MAD1L1 and SPATA18

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MAD1L1	SPATA18
Description		mitotic arrest deficient 1 like 1	spermatogenesis associated 18
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Spindle Pole Nucleus Nuclear Envelope Chromosome Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Nuclear Pore Nuclear Basket Mitotic Spindle Mitotic Spindle Pole MAD1 Complex Mitotic Spindle Assembly Checkpoint MAD1-MAD2 Complex	Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Outer Membrane Mitochondrial Matrix Cytosol Membrane Intracellular Membrane-bounded Organelle Intracellular Membraneless Organelle
	Molecular Function	Protein Binding Identical Protein Binding Kinetochore Binding	Protein Binding Lipid Binding Identical Protein Binding Molecular Condensate Scaffold Activity Cardiolipin Binding
	Biological Process	Mitotic Spindle Assembly Checkpoint Signaling Negative Regulation Of T Cell Proliferation Thymus Development Cell Division Attachment Of Mitotic Spindle Microtubules To Kinetochore Regulation Of Metaphase Plate Congression Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Regulation Of Mitotic Cell Cycle Phase Transition Deactivation Of Mitotic Spindle Assembly Checkpoint	CDP-diacylglycerol Biosynthetic Process Cardiolipin Biosynthetic Process Mitochondrial Protein Catabolic Process Mitophagy By Internal Vacuole Formation Cardiolipin Acyl-chain Remodeling Positive Regulation Of Cardiolipin Metabolic Process
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Adult body size ( 32376654) Adverse response to drug ( 30420678) Age at first birth ( 34211149) Age at first sexual intercourse ( 34211149 27089180) Alcohol consumption (drinks per week) ( 30643258) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Anthropometric traits (multi-trait analysis) ( 30166351) Anxiety ( 31906708) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 21926972 34002096 28115744 27329760) Bitter alcoholic beverage consumption ( 31046077) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Coronary artery disease ( 29212778 33020668) Dimensional psychopathology (Social) ( 29496196) Disruptive behavior disorder and attention deficit hyperactivity disorder ( 33495439) Gastroesophageal reflux disease ( 34187846 31527586) General factor of neuroticism ( 30867560) Gut microbiota relative abundance (Streptococcus) ( 33208821) Hand grip strength ( 29691431) Idiopathic pulmonary fibrosis ( 31710517) Longevity ( 20834067) Mosaic loss of chromosome Y (Y chromosome dosage) ( 28346444 31624269) Myocardial infarction ( 33532862) Number of sexual partners ( 30643258) Platelet count ( 32888494) Plateletcrit ( 32888494) Prostate cancer ( 29892016) Prostate cancer (advanced) ( 29892016) Refractive error ( 32231278) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814) Risk-taking tendency (4-domain principal component model) ( 30643258) Rosacea symptom severity ( 29771307) Schizophrenia ( 30285260 22688191 28991256 23974872 29483656) Schizophrenia or bipolar disorder ( 24280982) Schizophrenia, schizoaffective disorder or bipolar disorder ( 24166486) Sepsis (28-day mortality) ( 32592749) Sleep duration (short sleep) ( 30846698) Smoking initiation ( 33082346) Smoking status (ever vs never smokers) ( 30643258) Superior frontal gyrus volume ( 31530798) Superior temporal gyrus volume ( 31530798) Systolic blood pressure ( 30578418) Testicular germ cell tumor ( 28604732 23666239 28604728) Vaginal microbiome composition (Shannon diversity index) ( 32723796)	Height ( 31562340) Hip circumference adjusted for BMI ( 28552196) Platelet count ( 29403010) Type 2 diabetes ( 30054458) Uterine fibroids ( 30194396)
Interacting Genes		63 interacting genes: ALOX5 AMOTL2 ATG5 BIRC2 CAPN7 CCDC57 CCHCR1 CDC37 CDK18 CIMIP4 COIL CWF19L2 DRC4 FAM131C FAM90A1 FXR1 GPKOW HAUS1 HDAC1 HDAC2 KIF9 LENG1 LGALSL LMO1 LMO3 LNX1 MAD2L1 MAX MFAP1 MLX NDC80 NEBL NEK2 NINL NONO NTAQ1 PIBF1 PML PPP1R18 PSMA1 RNF8 SIN3A SIN3B SPATA18 SPATA2 SUPT5H SYT17 SYT6 TCAF1 TEX11 TPM1 TPM3 TPR TRIM29 TSC22D3 TSGA10 TSHZ3 TUBGCP4 UBC UBTF USP15 YJU2 ZSCAN32	13 interacting genes: AIMP2 CARD10 CCDC102B DRC4 EFHC2 GOLGA2 HOXA1 LRIF1 MAD1L1 PAXIP1 PIBF1 TACC3 TGM7
Entrez ID		8379	132671
HPRD ID		04065	14050
Ensembl ID		ENSG00000002822	ENSG00000163071
Uniprot IDs		Q9Y6D9	A0A140VKF4 Q8TC71
PDB IDs		1GO4 4DZO 7B1F 7B1H 7B1J
Enriched GO Terms of Interacting Partners?		Cytoplasm Sin3-type Complex Nucleoplasm Protein Binding Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Linear Amides Chromatin Binding Protein Lysine Delactylase Activity Fungiform Papilla Formation Positive Regulation Of Cell Cycle Checkpoint Spindle Assembly Nuclear Chromosome Segregation Protein Decrotonylase Activity Histone Decrotonylase Activity Muscle Thin Filament Tropomyosin Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Microtubule Cytoskeleton Organization Hair Follicle Placode Formation Negative Regulation Of Stem Cell Population Maintenance Membraneless Organelle Assembly Mitotic Spindle Assembly Checkpoint Signaling Regulation Of Mitotic Cell Cycle Cellular Response To Dopamine Negative Regulation Of Mitotic Metaphase/anaphase Transition Negative Regulation Of Chromosome Organization Intracellular Membraneless Organelle Negative Regulation Of RNA Metabolic Process Response To Dopamine Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Mitotic Sister Chromatid Segregation Stress Fiber Centrosome Cytoskeleton Negative Regulation Of Mitotic Nuclear Division Sister Chromatid Segregation Histone Deacetylase Complex Histone Deacetylase Activity, Hydrolytic Mechanism Kinetochore Spindle Organization Podosome Nuclear Pore Complex Assembly Microtubule-based Process Regulation Of Defense Response Negative Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Factor Binding Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Stem Cell Population Maintenance Calcium-dependent Phospholipid Binding Protein Lysine Deacetylase Activity	Positive Regulation Of Protein Modification Process Ciliary Basal Body Cytoskeleton Mitotic Spindle Organization Regulation Of Protein Modification Process Mitotic Spindle Microtubule Cytoskeleton Organization Involved In Mitosis Centriolar Satellite Microtubule-based Process Positive Regulation Of Protein Metabolic Process Spindle Organization Spindle Pole Microtubule Cytoskeleton Organization Activation Of Protein Kinase Activity Mitotic Spindle Assembly Semicircular Canal Formation MAD1 Complex Abducens Nerve Formation Optokinetic Behavior Mitotic Spindle Assembly Checkpoint MAD1-MAD2 Complex Negative Regulation Of Prostaglandin Biosynthetic Process Microtubule Spindle Assembly Deactivation Of Mitotic Spindle Assembly Checkpoint Negative Regulation Of Tyrosine Phosphorylation Of STAT Protein Interleukin-4 Receptor Binding Chorion Development
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?