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XRCC6 and H2AFX
Number of citations of the paper that reports this interaction (PMID
23145133
)
4
Data Source:
BioGRID
(pull down)
XRCC6
H2AFX
Gene Name
X-ray repair complementing defective repair in Chinese hamster cells 6
H2A histone family, member X
Image
Gene Ontology Annotations
Cellular Component
Nuclear Telomere Cap Complex
Nucleus
Nucleoplasm
Transcription Factor Complex
Nucleolus
Cytosol
Membrane
Ku70:Ku80 Complex
Nonhomologous End Joining Complex
Chromosome, Telomeric Region
Nucleosome
Nuclear Chromatin
Condensed Nuclear Chromosome
Male Germ Cell Nucleus
XY Body
Nucleus
Nucleoplasm
Replication Fork
Site Of Double-strand Break
Extracellular Vesicular Exosome
Molecular Function
DNA Binding
Damaged DNA Binding
Double-stranded DNA Binding
Double-stranded Telomeric DNA Binding
ATP-dependent DNA Helicase Activity
Protein Binding
ATP Binding
Protein C-terminus Binding
Transcription Regulatory Region DNA Binding
Poly(A) RNA Binding
5'-deoxyribose-5-phosphate Lyase Activity
DNA Binding
Damaged DNA Binding
Protein Binding
Enzyme Binding
Histone Binding
Protein Heterodimerization Activity
Biological Process
Telomere Maintenance
DNA Ligation
DNA Repair
Double-strand Break Repair
Double-strand Break Repair Via Nonhomologous End Joining
Transcription, DNA-templated
Brain Development
Viral Process
Positive Regulation Of Type I Interferon Production
DNA Duplex Unwinding
V(D)J Recombination
Innate Immune Response
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of Neurogenesis
Cellular Hyperosmotic Salinity Response
Cellular Response To X-ray
Establishment Of Integrated Proviral Latency
DNA Damage Checkpoint
Double-strand Break Repair Via Homologous Recombination
DNA Repair
Double-strand Break Repair
Nucleosome Assembly
Cellular Response To DNA Damage Stimulus
Spermatogenesis
Response To Ionizing Radiation
Positive Regulation Of DNA Repair
Meiotic Cell Cycle
Pathways
Cytosolic sensors of pathogen-associated DNA
HIV Infection
Processing of DNA ends prior to end rejoining
Integration of provirus
Early Phase of HIV Life Cycle
HIV Life Cycle
Nonhomologous End-joining (NHEJ)
STING mediated induction of host immune responses
Double-Strand Break Repair
IRF3-mediated induction of type I IFN
2-LTR circle formation
Innate Immune System
RNA Polymerase I Chain Elongation
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
Mitotic Prophase
Regulatory RNA pathways
Deposition of new CENPA-containing nucleosomes at the centromere
Cellular Senescence
Signaling by Wnt
Amyloids
NoRC negatively regulates rRNA expression
Packaging Of Telomere Ends
RNF mutants show enhanced WNT signaling and proliferation
Homologous recombination repair of replication-independent double-strand breaks
ATM mediated phosphorylation of repair proteins
DNA Damage/Telomere Stress Induced Senescence
Chromosome Maintenance
ATM mediated response to DNA double-strand break
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
Chromatin organization
formation of the beta-catenin:TCF transactivating complex
Meiotic synapsis
Senescence-Associated Secretory Phenotype (SASP)
Chromatin modifying enzymes
Recruitment of repair and signaling proteins to double-strand breaks
SIRT1 negatively regulates rRNA Expression
Condensation of Prophase Chromosomes
MRN complex relocalizes to nuclear foci
RNA Polymerase I Promoter Clearance
Assembly of the RAD50-MRE11-NBS1 complex at DNA double-strand breaks
M Phase
Telomere Maintenance
Nucleosome assembly
XAV939 inhibits tankyrase, stabilizing AXIN
Double-Strand Break Repair
DNA methylation
Transcriptional regulation by small RNAs
Meiotic recombination
RNA Polymerase I Transcription
Epigenetic regulation of gene expression
Negative epigenetic regulation of rRNA expression
Cell Cycle, Mitotic
PRC2 methylates histones and DNA
RMTs methylate histone arginines
TCF dependent signaling in response to WNT
Oxidative Stress Induced Senescence
Homologous Recombination Repair
RNA Polymerase I Promoter Opening
Signaling by WNT in cancer
Drugs
Diseases
GWAS
Protein-Protein Interactions
126 interactors:
ABCD4
ABL1
ACD
ADCY7
ANXA1
APEX1
AR
ARAP1
ATP6V1E1
BARD1
BAZ1A
BTG1
CAPN11
CBX5
CCNA1
CCT3
CD40
CDCA5
CDK2
CDKN1A
CEBPA
CENPU
CHAF1A
CHEK1
CLTC
CLU
CMTM6
COIL
COPB1
CREBBP
CSNK2A1
CTBP2
DLX2
DNTT
EFNA1
EGFR
EID1
ELF3
EP300
EPS8
FMNL1
GAL3ST4
GSE1
GZMA
GZMB
H2AFX
HERPUD1
HMGA2
HN1L
HOXB7
HOXC4
HOXD4
HSF1
HTT
ILVBL
KAT2A
KAT2B
KIAA0408
LIG3
MAP2K5
MAP4K2
MAPK8
MRE11A
MSX2
NAA15
NCF4
NCL
NCOA6
NHP2L1
NIT1
NOTCH1
PAEP
PAFAH1B3
PARP1
PCNA
PDK1
PDPK1
PDX1
PECAM1
PGAM1
PGR
PIN1
PLGRKT
PNRC2
POR
POU2F1
POU2F2
PRKDC
PRPF40A
PTTG1
QRSL1
RASA1
RBBP4
RGS2
RNF146
RPLP1
RPS10
RRAS2
RUNX2
SDHC
SEP15
SERPINA2
SERPINB9
SGOL1
SIRT3
SKIL
SMAD3
SMAD7
SNTA1
SPARC
TAC1
TADA3
TBCD
TCF4
TERF2
TERF2IP
TERT
TP53
VAV1
VBP1
WBP4
WRN
XRCC5
XRCC6BP1
YWHAZ
ZNF512B
45 interactors:
A2M
ACTB
ALG9
ATM
ATR
BARD1
BMI1
BRCA1
BRCA2
BRD1
CALM1
COPG1
DDX21
DHX9
KAT5
MASP1
MCPH1
MDC1
MRE11A
NBN
NCL
NGFR
OTUB1
PAXIP1
PBK
PPP1CA
PPP2R4
PRKDC
QARS
RNF168
RNF8
RPS6KA3
SMARCA4
SSRP1
SUPT16H
SUPT5H
TAF1C
TAF5L
TERF2
TIAM2
TOPORS
TP53BP1
TSSK6
WRN
XRCC6
Entrez ID
2547
3014
HPRD ID
01071
03465
Ensembl ID
ENSG00000196419
ENSG00000188486
Uniprot IDs
B1AHC8
B1AHC9
P12956
P16104
PDB IDs
1JEQ
1JEY
1JJR
3RZX
2D31
2DYP
3SHV
3SQD
3SZM
3U3Z
Enriched GO Terms of Interacting Partners
?
Regulation Of Nitrogen Compound Metabolic Process
Positive Regulation Of Metabolic Process
Negative Regulation Of Cellular Metabolic Process
Regulation Of Metabolic Process
Positive Regulation Of Cellular Metabolic Process
Cell Cycle
Heterocycle Metabolic Process
Nucleobase-containing Compound Metabolic Process
Cellular Aromatic Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Nitrogen Compound Metabolic Process
Cellular Macromolecule Biosynthetic Process
Regulation Of RNA Metabolic Process
RNA Biosynthetic Process
Macromolecule Biosynthetic Process
Response To Stress
Regulation Of Gene Expression
Positive Regulation Of Cellular Biosynthetic Process
RNA Metabolic Process
Regulation Of Transcription, DNA-templated
Chromosome Organization
Regulation Of Cell Death
Regulation Of Cellular Component Organization
Regulation Of Nucleic Acid-templated Transcription
Regulation Of Apoptotic Process
Cell Cycle Process
Regulation Of RNA Biosynthetic Process
Transcription, DNA-templated
Response To Organic Substance
Cellular Response To Stress
Organelle Organization
Positive Regulation Of Gene Expression
Gene Expression
DNA Metabolic Process
Positive Regulation Of Transcription, DNA-templated
Negative Regulation Of Apoptotic Process
Negative Regulation Of Programmed Cell Death
Regulation Of Cell Cycle
Telomere Maintenance
Positive Regulation Of Macromolecule Biosynthetic Process
Regulation Of Cellular Process
Mitotic Cell Cycle
Embryo Development
Negative Regulation Of Cell Death
Negative Regulation Of Biosynthetic Process
Cellular Response To DNA Damage Stimulus
Biosynthetic Process
Regulation Of Catalytic Activity
Cellular Metabolic Process
Cellular Response To Organic Substance
DNA Metabolic Process
Double-strand Break Repair
DNA Repair
Cellular Response To DNA Damage Stimulus
Chromosome Organization
DNA Recombination
Organelle Organization
Cellular Response To Stress
Response To Ionizing Radiation
Double-strand Break Repair Via Homologous Recombination
Recombinational Repair
Response To Radiation
Chromatin Organization
Response To Stress
Regulation Of Metabolic Process
Negative Regulation Of Cellular Metabolic Process
Chromatin Modification
Nucleobase-containing Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Response To Abiotic Stimulus
Telomere Maintenance
Nitrogen Compound Metabolic Process
Positive Regulation Of Metabolic Process
Cell Cycle
Positive Regulation Of Cellular Metabolic Process
Signal Transduction In Response To DNA Damage
Regulation Of Protein Metabolic Process
Cellular Metabolic Process
Histone Modification
Signal Transduction By P53 Class Mediator
Response To Stimulus
Negative Regulation Of Cell Cycle
Regulation Of Cell Cycle
Cellular Response To Stimulus
Cellular Protein Modification Process
DNA Damage Response, Signal Transduction By P53 Class Mediator
Regulation Of Nitrogen Compound Metabolic Process
Peptidyl-amino Acid Modification
DNA Damage Checkpoint
Peptidyl-lysine Modification
Cell Cycle Process
Regulation Of Cellular Protein Metabolic Process
DNA Replication
Regulation Of Gene Expression
Response To Gamma Radiation
Negative Regulation Of Protein Metabolic Process
Histone Acetylation
Double-strand Break Repair Via Nonhomologous End Joining
Tagcloud
?
brca2
cellularity
cg
chance
copyright
cytopenia
genesis
genotype
genotyped
gg
heterozygote
hypercellular
john
karyotype
lig4
ltd
normocellular
polymorphism
polymorphisms
rad51
rs1801320
rs1805388
rs2267437
rs3835
rs4793191
rs9567623
sons
wiley
xrcc5
Tagcloud (Difference)
?
brca2
cellularity
cg
chance
copyright
cytopenia
genesis
genotype
genotyped
gg
heterozygote
hypercellular
john
karyotype
lig4
ltd
normocellular
polymorphism
polymorphisms
rad51
rs1801320
rs1805388
rs2267437
rs3835
rs4793191
rs9567623
sons
wiley
xrcc5
Tagcloud (Intersection)
?