MAD1L1 and CCHCR1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid, two hybrid)

		MAD1L1	CCHCR1
Description		mitotic arrest deficient 1 like 1	coiled-coil alpha-helical rod protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Spindle Pole Nucleus Nuclear Envelope Chromosome Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Nuclear Pore Nuclear Basket Mitotic Spindle Mitotic Spindle Pole MAD1 Complex Mitotic Spindle Assembly Checkpoint MAD1-MAD2 Complex	Nucleus Cytoplasm Centriole Cytosol
	Molecular Function	Protein Binding Identical Protein Binding Kinetochore Binding	Protein Binding Identical Protein Binding
	Biological Process	Mitotic Spindle Assembly Checkpoint Signaling Negative Regulation Of T Cell Proliferation Thymus Development Cell Division Attachment Of Mitotic Spindle Microtubules To Kinetochore Regulation Of Metaphase Plate Congression Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Regulation Of Mitotic Cell Cycle Phase Transition Deactivation Of Mitotic Spindle Assembly Checkpoint	Protein Export From Nucleus Cell Differentiation
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Adult body size ( 32376654) Adverse response to drug ( 30420678) Age at first birth ( 34211149) Age at first sexual intercourse ( 34211149 27089180) Alcohol consumption (drinks per week) ( 30643258) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Anthropometric traits (multi-trait analysis) ( 30166351) Anxiety ( 31906708) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 21926972 34002096 28115744 27329760) Bitter alcoholic beverage consumption ( 31046077) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Coronary artery disease ( 29212778 33020668) Dimensional psychopathology (Social) ( 29496196) Disruptive behavior disorder and attention deficit hyperactivity disorder ( 33495439) Gastroesophageal reflux disease ( 34187846 31527586) General factor of neuroticism ( 30867560) Gut microbiota relative abundance (Streptococcus) ( 33208821) Hand grip strength ( 29691431) Idiopathic pulmonary fibrosis ( 31710517) Longevity ( 20834067) Mosaic loss of chromosome Y (Y chromosome dosage) ( 28346444 31624269) Myocardial infarction ( 33532862) Number of sexual partners ( 30643258) Platelet count ( 32888494) Plateletcrit ( 32888494) Prostate cancer ( 29892016) Prostate cancer (advanced) ( 29892016) Refractive error ( 32231278) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814) Risk-taking tendency (4-domain principal component model) ( 30643258) Rosacea symptom severity ( 29771307) Schizophrenia ( 30285260 22688191 28991256 23974872 29483656) Schizophrenia or bipolar disorder ( 24280982) Schizophrenia, schizoaffective disorder or bipolar disorder ( 24166486) Sepsis (28-day mortality) ( 32592749) Sleep duration (short sleep) ( 30846698) Smoking initiation ( 33082346) Smoking status (ever vs never smokers) ( 30643258) Superior frontal gyrus volume ( 31530798) Superior temporal gyrus volume ( 31530798) Systolic blood pressure ( 30578418) Testicular germ cell tumor ( 28604732 23666239 28604728) Vaginal microbiome composition (Shannon diversity index) ( 32723796)	Asthma ( 31619474) Asthma (childhood onset) ( 31619474) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Chronic obstructive pulmonary disease-related biomarkers ( 23144326) Feeling nervous ( 29500382) Head and neck squamous cell carcinoma ( 32276964) Hematology traits ( 23263863) Hemoglobin ( 32888494) Hip circumference adjusted for BMI ( 34021172) Inflammatory bowel disease ( 28067908) Malaria ( 31844061) Mean spheric corpuscular volume ( 32888494) Microalbuminuria ( 31511532) Monocyte percentage of white cells ( 32888494) Multiple myeloma ( 23955597) Nevirapine-induced rash ( 21810746) Night sleep phenotypes ( 27126917) Prostate cancer ( 21743467) Psoriasis ( 30921485) Reticulocyte count ( 32888494) Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS-TEN) ( 21912425) Ulcerative colitis ( 28067908) Urinary albumin-to-creatinine ratio ( 31511532) Waist-to-hip ratio adjusted for BMI ( 34021172) White blood cell count ( 21738480)
Interacting Genes		63 interacting genes: ALOX5 AMOTL2 ATG5 BIRC2 CAPN7 CCDC57 CCHCR1 CDC37 CDK18 CIMIP4 COIL CWF19L2 DRC4 FAM131C FAM90A1 FXR1 GPKOW HAUS1 HDAC1 HDAC2 KIF9 LENG1 LGALSL LMO1 LMO3 LNX1 MAD2L1 MAX MFAP1 MLX NDC80 NEBL NEK2 NINL NONO NTAQ1 PIBF1 PML PPP1R18 PSMA1 RNF8 SIN3A SIN3B SPATA18 SPATA2 SUPT5H SYT17 SYT6 TCAF1 TEX11 TPM1 TPM3 TPR TRIM29 TSC22D3 TSGA10 TSHZ3 TUBGCP4 UBC UBTF USP15 YJU2 ZSCAN32	161 interacting genes: ABI1 ABI2 AIRIM ALAS1 AMOTL2 ANKRD11 ATG5 BFSP1 BICD2 BLOC1S2 BLOC1S6 C1orf94 CARD9 CBY2 CCDC102B CCDC13 CCDC136 CCDC197 CCDC33 CCDC88B CCNC CDC37 CDR2 CDR2L CDSN CEP55 CEP57 CEP63 CFAP53 CIMIP4 CNN1 CNOT2 CRACR2A CTAG1A CTAG1B DEUP1 DISC1 DMAP1 DRC4 DTNB DYDC1 EFHC2 EXOC4 EXOC7 EXOC8 FSD2 GLRX3 GNG13 GOLGA2 GOLGA6L9 GRAP2 HAUS1 HAUS8 HDDC3 HGFAC HOMEZ HOOK2 HSF2BP HSPB1 IFT20 IKBKG IKZF3 ING5 KIAA0753 KIFC3 KRT13 KRT15 KRT16 KRT18 KRT19 KRT24 KRT27 KRT31 KRT34 KRT35 KRT36 KRT75 LENG1 LHX8 LZTS1 MAD1L1 MBD3 MCRS1 MED4 MIA2 MID2 MTUS2 NAB2 NDC80 NFKBID NINL NME7 NTAQ1 NUP54 NUP62 NUTM1 OIP5 PCM1 PFDN6 PIAS2 PIBF1 PKP2 PLEKHA7 POLD2 POLR2C POU6F2 PPP1R13B PRDM6 PRKCG PROSER3 RABGEF1 RALBP1 RBM17 RBM41 RCOR3 RINT1 RUSC1 SAMD11 SAT1 SMARCE1 SORBS3 SPAG5 SPG21 SSX2IP STAR STARD4 STMN2 STX11 SYCE1 SYCE1L TACC3 TADA2A TEKT1 TEX9 TFIP11 TPM1 TPM3 TRAF1 TRAF2 TRAF4 TRIM27 TRIM54 TRIML2 TSG101 TSGA10 TSHZ3 TXLNA TXLNB USHBP1 VPS52 VPS9D1 WASHC3 ZBTB16 ZFYVE19 ZGPAT ZNF620 ZNF629 ZNF655 ZNF774 ZRANB1 ZWINT
Entrez ID		8379	54535
HPRD ID		04065	05607
Ensembl ID		ENSG00000002822	ENSG00000204536
Uniprot IDs		Q9Y6D9	A0A1U9X7G6 B0S7V6 B4DIA2 D2IYK9 M1T2K8 M1TIV4 Q2TB68 Q769H0 Q8TD31
PDB IDs		1GO4 4DZO 7B1F 7B1H 7B1J
Enriched GO Terms of Interacting Partners?		Cytoplasm Sin3-type Complex Nucleoplasm Protein Binding Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Linear Amides Chromatin Binding Protein Lysine Delactylase Activity Fungiform Papilla Formation Positive Regulation Of Cell Cycle Checkpoint Spindle Assembly Nuclear Chromosome Segregation Protein Decrotonylase Activity Histone Decrotonylase Activity Muscle Thin Filament Tropomyosin Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Microtubule Cytoskeleton Organization Hair Follicle Placode Formation Negative Regulation Of Stem Cell Population Maintenance Membraneless Organelle Assembly Mitotic Spindle Assembly Checkpoint Signaling Regulation Of Mitotic Cell Cycle Cellular Response To Dopamine Negative Regulation Of Mitotic Metaphase/anaphase Transition Negative Regulation Of Chromosome Organization Intracellular Membraneless Organelle Negative Regulation Of RNA Metabolic Process Response To Dopamine Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Mitotic Sister Chromatid Segregation Stress Fiber Centrosome Cytoskeleton Negative Regulation Of Mitotic Nuclear Division Sister Chromatid Segregation Histone Deacetylase Complex Histone Deacetylase Activity, Hydrolytic Mechanism Kinetochore Spindle Organization Podosome Nuclear Pore Complex Assembly Microtubule-based Process Regulation Of Defense Response Negative Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Factor Binding Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Stem Cell Population Maintenance Calcium-dependent Phospholipid Binding Protein Lysine Deacetylase Activity	Cytoskeleton Cytoskeleton Organization Supramolecular Fiber Organization Microtubule-based Process Centrosome Protein Binding Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Intermediate Filament Organization Organelle Organization Structural Constituent Of Skin Epidermis Centriolar Satellite Keratin Filament Intermediate Filament Structural Molecule Activity Cytoplasm Spindle Pole Cytoskeleton-dependent Intracellular Transport Organelle Localization Microtubule Organizing Center Organization Microtubule Microtubule-based Transport Microtubule Cytoskeleton Organization Cytosol Flemming Body Transport Along Microtubule Microtubule-based Movement Organelle Assembly Protein Localization To Centrosome Identical Protein Binding Microtubule Binding Centrosome Cycle Protein Localization To Cytoskeleton Signaling Adaptor Activity Establishment Of Localization In Cell Intracellular Transport Cell Division Centriole Regulation Of Microtubule Cytoskeleton Organization Epithelial Cell Differentiation Cellular Localization Microtubule Organizing Center Cilium Assembly Ciliary Basal Body Structural Constituent Of Cytoskeleton Establishment Of Organelle Localization Vesicle Tethering Involved In Exocytosis Axonemal A Tubule Inner Sheath Thioesterase Binding Syntaxin Binding
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