RAD18 and POLK

Number of citations of the paper that reports this interaction (PMID 21396873)
21

Data Source:
BioGRID (affinity chromatography technology, pull down)

		RAD18	POLK
Gene Name		RAD18 E3 ubiquitin protein ligase	polymerase (DNA directed) kappa
Image
Gene Ontology Annotations	Cellular Component	Chromatin XY Body Nucleus Replication Fork	Nucleoplasm
	Molecular Function	Y-form DNA Binding Damaged DNA Binding Protein Binding Zinc Ion Binding Ligase Activity Polyubiquitin Binding Ubiquitin Protein Ligase Binding	Damaged DNA Binding DNA-directed DNA Polymerase Activity Metal Ion Binding
	Biological Process	DNA Repair Spermatogenesis Response To UV Protein Ubiquitination Negative Regulation Of DNA Recombination	DNA Replication DNA Repair Nucleotide-excision Repair, DNA Gap Filling DNA Biosynthetic Process
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		21 interactors: DZIP3 MAPK8 MLKL NBN PCGF6 PCNA POLK RAD51 RFC2 SHPRH SIVA1 TAX1BP1 TP53BP1 TRIM23 TRIM8 TSG101 UBC UBE2A UBE2B UBE2I USP2	3 interactors: RAD18 REV1 TRAIP
Entrez ID		56852	51426
HPRD ID		09242	09291
Ensembl ID		ENSG00000070950
Uniprot IDs		Q9NS91	Q9UBT6
PDB IDs		2Y43 2YBF	1T94 2LSI 2OH2 2W7O 2W7P 3IN5 3PZP 4BA9 4GK5
Enriched GO Terms of Interacting Partners?		DNA Repair Cellular Response To DNA Damage Stimulus DNA Metabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cellular Response To Stress Protein Ubiquitination Protein Modification By Small Protein Conjugation DNA Recombination Protein Polyubiquitination Nucleotide-excision Repair, DNA Gap Filling Response To Stress Postreplication Repair Cell Cycle Cell Cycle Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Mitotic Recombination Proteasomal Protein Catabolic Process Cellular Protein Modification Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Regulation Of Nitrogen Compound Metabolic Process Cellular Metabolic Process Protein Catabolic Process Chromosome Organization Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of RNA Biosynthetic Process Response To Radiation Viral Protein Processing Telomere Maintenance Double-strand Break Repair Via Homologous Recombination Recombinational Repair Regulation Of Transcription, DNA-templated Cellular Macromolecule Catabolic Process Regulation Of Nucleic Acid-templated Transcription Cellular Protein Metabolic Process Regulation Of RNA Biosynthetic Process Nucleotide-excision Repair Histone H2A Ubiquitination Negative Regulation Of Gene Expression DNA Replication Regulation Of RNA Metabolic Process Viral Process Negative Regulation Of Biosynthetic Process Response To Stimulus DNA-dependent DNA Replication Telomere Maintenance Via Semi-conservative Replication Programmed Cell Death Regulation Of Metabolic Process	Response To UV Error-prone Translesion Synthesis Response To Light Stimulus Response To Radiation Translesion Synthesis Protein Ubiquitination DNA Repair Protein Modification By Small Protein Conjugation Negative Regulation Of DNA Recombination Postreplication Repair Cellular Response To DNA Damage Stimulus DNA Metabolic Process Response To Abiotic Stimulus Regulation Of DNA Recombination
Tagcloud ?		break camptothecin chemotherapeutic collaboratively conjugating doi dsb dsbs dt40 hypersensitivity joining ku70 ligases nhej nonhomologous olaparib onc operate poison polymerization promotion publication rad51 rays recombinase repaired rnf8 topoisomerase ubc13	affordable brought collaboration collaborative community contributed convened coordinated county department drew emphasized engaged engagement forums goals meaningful mid organizations orientation priorities rural serving sharply surveys top ultimately wisconsin workgroups
Tagcloud (Difference) ?		break camptothecin chemotherapeutic collaboratively conjugating doi dsb dsbs dt40 hypersensitivity joining ku70 ligases nhej nonhomologous olaparib onc operate poison polymerization promotion publication rad51 rays recombinase repaired rnf8 topoisomerase ubc13	affordable brought collaboration collaborative community contributed convened coordinated county department drew emphasized engaged engagement forums goals meaningful mid organizations orientation priorities rural serving sharply surveys top ultimately wisconsin workgroups
Tagcloud (Intersection) ?