SHPRH and EDARADD

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		SHPRH	EDARADD
Description		SNF2 histone linker PHD RING helicase	EDAR associated via death domain
Image			No pdb structure
GO Annotations	Cellular Component	Nucleosome Nucleus Nucleoplasm	Cytoplasm Cytosol
	Molecular Function	Nucleotide Binding DNA Binding Helicase Activity Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Zinc Ion Binding Transferase Activity Hydrolase Activity Ubiquitin Protein Ligase Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Protein Binding
	Biological Process	Protein Polyubiquitination DNA Repair Nucleosome Assembly DNA Damage Response Protein Ubiquitination	Signal Transduction Cell Differentiation
Pathways		E3 ubiquitin ligases ubiquitinate target proteins	TNFs bind their physiological receptors
Drugs
Diseases			Ectodermal dysplasia, including: Ectodermal dysplasia, anhidrotic; Ectodermal dysplasia, hypohidrotic
GWAS			Autoimmune thyroid disease ( 32581359) Urate levels (BMI interaction) ( 25811787)
Interacting Genes		12 interacting genes: BORCS6 EDARADD FBXW7 FDFT1 H3C1 H4C1 LPP RAD18 UBE2D1 UBE2N UBE2V2 YWHAG	11 interacting genes: EDAR LINC01554 NTAQ1 RNF111 SDCBP SHPRH SUMO1 SUMO1P1 TRAF2 TRAF6 UBE2I
Entrez ID		257218	128178
HPRD ID		10476	05965
Ensembl ID		ENSG00000146414	ENSG00000186197
Uniprot IDs		B3KX98 Q149N8	A0A1B0GV26 Q8WWZ3
PDB IDs		2M85 4QN1
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Polyubiquitination Positive Regulation Of Post-translational Protein Modification Positive Regulation Of Protein Polyubiquitination Positive Regulation Of Protein Ubiquitination Protein Ubiquitination Postreplication Repair UBC13-MMS2 Complex Ubiquitin Conjugating Enzyme Complex Protein Modification By Small Protein Conjugation Regulation Of Protein Ubiquitination Post-translational Protein Modification TORC1 Signaling Negative Regulation Of TORC1 Signaling Positive Regulation Of Protein K63-linked Ubiquitination Ubiquitin-protein Transferase Activator Activity Regulation Of Post-translational Protein Modification TOR Signaling Protein Polyubiquitination Negative Regulation Of TOR Signaling Regulation Of TORC1 Signaling Regulation Of Protein K63-linked Ubiquitination Regulation Of Protein Modification Process Positive Regulation Of Protein Modification Process Protein-containing Complex Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process DNA Double-strand Break Processing Positive Regulation Of Protein Metabolic Process Regulation Of TOR Signaling Ubiquitin Conjugating Enzyme Activity Proteasomal Protein Catabolic Process DNA Repair Protein Modification Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Squalene Synthase [NAD(P)H] Activity Protein Catabolic Process Cellular Response To Nutrient Levels Protein Monoubiquitination Rad6-Rad18 Complex SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Chromosome Ubiquitin Protein Ligase Binding Protein K63-linked Ubiquitination DNA Metabolic Process Error-free Postreplication DNA Repair Negative Regulation Of Intracellular Signal Transduction Chromosome Organization Structural Constituent Of Chromatin DNA Damage Response	Protein Modification By Small Protein Conjugation Post-translational Protein Modification Transcription Factor Binding PML Body Protein Modification Process Regulation Of JNK Cascade Small Protein Activating Enzyme Binding Protein Sumoylation PML Body Organization Positive Regulation Of Canonical NF-kappaB Signal Transduction CD40 Signaling Pathway Interleukin-17-mediated Signaling Pathway Protein Polyubiquitination CD40 Receptor Complex Positive Regulation Of JUN Kinase Activity Positive Regulation Of JNK Cascade Regulation Of Canonical NF-kappaB Signal Transduction Protein Tag Activity Ubiquitin Protein Ligase Activity Nuclear Body Organization Protein Metabolic Process Enzyme Binding Ubiquitin-like Protein Ligase Binding Positive Regulation Of MAPK Cascade Positive Regulation Of T Cell Cytokine Production Presynaptic Cytosol Postsynaptic Cytosol Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of DNA-binding Transcription Factor Activity Tumor Necrosis Factor Receptor Binding Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Signal Transduction Positive Regulation Of MAP Kinase Activity Positive Regulation Of Interleukin-2 Production Regulation Of T Cell Cytokine Production Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Intracellular Signal Transduction Protein Ubiquitination Positive Regulation Of Phosphorylation Ubiquitin-protein Transferase Activity Interleukin-5 Receptor Complex Regulation Of MAPK Cascade TORC2 Complex Disassembly Positive Regulation Of Protein Serine/threonine Kinase Activity SUMO Conjugating Enzyme Activity Protein-N-terminal Glutamine Amidohydrolase Activity Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Interleukin-2 Production Regulation Of MAP Kinase Activity
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