RAD18 and PDCD5

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		RAD18	PDCD5
Description		RAD18 E3 ubiquitin protein ligase	programmed cell death 5
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Replication Fork Chromosome Cytoplasm Centrosome Cytoskeleton Nuclear Body Site Of Double-strand Break Nuclear Inclusion Body Rad6-Rad18 Complex	Nucleus Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	Y-form DNA Binding DNA Binding Damaged DNA Binding Single-stranded DNA Binding Protein Binding Zinc Ion Binding Transferase Activity Polyubiquitin Modification-dependent Protein Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Protein-containing Complex Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	DNA Binding Protein Binding Heparin Binding Acetyltransferase Activator Activity Beta-tubulin Binding
	Biological Process	DNA Repair Postreplication Repair Protein Monoubiquitination DNA Damage Response Protein Ubiquitination Protein Autoubiquitination Positive Regulation Of Chromosome Segregation	Apoptotic Process Positive Regulation Of Gene Expression Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Cellular Response To Transforming Growth Factor Beta Stimulus Negative Regulation Of Protein Folding
Pathways		Recognition of DNA damage by PCNA-containing replication complex E3 ubiquitin ligases ubiquitinate target proteins
Drugs
Diseases
GWAS		Chronotype ( 30696823) Clopidogrel active metabolite levels ( 28207573) Metabolite levels ( 23823483) Morning person ( 30696823) Sleep duration ( 30531941) Transverse temporal cortex volume ( 31530798) Triglyceride levels ( 34074324)	Glycated hemoglobin levels ( 34059833) Immature fraction of reticulocytes ( 32888494) Major depressive disorder ( 23377640) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 27863252 32888494) Mean platelet volume ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Platelet count ( 32888494) Red cell distribution width ( 27863252 32888494) Systemic lupus erythematosus ( 33272962)
Interacting Genes		30 interacting genes: ARRDC3 DAZAP2 DZIP3 GOLGA2 H2AC4 MAGEA4 MAP3K1 MAPK8 MLKL ORC2 PCGF6 PCNA PDCD5 POLK RAD51 RFC2 SHPRH SIVA1 TAX1BP1 TP53BP1 TRIM23 TRIM8 TSG101 UBC UBE2A UBE2B UBE2D2 UBE2I USP2 USP7	16 interacting genes: ACP5 CDC42 CEBPA CEP126 EEF1G KAT5 KDM1A LRIF1 NUDT3 OTUD5 PICK1 RAD18 TRIM35 UBE2D3 UTP14A VHL
Entrez ID		56852	9141
HPRD ID		09242	06843
Ensembl ID		ENSG00000070950	ENSG00000105185
Uniprot IDs		Q9NS91	O14737
PDB IDs		2MRE 2MRF 2Y43 2YBF 5VF0 8IR2 8IR4 9BD3	1YYB 2CRU 2K6B
Enriched GO Terms of Interacting Partners?		Post-translational Protein Modification Protein Modification By Small Protein Conjugation DNA Repair Protein Modification Process DNA Metabolic Process Protein Ubiquitination Macromolecule Metabolic Process Postreplication Repair Protein Polyubiquitination DNA Damage Response Response To Radiation Ubiquitin Protein Ligase Binding Nucleus Nuclear Body Ubiquitin-protein Transferase Activity Protein Metabolic Process Response To UV Replication Fork Response To Light Stimulus Ubiquitin Conjugating Enzyme Activity HULC Complex Protein K48-linked Ubiquitination Regulation Of Autophagy PML Body Nucleoplasm Chromatin Organization ATP Binding Nucleotide Binding Regulation Of Metabolic Process Transferase Activity Negative Regulation Of Metabolic Process Positive Regulation Of DNA-directed DNA Polymerase Activity DNA Replication Regulation Of DNA Metabolic Process Damaged DNA Binding Cellular Response To Radiation Cellular Response To Stress Positive Regulation Of Autophagy Chromosome, Telomeric Region P53 Binding Ubiquitin Protein Ligase Activity Response To Stress Nucleic Acid Metabolic Process Regulation Of Macromolecule Metabolic Process Modification-dependent Protein Catabolic Process Single-stranded DNA Helicase Activity Ubiquitin-like Protein Transferase Activity Regulation Of Nucleobase-containing Compound Metabolic Process Enzyme Binding DNA Polymerase Binding	Protein Modification Process DNA-binding Transcription Factor Binding Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Protein Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process Negative Regulation Of Superoxide Anion Generation Regulation Of Attachment Of Spindle Microtubules To Kinetochore Macrophage Differentiation Neuron Projection Organization Ubiquitin Protein Ligase Activity Dendritic Spine Organization Postsynapse Organization RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Gamma-glutamyl Carboxylase Activity Histone H2AK5 Acetyltransferase Activity DNA Repair-dependent Chromatin Remodeling Positive Regulation Of Chromosome Segregation Inositol Diphosphate Tetrakisphosphate Diphosphatase Activity Inositol Diphosphate Pentakisphosphate Diphosphatase Activity Diphosphoinositol Polyphosphate Catabolic Process Rad6-Rad18 Complex Post-translational Protein Modification Cellular Response To Glucose Starvation Negative Regulation Of Macromolecule Metabolic Process GBD Domain Binding Storage Vacuole Transcription Regulator Complex Negative Regulation Of Transcription By RNA Polymerase II Response To Vitamin B2 C/EBP Complex Vitamin Binding Negative Regulation Of Bone Development Protein Monoubiquitination Peptide Butyryltransferase Activity Peptide 2-hydroxyisobutyryltransferase Activity Peptide Crotonyltransferase Activity 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] Diphosphatase Activity Inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase Activity Inositol Phosphate Catabolic Process Inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate Diphosphatase Activity Telomeric Repeat-containing RNA Binding FAD-dependent H3K4me/H3K4me3 Demethylase Activity Positive Regulation Of Cell Cycle Process Protein Autoubiquitination Endothelin Receptor Signaling Pathway Involved In Heart Process Regulation Of Cell Cycle CHOP-C/EBP Complex Cellular Response To Stress
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