SHPRH and BORCS6

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		SHPRH	BORCS6
Description		SNF2 histone linker PHD RING helicase	BLOC-1 related complex subunit 6
Image			No pdb structure
GO Annotations	Cellular Component	Nucleosome Nucleus Nucleoplasm	Lysosome Lysosomal Membrane Membrane Cytoplasmic Side Of Lysosomal Membrane BORC Complex
	Molecular Function	Nucleotide Binding DNA Binding Helicase Activity Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Zinc Ion Binding Transferase Activity Hydrolase Activity Ubiquitin Protein Ligase Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Protein Binding Identical Protein Binding
	Biological Process	Protein Polyubiquitination DNA Repair Nucleosome Assembly DNA Damage Response Protein Ubiquitination	Lysosome Localization Regulation Of Endosome Size Regulation Of Lysosome Size Organelle Transport Along Microtubule
Pathways		E3 ubiquitin ligases ubiquitinate target proteins
Drugs
Diseases
GWAS
Interacting Genes		12 interacting genes: BORCS6 EDARADD FBXW7 FDFT1 H3C1 H4C1 LPP RAD18 UBE2D1 UBE2N UBE2V2 YWHAG	31 interacting genes: ABI2 AIRIM BEX2 C19orf25 C1orf216 DRC4 EPS8 EXOC8 EXOSC5 FAM161B FAM9C FBXO44 FCHSD2 HAUS1 HGS KANK2 LNX1 MED21 MOS NDEL1 NTAQ1 OSTF1 PKNOX1 PLA2G4A RCOR3 RIBC1 SHPRH SPG21 TACC2 USHBP1 ZNF655
Entrez ID		257218	54785
HPRD ID		10476	13368
Ensembl ID		ENSG00000146414	ENSG00000196544
Uniprot IDs		B3KX98 Q149N8	Q96GS4
PDB IDs		2M85 4QN1
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Polyubiquitination Positive Regulation Of Post-translational Protein Modification Positive Regulation Of Protein Polyubiquitination Positive Regulation Of Protein Ubiquitination Protein Ubiquitination Postreplication Repair UBC13-MMS2 Complex Ubiquitin Conjugating Enzyme Complex Protein Modification By Small Protein Conjugation Regulation Of Protein Ubiquitination Post-translational Protein Modification TORC1 Signaling Negative Regulation Of TORC1 Signaling Positive Regulation Of Protein K63-linked Ubiquitination Ubiquitin-protein Transferase Activator Activity Regulation Of Post-translational Protein Modification TOR Signaling Protein Polyubiquitination Negative Regulation Of TOR Signaling Regulation Of TORC1 Signaling Regulation Of Protein K63-linked Ubiquitination Regulation Of Protein Modification Process Positive Regulation Of Protein Modification Process Protein-containing Complex Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process DNA Double-strand Break Processing Positive Regulation Of Protein Metabolic Process Regulation Of TOR Signaling Ubiquitin Conjugating Enzyme Activity Proteasomal Protein Catabolic Process DNA Repair Protein Modification Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Squalene Synthase [NAD(P)H] Activity Protein Catabolic Process Cellular Response To Nutrient Levels Protein Monoubiquitination Rad6-Rad18 Complex SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Chromosome Ubiquitin Protein Ligase Binding Protein K63-linked Ubiquitination DNA Metabolic Process Error-free Postreplication DNA Repair Negative Regulation Of Intracellular Signal Transduction Chromosome Organization Structural Constituent Of Chromatin DNA Damage Response
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