RAD18 and MAGEA4

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		RAD18	MAGEA4
Description		RAD18 E3 ubiquitin protein ligase	MAGE family member A4
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Replication Fork Chromosome Cytoplasm Centrosome Cytoskeleton Nuclear Body Site Of Double-strand Break Nuclear Inclusion Body Rad6-Rad18 Complex	Nucleus
	Molecular Function	Y-form DNA Binding DNA Binding Damaged DNA Binding Single-stranded DNA Binding Protein Binding Zinc Ion Binding Transferase Activity Polyubiquitin Modification-dependent Protein Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Protein-containing Complex Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Protein Binding Histone Deacetylase Binding
	Biological Process	DNA Repair Postreplication Repair Protein Monoubiquitination DNA Damage Response Protein Ubiquitination Protein Autoubiquitination Positive Regulation Of Chromosome Segregation	Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Apoptotic Process Positive Regulation Of Cell Cycle
Pathways		Recognition of DNA damage by PCNA-containing replication complex E3 ubiquitin ligases ubiquitinate target proteins
Drugs
Diseases
GWAS		Chronotype ( 30696823) Clopidogrel active metabolite levels ( 28207573) Metabolite levels ( 23823483) Morning person ( 30696823) Sleep duration ( 30531941) Transverse temporal cortex volume ( 31530798) Triglyceride levels ( 34074324)
Interacting Genes		30 interacting genes: ARRDC3 DAZAP2 DZIP3 GOLGA2 H2AC4 MAGEA4 MAP3K1 MAPK8 MLKL ORC2 PCGF6 PCNA PDCD5 POLK RAD51 RFC2 SHPRH SIVA1 TAX1BP1 TP53BP1 TRIM23 TRIM8 TSG101 UBC UBE2A UBE2B UBE2D2 UBE2I USP2 USP7	27 interacting genes: AMOT AMOTL2 APP ARNT2 BEX2 COX8A GTF3C1 HDDC3 HLA-A LDLRAP1 PICK1 POT1 PSMD10 PUDP RAD18 TEKT4 TIGD5 TK1 TRIM69 TSPYL1 TSPYL4 TXN2 UBXN6 UQCRB UVSSA WBP2 ZNF576
Entrez ID		56852	4103
HPRD ID		09242	02167
Ensembl ID		ENSG00000070950	ENSG00000147381
Uniprot IDs		Q9NS91	P43358
PDB IDs		2MRE 2MRF 2Y43 2YBF 5VF0 8IR2 8IR4 9BD3	1I4F 2WA0 6TRN 6TRO 7UOA 8ES8 8ES9 8FJA 9BD3
Enriched GO Terms of Interacting Partners?		Post-translational Protein Modification Protein Modification By Small Protein Conjugation DNA Repair Protein Modification Process DNA Metabolic Process Protein Ubiquitination Macromolecule Metabolic Process Postreplication Repair Protein Polyubiquitination DNA Damage Response Response To Radiation Ubiquitin Protein Ligase Binding Nucleus Nuclear Body Ubiquitin-protein Transferase Activity Protein Metabolic Process Response To UV Replication Fork Response To Light Stimulus Ubiquitin Conjugating Enzyme Activity HULC Complex Protein K48-linked Ubiquitination Regulation Of Autophagy PML Body Nucleoplasm Chromatin Organization ATP Binding Nucleotide Binding Regulation Of Metabolic Process Transferase Activity Negative Regulation Of Metabolic Process Positive Regulation Of DNA-directed DNA Polymerase Activity DNA Replication Regulation Of DNA Metabolic Process Damaged DNA Binding Cellular Response To Radiation Cellular Response To Stress Positive Regulation Of Autophagy Chromosome, Telomeric Region P53 Binding Ubiquitin Protein Ligase Activity Response To Stress Nucleic Acid Metabolic Process Regulation Of Macromolecule Metabolic Process Modification-dependent Protein Catabolic Process Single-stranded DNA Helicase Activity Ubiquitin-like Protein Transferase Activity Regulation Of Nucleobase-containing Compound Metabolic Process Enzyme Binding DNA Polymerase Binding	Establishment Of Cell Polarity Involved In Ameboidal Cell Migration
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