RAD18 and MLKL

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		RAD18	MLKL
Description		RAD18 E3 ubiquitin protein ligase	mixed lineage kinase domain like pseudokinase
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Replication Fork Chromosome Cytoplasm Centrosome Cytoskeleton Nuclear Body Site Of Double-strand Break Nuclear Inclusion Body Rad6-Rad18 Complex	Nucleus Cytoplasm Cytosol Plasma Membrane Membrane Cell Junction
	Molecular Function	Y-form DNA Binding DNA Binding Damaged DNA Binding Single-stranded DNA Binding Protein Binding Zinc Ion Binding Transferase Activity Polyubiquitin Modification-dependent Protein Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Protein-containing Complex Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Identical Protein Binding Protein-containing Complex Binding
	Biological Process	DNA Repair Postreplication Repair Protein Monoubiquitination DNA Damage Response Protein Ubiquitination Protein Autoubiquitination Positive Regulation Of Chromosome Segregation	Cell Surface Receptor Signaling Pathway Programmed Cell Death Defense Response To Virus Protein Homotrimerization Necroptotic Process Necroptotic Signaling Pathway Execution Phase Of Necroptosis
Pathways		Recognition of DNA damage by PCNA-containing replication complex E3 ubiquitin ligases ubiquitinate target proteins	TRP channels RIPK1-mediated regulated necrosis Regulation of necroptotic cell death Microbial modulation of RIPK1-mediated regulated necrosis
Drugs
Diseases
GWAS		Chronotype ( 30696823) Clopidogrel active metabolite levels ( 28207573) Metabolite levels ( 23823483) Morning person ( 30696823) Sleep duration ( 30531941) Transverse temporal cortex volume ( 31530798) Triglyceride levels ( 34074324)	Heel bone mineral density x serum urate levels interaction ( 34046847) Testicular germ cell tumor ( 23666239)
Interacting Genes		30 interacting genes: ARRDC3 DAZAP2 DZIP3 GOLGA2 H2AC4 MAGEA4 MAP3K1 MAPK8 MLKL ORC2 PCGF6 PCNA PDCD5 POLK RAD51 RFC2 SHPRH SIVA1 TAX1BP1 TP53BP1 TRIM23 TRIM8 TSG101 UBC UBE2A UBE2B UBE2D2 UBE2I USP2 USP7	12 interacting genes: ANAPC11 CDK1 CEBPA CYLD ITCH NDUFB7 PSMB1 RAD18 S100A10 STAMBP THOC3 USP2
Entrez ID		56852	197259
HPRD ID		09242	08752
Ensembl ID		ENSG00000070950	ENSG00000168404
Uniprot IDs		Q9NS91	Q8NB16
PDB IDs		2MRE 2MRF 2Y43 2YBF 5VF0 8IR2 8IR4 9BD3	2MSV 4M67 4MWI 5KNJ 5KO1 6BWK 6D74 6LK5 6LK6 6O5Z 6UX8 6ZLE 6ZPR 6ZVO 6ZZ1 7JW7 7JXU 7MON 7NM2 7NM4 7NM5 8SLZ
Enriched GO Terms of Interacting Partners?		Post-translational Protein Modification Protein Modification By Small Protein Conjugation DNA Repair Protein Modification Process DNA Metabolic Process Protein Ubiquitination Macromolecule Metabolic Process Postreplication Repair Protein Polyubiquitination DNA Damage Response Response To Radiation Ubiquitin Protein Ligase Binding Nucleus Nuclear Body Ubiquitin-protein Transferase Activity Protein Metabolic Process Response To UV Replication Fork Response To Light Stimulus Ubiquitin Conjugating Enzyme Activity HULC Complex Protein K48-linked Ubiquitination Regulation Of Autophagy PML Body Nucleoplasm Chromatin Organization ATP Binding Nucleotide Binding Regulation Of Metabolic Process Transferase Activity Negative Regulation Of Metabolic Process Positive Regulation Of DNA-directed DNA Polymerase Activity DNA Replication Regulation Of DNA Metabolic Process Damaged DNA Binding Cellular Response To Radiation Cellular Response To Stress Positive Regulation Of Autophagy Chromosome, Telomeric Region P53 Binding Ubiquitin Protein Ligase Activity Response To Stress Nucleic Acid Metabolic Process Regulation Of Macromolecule Metabolic Process Modification-dependent Protein Catabolic Process Single-stranded DNA Helicase Activity Ubiquitin-like Protein Transferase Activity Regulation Of Nucleobase-containing Compound Metabolic Process Enzyme Binding DNA Polymerase Binding	Post-translational Protein Modification Protein Deubiquitination Protein Modification By Small Protein Removal Macromolecule Metabolic Process Protein Modification Process Nucleoplasm Regulation Of Cell Cycle K63-linked Deubiquitinase Activity Ubiquitin-ubiquitin Ligase Activity Positive Regulation Of Cell Cycle Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Protein Branched Polyubiquitination Positive Regulation Of Mitotic Cell Cycle Regulation Of Chromosome Segregation Proteolysis Protein K63-linked Deubiquitination Positive Regulation Of Chromosome Segregation Regulation Of Necroptotic Process Cyclin Binding Negative Regulation Of JNK Cascade Regulation Of Programmed Necrotic Cell Death Protein Metabolic Process Regulation Of Mitotic Cell Cycle Negative Regulation Of Type I Interferon Production Pronuclear Fusion RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Negative Regulation Of Interleukin-18-mediated Signaling Pathway Met1-linked Polyubiquitin Deubiquitinase Activity Rad6-Rad18 Complex Protein Monoubiquitination Positive Regulation Of Cell Cycle Process Centrosome Mitotic DNA-templated DNA Replication Cyclin B1-CDK1 Complex Cyclin A1-CDK1 Complex Cyclin A2-CDK1 Complex Response To Vitamin B2 C/EBP Complex Ripoptosome Assembly Ripoptosome Assembly Involved In Necroptotic Process AnxA2-p11 Complex Protein Autoubiquitination Mitotic DNA Replication DNA Synthesis Involved In Mitotic DNA Replication Cyclin-dependent Protein Kinase Activity CHOP-C/EBP Complex Protein Linear Deubiquitination Cysteine-type Deubiquitinase Activity Hippocampal Neuron Apoptotic Process Ubiquitin Protein Ligase Activity
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