RAD18 and TRIM8

Number of citations of the paper that reports this interaction (PMID 22493164)
2

Data Source:
BioGRID (two hybrid)

		RAD18	TRIM8
Gene Name		RAD18 E3 ubiquitin protein ligase	tripartite motif containing 8
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Chromatin XY Body Nucleus Replication Fork	Nucleoplasm Cytoplasm Cytosol PML Body Intracellular Membrane-bounded Organelle
	Molecular Function	Y-form DNA Binding Damaged DNA Binding Protein Binding Zinc Ion Binding Ligase Activity Polyubiquitin Binding Ubiquitin Protein Ligase Binding	Zinc Ion Binding Ligase Activity Identical Protein Binding Protein Homodimerization Activity
	Biological Process	DNA Repair Spermatogenesis Response To UV Protein Ubiquitination Negative Regulation Of DNA Recombination	Protein Ubiquitination Cytokine-mediated Signaling Pathway Negative Regulation Of Viral Transcription Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Negative Regulation Of Viral Entry Into Host Cell Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Interferon-gamma-mediated Signaling Pathway Negative Regulation Of Viral Release From Host Cell
Pathways			Interferon gamma signaling Interferon Signaling Cytokine Signaling in Immune system
Drugs
Diseases
GWAS			Prostate cancer ( 23535732)
Protein-Protein Interactions		21 interactors: DZIP3 MAPK8 MLKL NBN PCGF6 PCNA POLK RAD51 RFC2 SHPRH SIVA1 TAX1BP1 TP53BP1 TRIM23 TRIM8 TSG101 UBC UBE2A UBE2B UBE2I USP2	45 interactors: BRAP CBL CCNH ITSN1 MAP3K7 MKRN3 MSL2 OTUB2 PCGF5 RAD18 RC3H2 RCHY1 RNF111 RNF113A RNF138 RNF141 RNF181 RNF41 RNF7 SIAH1 SOCS1 TNFAIP3 TRAF5 TRIM15 TRIM2 TRIM21 TRIM24 TRIM25 TRIM39 TRIM43 TRIM47 TRIM9 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2L6 UBE2V1 UBE2W UHRF2 USP2 USP21 USP39 USP7 XIAP
Entrez ID		56852	81603
HPRD ID		09242	06934
Ensembl ID		ENSG00000070950	ENSG00000171206
Uniprot IDs		Q9NS91	Q9BZR9
PDB IDs		2Y43 2YBF
Enriched GO Terms of Interacting Partners?		DNA Repair Cellular Response To DNA Damage Stimulus DNA Metabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cellular Response To Stress Protein Ubiquitination Protein Modification By Small Protein Conjugation DNA Recombination Protein Polyubiquitination Nucleotide-excision Repair, DNA Gap Filling Response To Stress Postreplication Repair Cell Cycle Cell Cycle Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Mitotic Recombination Proteasomal Protein Catabolic Process Cellular Protein Modification Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Regulation Of Nitrogen Compound Metabolic Process Cellular Metabolic Process Protein Catabolic Process Chromosome Organization Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of RNA Biosynthetic Process Response To Radiation Viral Protein Processing Telomere Maintenance Double-strand Break Repair Via Homologous Recombination Recombinational Repair Regulation Of Transcription, DNA-templated Cellular Macromolecule Catabolic Process Regulation Of Nucleic Acid-templated Transcription Cellular Protein Metabolic Process Regulation Of RNA Biosynthetic Process Nucleotide-excision Repair Histone H2A Ubiquitination Negative Regulation Of Gene Expression DNA Replication Regulation Of RNA Metabolic Process Viral Process Negative Regulation Of Biosynthetic Process Response To Stimulus DNA-dependent DNA Replication Telomere Maintenance Via Semi-conservative Replication Programmed Cell Death Regulation Of Metabolic Process	Protein Ubiquitination Protein Modification By Small Protein Conjugation Cellular Protein Modification Process Cellular Protein Metabolic Process Protein Metabolic Process Protein Catabolic Process Protein Polyubiquitination Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Modification-dependent Protein Catabolic Process Cellular Macromolecule Catabolic Process Cellular Metabolic Process Ubiquitin-dependent Protein Catabolic Process Protein Autoubiquitination Proteolysis Proteasomal Protein Catabolic Process Catabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Protein K48-linked Ubiquitination Regulation Of Innate Immune Response Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Type I Interferon Production Metabolic Process Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Innate Immune Response Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Toll-like Receptor 4 Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of Innate Immune Response Positive Regulation Of Signal Transduction Protein Deubiquitination Negative Regulation Of Type I Interferon Production Immune Response Toll-like Receptor Signaling Pathway Regulation Of Protein Ubiquitination Regulation Of Signal Transduction Protein Modification By Small Protein Removal Regulation Of Metabolic Process Negative Regulation Of Viral Release From Host Cell Positive Regulation Of NF-kappaB Transcription Factor Activity Protein K48-linked Deubiquitination Regulation Of Gene Expression Protein K63-linked Deubiquitination Cellular Process Regulation Of Protein Catabolic Process Regulation Of Nitrogen Compound Metabolic Process Apoptotic Process TRIF-dependent Toll-like Receptor Signaling Pathway
Tagcloud ?		break camptothecin chemotherapeutic collaboratively conjugating doi dsb dsbs dt40 hypersensitivity joining ku70 ligases nhej nonhomologous olaparib onc operate poison polymerization promotion publication rad51 rays recombinase repaired rnf8 topoisomerase ubc13	aggressive ccrcc chemotherapeutic cytotoxic defective deficit define dramatically enhancer impairing impairs inactivated inactivation link mdm2 mechanistic modulator p53 rcc re regulators renders restoring stabilizes suppress treating tumours way wild
Tagcloud (Difference) ?		break camptothecin collaboratively conjugating doi dsb dsbs dt40 hypersensitivity joining ku70 ligases nhej nonhomologous olaparib onc operate poison polymerization promotion publication rad51 rays recombinase repaired rnf8 topoisomerase ubc13	aggressive ccrcc cytotoxic defective deficit define dramatically enhancer impairing impairs inactivated inactivation link mdm2 mechanistic modulator p53 rcc re regulators renders restoring stabilizes suppress treating tumours way wild
Tagcloud (Intersection) ?		chemotherapeutic