ubiquitination Negative Regulation Of Gene Expression DNA Replication Regulation Of RNA Metabolic Process Viral Process Negative Regulation Of Biosynthetic Process Response To Stimulus DNA-dependent DNA Replication Telomere Maintenance Via Semi-conservative Replication Programmed Cell Death Regulation Of Metabolic Process
Tagcloud ?			break camptothecin chemotherapeutic collaboratively conjugating doi dsb dsbs dt40 hypersensitivity joining ku70 ligases nhej nonhomologous olaparib onc operate poison polymerization promotion publication rad51 rays recombinase repaired rnf8 topoisomerase ubc13
Tagcloud (Difference) ?			break camptothecin chemotherapeutic collaboratively conjugating doi dsb dsbs dt40 hypersensitivity joining ku70 ligases nhej nonhomologous olaparib onc operate poison polymerization promotion publication rad51 rays recombinase repaired rnf8 topoisomerase ubc13
Tagcloud (Intersection) ?