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MAD1L1 and SIN3B
Number of citations of the paper that reports this interaction (PubMedID
11101889
)
0
Data Source:
HPRD
(two hybrid, in vitro, in vivo)
MAD1L1
SIN3B
Description
mitotic arrest deficient 1 like 1
SIN3 transcription regulator family member B
Image
GO Annotations
Cellular Component
Chromosome, Centromeric Region
Kinetochore
Spindle Pole
Nucleus
Nuclear Envelope
Chromosome
Cytoplasm
Centrosome
Spindle
Cytosol
Cytoskeleton
Nuclear Pore Nuclear Basket
Mitotic Spindle
Mitotic Spindle Pole
MAD1 Complex
Mitotic Spindle Assembly Checkpoint MAD1-MAD2 Complex
Chromatin
X Chromosome
Y Chromosome
XY Body
Nucleus
Nucleoplasm
Cytoplasm
Autosome
Sin3-type Complex
Molecular Function
Protein Binding
Identical Protein Binding
Kinetochore Binding
Chromatin Binding
Transcription Corepressor Activity
Protein Binding
Biological Process
Mitotic Spindle Assembly Checkpoint Signaling
Negative Regulation Of T Cell Proliferation
Thymus Development
Cell Division
Attachment Of Mitotic Spindle Microtubules To Kinetochore
Regulation Of Metaphase Plate Congression
Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint
Regulation Of Mitotic Cell Cycle Phase Transition
Deactivation Of Mitotic Spindle Assembly Checkpoint
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of DNA-templated Transcription
Negative Regulation Of Cell Migration
Negative Regulation Of DNA-templated Transcription
Pathways
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
Mitotic Prometaphase
EML4 and NUDC in mitotic spindle formation
NoRC negatively regulates rRNA expression
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Drugs
Diseases
GWAS
Adult body size (
32376654
)
Adverse response to drug (
30420678
)
Age at first birth (
34211149
)
Age at first sexual intercourse (
34211149
27089180
)
Alcohol consumption (drinks per week) (
30643258
)
Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) (
31835028
)
Anthropometric traits (multi-trait analysis) (
30166351
)
Anxiety (
31906708
)
Autism spectrum disorder or schizophrenia (
28540026
)
Bipolar disorder (
21926972
34002096
28115744
27329760
)
Bitter alcoholic beverage consumption (
31046077
)
Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) (
31374203
)
Coronary artery disease (
29212778
33020668
)
Dimensional psychopathology (Social) (
29496196
)
Disruptive behavior disorder and attention deficit hyperactivity disorder (
33495439
)
Gastroesophageal reflux disease (
34187846
31527586
)
General factor of neuroticism (
30867560
)
Gut microbiota relative abundance (Streptococcus) (
33208821
)
Hand grip strength (
29691431
)
Idiopathic pulmonary fibrosis (
31710517
)
Longevity (
20834067
)
Mosaic loss of chromosome Y (Y chromosome dosage) (
28346444
31624269
)
Myocardial infarction (
33532862
)
Number of sexual partners (
30643258
)
Platelet count (
32888494
)
Plateletcrit (
32888494
)
Prostate cancer (
29892016
)
Prostate cancer (advanced) (
29892016
)
Refractive error (
32231278
)
Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) (
26503814
)
Risk-taking tendency (4-domain principal component model) (
30643258
)
Rosacea symptom severity (
29771307
)
Schizophrenia (
30285260
22688191
28991256
23974872
29483656
)
Schizophrenia or bipolar disorder (
24280982
)
Schizophrenia, schizoaffective disorder or bipolar disorder (
24166486
)
Sepsis (28-day mortality) (
32592749
)
Sleep duration (short sleep) (
30846698
)
Smoking initiation (
33082346
)
Smoking status (ever vs never smokers) (
30643258
)
Superior frontal gyrus volume (
31530798
)
Superior temporal gyrus volume (
31530798
)
Systolic blood pressure (
30578418
)
Testicular germ cell tumor (
28604732
23666239
28604728
)
Vaginal microbiome composition (Shannon diversity index) (
32723796
)
Interacting Genes
63 interacting genes:
ALOX5
AMOTL2
ATG5
BIRC2
CAPN7
CCDC57
CCHCR1
CDC37
CDK18
CIMIP4
COIL
CWF19L2
DRC4
FAM131C
FAM90A1
FXR1
GPKOW
HAUS1
HDAC1
HDAC2
KIF9
LENG1
LGALSL
LMO1
LMO3
LNX1
MAD2L1
MAX
MFAP1
MLX
NDC80
NEBL
NEK2
NINL
NONO
NTAQ1
PIBF1
PML
PPP1R18
PSMA1
RNF8
SIN3A
SIN3B
SPATA18
SPATA2
SUPT5H
SYT17
SYT6
TCAF1
TEX11
TPM1
TPM3
TPR
TRIM29
TSC22D3
TSGA10
TSHZ3
TUBGCP4
UBC
UBTF
USP15
YJU2
ZSCAN32
20 interacting genes:
AURKA
COPS2
H3-4
HDAC1
HDAC9
IKZF1
IKZF4
MAD1L1
MXD1
MXI1
NR1D2
REST
RNF220
SETDB1
SMARCA2
SMARCA4
SMARCB1
SMARCE1
TP53
ZBTB16
Entrez ID
8379
23309
HPRD ID
04065
09691
Ensembl ID
ENSG00000002822
ENSG00000127511
Uniprot IDs
Q9Y6D9
B7Z392
M0QYC5
O75182
PDB IDs
1GO4
4DZO
7B1F
7B1H
7B1J
8BPA
8BPB
8BPC
8C60
Enriched GO Terms of Interacting Partners
?
Cytoplasm
Sin3-type Complex
Nucleoplasm
Protein Binding
Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint
Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Linear Amides
Chromatin Binding
Protein Lysine Delactylase Activity
Fungiform Papilla Formation
Positive Regulation Of Cell Cycle Checkpoint
Spindle Assembly
Nuclear Chromosome Segregation
Protein Decrotonylase Activity
Histone Decrotonylase Activity
Muscle Thin Filament Tropomyosin
Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint
Microtubule Cytoskeleton Organization
Hair Follicle Placode Formation
Negative Regulation Of Stem Cell Population Maintenance
Membraneless Organelle Assembly
Mitotic Spindle Assembly Checkpoint Signaling
Regulation Of Mitotic Cell Cycle
Cellular Response To Dopamine
Negative Regulation Of Mitotic Metaphase/anaphase Transition
Negative Regulation Of Chromosome Organization
Intracellular Membraneless Organelle
Negative Regulation Of RNA Metabolic Process
Response To Dopamine
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Mitotic Sister Chromatid Segregation
Stress Fiber
Centrosome
Cytoskeleton
Negative Regulation Of Mitotic Nuclear Division
Sister Chromatid Segregation
Histone Deacetylase Complex
Histone Deacetylase Activity, Hydrolytic Mechanism
Kinetochore
Spindle Organization
Podosome
Nuclear Pore Complex Assembly
Microtubule-based Process
Regulation Of Defense Response
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
DNA-binding Transcription Factor Binding
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Positive Regulation Of Stem Cell Population Maintenance
Calcium-dependent Phospholipid Binding
Protein Lysine Deacetylase Activity
Positive Regulation Of Stem Cell Population Maintenance
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Chromatin Organization
Negative Regulation Of RNA Metabolic Process
Chromatin Remodeling
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Biosynthetic Process
Regulation Of Stem Cell Population Maintenance
BBAF Complex
DNA Binding
Negative Regulation Of Macromolecule Metabolic Process
NpBAF Complex
NBAF Complex
Negative Regulation Of Metabolic Process
Regulation Of Cell Differentiation
Negative Regulation Of Transcription By RNA Polymerase II
Nucleoplasm
Protein-containing Complex
Nucleus
Regulation Of Transcription By RNA Polymerase II
Regulation Of Cell Development
Regulation Of Primary Metabolic Process
Regulation Of DNA-templated Transcription
Epigenetic Regulation Of Gene Expression
Regulation Of RNA Biosynthetic Process
Host-mediated Perturbation Of Viral Transcription
Regulation Of Nucleotide-excision Repair
SWI/SNF Complex
Regulation Of Metabolic Process
Regulation Of Mitotic Metaphase/anaphase Transition
Regulation Of Developmental Process
Regulation Of RNA Metabolic Process
Regulation Of G0 To G1 Transition
Regulation Of Mitotic Cell Cycle Phase Transition
Regulation Of Gene Expression
Nucleosomal DNA Binding
Regulation Of Sister Chromatid Segregation
Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Myoblast Differentiation
Positive Regulation Of T Cell Differentiation
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Chromosome Organization
Positive Regulation Of Cell Differentiation
Regulation Of Chromosome Segregation
Brahma Complex
Positive Regulation Of Lymphocyte Differentiation
Positive Regulation Of Cell Development
RSC-type Complex
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Tagcloud (Difference)
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Tagcloud (Intersection)
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