MAD1L1 and CWF19L2

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		MAD1L1	CWF19L2
Gene Name		MAD1 mitotic arrest deficient-like 1 (yeast)	CWF19-like 2, cell cycle control (S. pombe)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Kinetochore Condensed Chromosome Kinetochore Nucleus Nuclear Pore Cytoplasm Centrosome Spindle Cytosol Actin Cytoskeleton Mitotic Spindle
	Molecular Function	Protein Binding	Catalytic Activity
	Biological Process	Mitotic Cell Cycle Mitotic Nuclear Division Mitotic Cell Cycle Checkpoint Mitotic Spindle Assembly Checkpoint Cell Division Regulation Of Metaphase Plate Congression	Metabolic Process
Pathways		Mitotic Spindle Checkpoint Amplification of signal from the kinetochores Mitotic Prometaphase Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Cell Cycle Checkpoints Mitotic Anaphase Mitotic Metaphase and Anaphase Cell Cycle, Mitotic M Phase
Drugs
Diseases
GWAS		Bipolar disorder ( 21926972) Longevity ( 20834067) Schizophrenia ( 22688191) Testicular germ cell tumor ( 23666239)
Protein-Protein Interactions		38 interactors: ALOX5 AMOTL2 BAG5 CCDC94 CCHCR1 COIL CWF19L2 FAM131C HAUS1 HDAC1 HDAC2 LGALSL MAD2L1 MAX MFAP1 MLX NDC80 NEBL NEK2 NINL NONO PSMA1 RNF8 SIN3A SIN3B SPATA2 TEX11 TPM1 TPM3 TPR TRIM29 TSC22D3 TSHZ3 TUBGCP4 UBC UBTF USP15 ZSCAN32	27 interactors: APP BRCA1 CALCOCO1 CALCOCO2 CARD9 CCDC136 CCDC57 FAM9B HOOK2 KRT40 LHX9 LZTS2 MAD1L1 MEOX1 MTUS2 NAB2 NDEL1 RINT1 SF3B4 STX11 TAX1BP1 TP53BP2 TRIM27 TRIM37 TRIM54 TRIM9 VIM
Entrez ID		8379	143884
HPRD ID		04065	13102
Ensembl ID		ENSG00000002822	ENSG00000152404
Uniprot IDs		B3KR41 Q9Y6D9	Q2TBE0
PDB IDs		1GO4 4DZO
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Gene Expression Mitotic Cell Cycle Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Mitotic Cell Cycle Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Chromosome Organization Cell Cycle Process Negative Regulation Of Biosynthetic Process Cell Cycle Organelle Organization Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Cell Death Histone Deacetylation Protein Deacetylation Negative Regulation Of Ubiquitin-protein Transferase Activity Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Gene Expression, Epigenetic Mitotic Nuclear Division Regulation Of Ubiquitin-protein Transferase Activity RNA Biosynthetic Process Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Protein Ubiquitination Positive Regulation Of Cell Cycle Process Histone Modification Regulation Of Protein Catabolic Process Regulation Of Cell Cycle Phase Transition Chromatin Modification Regulation Of Apoptotic Process Regulation Of Mitotic Cell Cycle Transcription From RNA Polymerase II Promoter G2/M Transition Of Mitotic Cell Cycle Cell Division Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Proteasomal Protein Catabolic Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Cell Death Regulation Of Cell Cycle Regulation Of Proteolysis Negative Regulation Of Cell Cycle Positive Regulation Of Spindle Checkpoint Transcription, DNA-templated Positive Regulation Of Cell Cycle Chromatin Organization	Negative Regulation Of Centriole Replication Intracellular Receptor Signaling Pathway Regulation Of Centriole Replication Regulation Of Cell Cycle Process Innate Immune Response Negative Regulation Of Centrosome Duplication Regulation Of Organelle Organization Regulation Of Cell Cycle Regulation Of Cellular Component Organization Regulation Of Transcription From RNA Polymerase III Promoter Establishment Of Localization In Cell Intracellular Transport Regulation Of Microtubule Cytoskeleton Organization Regulation Of Cellular Process Negative Regulation Of Cytoskeleton Organization Regulation Of Microtubule-based Process Microtubule-based Process Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Negative Regulation Of Cell Cycle Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Regulation Of Centrosome Duplication Protein Autoubiquitination Establishment Of Vesicle Localization Immune Response Cellular Localization Vesicle Localization Regulation Of Centrosome Cycle Axon Cargo Transport Centrosome Cycle Cell Cycle Defense Response Gonad Morphogenesis Positive Regulation Of Histone H4-K20 Methylation Positive Regulation Of Histone H4-K16 Acetylation Regulation Of Signal Transduction Involved In Mitotic G2 DNA Damage Checkpoint Regulation Of Metaphase Plate Congression Regulation Of Cytoskeleton Organization Secretion By Cell Organelle Organization Synaptic Vesicle Exocytosis Regulation Of Cytokine Production Vesicle-mediated Transport Cellular Process Apoptotic Process Negative Regulation Of NF-kappaB Transcription Factor Activity Protein Ubiquitination Regulation Of Metabolic Process Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Gene Expression
Tagcloud ?		adverse altered aneuploidy arrest biomarker carcinogenesis characteristic checkpoint checkpoints chromosomal clinicopathological contraindication correlation defects instability mammary microarray mitotic nuclei ones os pacilitaxel predict shorter subtypes taxol undergone whose worse
Tagcloud (Difference) ?		adverse altered aneuploidy arrest biomarker carcinogenesis characteristic checkpoint checkpoints chromosomal clinicopathological contraindication correlation defects instability mammary microarray mitotic nuclei ones os pacilitaxel predict shorter subtypes taxol undergone whose worse
Tagcloud (Intersection) ?