SHPRH and FDFT1

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		SHPRH	FDFT1
Gene Name		SNF2 histone linker PHD RING helicase, E3 ubiquitin protein ligase	farnesyl-diphosphate farnesyltransferase 1
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Gene Ontology Annotations	Cellular Component	Nucleosome Nucleus	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane
	Molecular Function	DNA Binding Helicase Activity Ubiquitin-protein Transferase Activity ATP Binding Zinc Ion Binding Ligase Activity	Farnesyl-diphosphate Farnesyltransferase Activity Oxidoreductase Activity Squalene Synthase Activity
	Biological Process	Protein Polyubiquitination DNA Repair Nucleosome Assembly	Steroid Biosynthetic Process Cholesterol Biosynthetic Process Isoprenoid Biosynthetic Process Cellular Lipid Metabolic Process Small Molecule Metabolic Process Farnesyl Diphosphate Metabolic Process Oxidation-reduction Process
Pathways			Regulation of cholesterol biosynthesis by SREBP (SREBF) PPARA activates gene expression Cholesterol biosynthesis Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Activation of gene expression by SREBF (SREBP) Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Drugs
Diseases
GWAS			Non-alcoholic fatty liver disease histology (lobular) ( 20708005) Non-alcoholic fatty liver disease histology (other) ( 20708005)
Protein-Protein Interactions		10 interactors: C17orf59 EDARADD FBXW7 FDFT1 LPP PCNA RAD18 UBE2N UBE2V2 YWHAG	6 interactors: ANXA5 ARL6IP1 FAM101A RUVBL2 SHPRH TMEM43
Entrez ID		257218	2222
HPRD ID		10476	01694
Ensembl ID		ENSG00000146414	ENSG00000079459
Uniprot IDs		B3KX98 K4DI94 Q149N8	B4DT56 B4DWP0 B7Z1J3 P37268 Q6IAX1
PDB IDs		2M85	1EZF 3ASX 3LEE 3Q2Z 3Q30 3V66 3VJ8 3VJ9 3VJA 3VJB 3VJC
Enriched GO Terms of Interacting Partners?		Postreplication Repair DNA Double-strand Break Processing Cellular Response To DNA Damage Stimulus Positive Regulation Of DNA Metabolic Process Protein Ubiquitination DNA Repair Protein Modification By Small Protein Conjugation Protein K63-linked Ubiquitination DNA Catabolic Process, Exonucleolytic Positive Regulation Of DNA Repair Cellular Response To Stress Regulation Of DNA Repair Positive Regulation Of Response To DNA Damage Stimulus Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Positive Regulation Of Deoxyribonuclease Activity Negative Regulation Of SREBP Signaling Pathway DNA Metabolic Process Regulation Of Ubiquitin-protein Transferase Activity Negative Regulation Of DNA Metabolic Process Negative Regulation Of Triglyceride Biosynthetic Process Leading Strand Elongation Regulation Of Response To DNA Damage Stimulus Regulation Of DNA Replication Response To UV Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Farnesyl Diphosphate Metabolic Process Positive Regulation Of Protein Ubiquitination DNA Catabolic Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Double-strand Break Repair Positive Regulation Of Cellular Protein Catabolic Process Regulation Of Histone Ubiquitination Negative Regulation Of Hepatocyte Proliferation Trachea Gland Development Protein Polyubiquitination Negative Regulation Of DNA Endoreduplication Positive Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Protein Ubiquitination Cellular Response To Stimulus Positive Regulation Of Oxidative Stress-induced Cell Death Positive Regulation Of Protein Catabolic Process Cellular Macromolecule Catabolic Process DNA Recombination Regulation Of Neuron Apoptotic Process Regulation Of DNA Endoreduplication Mitotic Cell Cycle Phase Transition	Negative Regulation Of Estrogen Receptor Binding Transcriptional Activation By Promoter-enhancer Looping Nuclear Membrane Organization Establishment Of Protein Localization To Chromatin DNA Conformation Change Negative Regulation Of Receptor Binding Protein Localization To Chromatin Histone H2A Acetylation
Tagcloud ?			abca1 biosynthesis brains cassette cholesterol debated extensively fdps genetically idi1 ldr lipids microarray mvd mvk notably nsdhl oligomeric oligomers plaques principal qpcr sc4mol steroid steroids toxic unexpected unresolved verified
Tagcloud (Difference) ?			abca1 biosynthesis brains cassette cholesterol debated extensively fdps genetically idi1 ldr lipids microarray mvd mvk notably nsdhl oligomeric oligomers plaques principal qpcr sc4mol steroid steroids toxic unexpected unresolved verified
Tagcloud (Intersection) ?