RAD18 and POLK

Number of citations of the paper that reports this interaction (PubMedID 21396873)
39

Data Source:
BioGRID (affinity chromatography technology, pull down)

		RAD18	POLK
Description		RAD18 E3 ubiquitin protein ligase	DNA polymerase kappa
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Replication Fork Chromosome Cytoplasm Centrosome Cytoskeleton Nuclear Body Site Of Double-strand Break Nuclear Inclusion Body Rad6-Rad18 Complex	Nucleus Nucleoplasm Nuclear Body Site Of DNA Damage
	Molecular Function	Y-form DNA Binding DNA Binding Damaged DNA Binding Single-stranded DNA Binding Protein Binding Zinc Ion Binding Transferase Activity Polyubiquitin Modification-dependent Protein Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Protein-containing Complex Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	DNA Binding Damaged DNA Binding DNA-directed DNA Polymerase Activity Zinc Ion Binding Transferase Activity Nucleotidyltransferase Activity DNA Polymerase Activity Metal Ion Binding
	Biological Process	DNA Repair Postreplication Repair Protein Monoubiquitination DNA Damage Response Protein Ubiquitination Protein Autoubiquitination Positive Regulation Of Chromosome Segregation	DNA Replication DNA Repair Nucleotide-excision Repair, DNA Gap Filling DNA Damage Response Cellular Response To UV Error-prone Translesion Synthesis DNA Biosynthetic Process
Pathways		Recognition of DNA damage by PCNA-containing replication complex E3 ubiquitin ligases ubiquitinate target proteins	Translesion synthesis by POLK Termination of translesion DNA synthesis HDR through Homologous Recombination (HRR) Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER
Drugs			1,2,3-TRIHYDROXY-1,2,3,4-TETRAHYDROBENZO[A]PYRENE 1-[2-DEOXYRIBOFURANOSYL]-2,4-DIFLUORO-5-METHYL-BENZENE-5'MONOPHOSPHATE 2'-deoxy-N-(naphthalen-1-ylmethyl)guanosine 5'-(dihydrogen phosphate)
Diseases
GWAS		Chronotype ( 30696823) Clopidogrel active metabolite levels ( 28207573) Metabolite levels ( 23823483) Morning person ( 30696823) Sleep duration ( 30531941) Transverse temporal cortex volume ( 31530798) Triglyceride levels ( 34074324)	Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634)
Interacting Genes		30 interacting genes: ARRDC3 DAZAP2 DZIP3 GOLGA2 H2AC4 MAGEA4 MAP3K1 MAPK8 MLKL ORC2 PCGF6 PCNA PDCD5 POLK RAD51 RFC2 SHPRH SIVA1 TAX1BP1 TP53BP1 TRIM23 TRIM8 TSG101 UBC UBE2A UBE2B UBE2D2 UBE2I USP2 USP7	5 interacting genes: PCNA RAD18 REV1 TRAIP WRN
Entrez ID		56852	51426
HPRD ID		09242	09291
Ensembl ID		ENSG00000070950	ENSG00000122008
Uniprot IDs		Q9NS91	Q9UBT6
PDB IDs		2MRE 2MRF 2Y43 2YBF 5VF0 8IR2 8IR4 9BD3	1T94 2LSI 2OH2 2W7O 2W7P 3IN5 3PZP 4BA9 4GK5 4U6P 4U7C 5T14 5W2A 5W2C 6BRX 6BS1 6CST 7NV0 7NV1
Enriched GO Terms of Interacting Partners?		Post-translational Protein Modification Protein Modification By Small Protein Conjugation DNA Repair Protein Modification Process DNA Metabolic Process Protein Ubiquitination Macromolecule Metabolic Process Postreplication Repair Protein Polyubiquitination DNA Damage Response Response To Radiation Ubiquitin Protein Ligase Binding Nucleus Nuclear Body Ubiquitin-protein Transferase Activity Protein Metabolic Process Response To UV Replication Fork Response To Light Stimulus Ubiquitin Conjugating Enzyme Activity HULC Complex Protein K48-linked Ubiquitination Regulation Of Autophagy PML Body Nucleoplasm Chromatin Organization ATP Binding Nucleotide Binding Regulation Of Metabolic Process Transferase Activity Negative Regulation Of Metabolic Process Positive Regulation Of DNA-directed DNA Polymerase Activity DNA Replication Regulation Of DNA Metabolic Process Damaged DNA Binding Cellular Response To Radiation Cellular Response To Stress Positive Regulation Of Autophagy Chromosome, Telomeric Region P53 Binding Ubiquitin Protein Ligase Activity Response To Stress Nucleic Acid Metabolic Process Regulation Of Macromolecule Metabolic Process Modification-dependent Protein Catabolic Process Single-stranded DNA Helicase Activity Ubiquitin-like Protein Transferase Activity Regulation Of Nucleobase-containing Compound Metabolic Process Enzyme Binding DNA Polymerase Binding	Replication Fork DNA Repair Replication Fork Processing DNA Metabolic Process DNA Synthesis Involved In DNA Repair Postreplication Repair DNA Damage Response Y-form DNA Binding Damaged DNA Binding DNA Biosynthetic Process MutLalpha Complex Binding Telomere Maintenance Via Semi-conservative Replication Cellular Response To Stress DNA Replication Response To UV Translesion Synthesis Nucleic Acid Metabolic Process Mismatch Repair Response To Light Stimulus Nucleobase-containing Compound Metabolic Process Protein-containing Complex Binding Response To Radiation Response To Stress PCNA Complex Replisome Positive Regulation Of Strand Invasion 3'-flap-structured DNA Binding Deoxycytidyl Transferase Activity Rad6-Rad18 Complex Telomere Maintenance PCNA-p21 Complex DNA Polymerase Processivity Factor Activity Centrosome Telomere Organization Purine-specific Mismatch Base Pair DNA N-glycosylase Activity Forked DNA-dependent Helicase Activity Chromosome Nucleoplasm Mitotic Telomere Maintenance Via Semi-conservative Replication Dinucleotide Insertion Or Deletion Binding 8-hydroxy-2'-deoxyguanosine DNA Binding Telomeric G-quadruplex DNA Binding Cellular Response To Radiation DNA Binding Chromosome, Telomeric Region Positive Regulation Of Deoxyribonuclease Activity Leading Strand Elongation Telomeric D-loop Binding Catalytic Activity, Acting On DNA Nucleobase-containing Compound Biosynthetic Process
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