RAD18 and PCGF6

Number of citations of the paper that reports this interaction (PMID 22493164)
2

Data Source:
BioGRID (two hybrid)

		RAD18	PCGF6
Gene Name		RAD18 E3 ubiquitin protein ligase	polycomb group ring finger 6
Image
Gene Ontology Annotations	Cellular Component	Chromatin XY Body Nucleus Replication Fork	Nucleus PcG Protein Complex PRC1 Complex
	Molecular Function	Y-form DNA Binding Damaged DNA Binding Protein Binding Zinc Ion Binding Ligase Activity Polyubiquitin Binding Ubiquitin Protein Ligase Binding	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Zinc Ion Binding
	Biological Process	DNA Repair Spermatogenesis Response To UV Protein Ubiquitination Negative Regulation Of DNA Recombination	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Negative Regulation Of Transcription, DNA-templated
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		21 interactors: DZIP3 MAPK8 MLKL NBN PCGF6 PCNA POLK RAD51 RFC2 SHPRH SIVA1 TAX1BP1 TP53BP1 TRIM23 TRIM8 TSG101 UBC UBE2A UBE2B UBE2I USP2	16 interactors: BMI1 CBX6 CBX7 CBX8 CDK7 E2F6 HIST3H3 KDM5D PEX10 RAD18 RING1 RNF2 SS18L1 UBE2U USP2 USP21
Entrez ID		56852	84108
HPRD ID		09242	07427
Ensembl ID		ENSG00000070950	ENSG00000156374
Uniprot IDs		Q9NS91	Q9BYE7
PDB IDs		2Y43 2YBF	2DJB
Enriched GO Terms of Interacting Partners?		DNA Repair Cellular Response To DNA Damage Stimulus DNA Metabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cellular Response To Stress Protein Ubiquitination Protein Modification By Small Protein Conjugation DNA Recombination Protein Polyubiquitination Nucleotide-excision Repair, DNA Gap Filling Response To Stress Postreplication Repair Cell Cycle Cell Cycle Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Mitotic Recombination Proteasomal Protein Catabolic Process Cellular Protein Modification Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Regulation Of Nitrogen Compound Metabolic Process Cellular Metabolic Process Protein Catabolic Process Chromosome Organization Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of RNA Biosynthetic Process Response To Radiation Viral Protein Processing Telomere Maintenance Double-strand Break Repair Via Homologous Recombination Recombinational Repair Regulation Of Transcription, DNA-templated Cellular Macromolecule Catabolic Process Regulation Of Nucleic Acid-templated Transcription Cellular Protein Metabolic Process Regulation Of RNA Biosynthetic Process Nucleotide-excision Repair Histone H2A Ubiquitination Negative Regulation Of Gene Expression DNA Replication Regulation Of RNA Metabolic Process Viral Process Negative Regulation Of Biosynthetic Process Response To Stimulus DNA-dependent DNA Replication Telomere Maintenance Via Semi-conservative Replication Programmed Cell Death Regulation Of Metabolic Process	Chromatin Modification Chromosome Organization Chromatin Organization Histone Ubiquitination Histone Modification Organelle Organization Negative Regulation Of Gene Expression Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Transcription, DNA-templated Negative Regulation Of Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Biosynthetic Process Protein Ubiquitination Nitrogen Compound Metabolic Process Protein Modification By Small Protein Conjugation Negative Regulation Of Cellular Metabolic Process Regulation Of Nitrogen Compound Metabolic Process RNA Metabolic Process Cellular Protein Modification Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Gene Expression Regulation Of RNA Metabolic Process Cellular Macromolecule Biosynthetic Process Histone H2A Monoubiquitination Macromolecule Biosynthetic Process Cellular Metabolic Process Histone H2A Ubiquitination Regulation Of Gene Expression Histone Monoubiquitination Cellular Protein Metabolic Process Biosynthetic Process Protein Monoubiquitination Regulation Of Metabolic Process DNA Metabolic Process Anterior/posterior Pattern Specification Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Protein Metabolic Process Histone H2A-K119 Monoubiquitination Metabolic Process Positive Regulation Of Immature T Cell Proliferation In Thymus
Tagcloud ?		break camptothecin chemotherapeutic collaboratively conjugating doi dsb dsbs dt40 hypersensitivity joining ku70 ligases nhej nonhomologous olaparib onc operate poison polymerization promotion publication rad51 rays recombinase repaired rnf8 topoisomerase ubc13	attains cbx3 collaboration compacted copresence e2f6 e2fs entailing h2a hp1gamma integral l3mbtl1 l3mbtl2 marks mblr mbt monoubiquitination necessitated overlap polycomb prc1 prc1l4 rb1 repression repressive ring1 ring2 rnai
Tagcloud (Difference) ?		break camptothecin chemotherapeutic collaboratively conjugating doi dsb dsbs dt40 hypersensitivity joining ku70 ligases nhej nonhomologous olaparib onc operate poison polymerization promotion publication rad51 rays recombinase repaired rnf8 topoisomerase ubc13	attains cbx3 collaboration compacted copresence e2f6 e2fs entailing h2a hp1gamma integral l3mbtl1 l3mbtl2 marks mblr mbt monoubiquitination necessitated overlap polycomb prc1 prc1l4 rb1 repression repressive ring1 ring2 rnai
Tagcloud (Intersection) ?