MAD1L1 and TSHZ3

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		MAD1L1	TSHZ3
Gene Name		MAD1 mitotic arrest deficient-like 1 (yeast)	teashirt zinc finger homeobox 3
Image
Gene Ontology Annotations	Cellular Component	Kinetochore Condensed Chromosome Kinetochore Nucleus Nuclear Pore Cytoplasm Centrosome Spindle Cytosol Actin Cytoskeleton Mitotic Spindle	Nucleus Nucleoplasm Mitochondrion Growth Cone
	Molecular Function	Protein Binding	DNA Binding Chromatin Binding Protein Binding Metal Ion Binding
	Biological Process	Mitotic Cell Cycle Mitotic Nuclear Division Mitotic Cell Cycle Checkpoint Mitotic Spindle Assembly Checkpoint Cell Division Regulation Of Metaphase Plate Congression	Metanephros Development Ureteric Bud Development In Utero Embryonic Development Regulation Of Respiratory Gaseous Exchange By Neurological System Process Transcription, DNA-templated Lung Development Negative Regulation Of Transcription, DNA-templated Musculoskeletal Movement Sensory Perception Of Touch Positive Regulation Of Smooth Muscle Cell Differentiation Kidney Morphogenesis Ureteric Peristalsis Ureter Smooth Muscle Cell Differentiation Kidney Smooth Muscle Cell Differentiation
Pathways		Mitotic Spindle Checkpoint Amplification of signal from the kinetochores Mitotic Prometaphase Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Cell Cycle Checkpoints Mitotic Anaphase Mitotic Metaphase and Anaphase Cell Cycle, Mitotic M Phase
Drugs
Diseases
GWAS		Bipolar disorder ( 21926972) Longevity ( 20834067) Schizophrenia ( 22688191) Testicular germ cell tumor ( 23666239)	Cognitive performance ( 19734545) Phospholipid levels (plasma) ( 21829377)
Protein-Protein Interactions		38 interactors: ALOX5 AMOTL2 BAG5 CCDC94 CCHCR1 COIL CWF19L2 FAM131C HAUS1 HDAC1 HDAC2 LGALSL MAD2L1 MAX MFAP1 MLX NDC80 NEBL NEK2 NINL NONO PSMA1 RNF8 SIN3A SIN3B SPATA2 TEX11 TPM1 TPM3 TPR TRIM29 TSC22D3 TSHZ3 TUBGCP4 UBC UBTF USP15 ZSCAN32	16 interactors: APBB1 CCDC155 CEP63 CEP70 CTBP1 CTBP2 KRT40 MAD1L1 MTUS2 SPAG5 TAX1BP1 TFIP11 TRAF2 TRIM23 TRIM27 TRIM54
Entrez ID		8379	57616
HPRD ID		04065	18351
Ensembl ID		ENSG00000002822	ENSG00000121297
Uniprot IDs		B3KR41 Q9Y6D9	Q63HK5
PDB IDs		1GO4 4DZO	2DMI
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Gene Expression Mitotic Cell Cycle Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Mitotic Cell Cycle Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Chromosome Organization Cell Cycle Process Negative Regulation Of Biosynthetic Process Cell Cycle Organelle Organization Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Cell Death Histone Deacetylation Protein Deacetylation Negative Regulation Of Ubiquitin-protein Transferase Activity Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Gene Expression, Epigenetic Mitotic Nuclear Division Regulation Of Ubiquitin-protein Transferase Activity RNA Biosynthetic Process Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Protein Ubiquitination Positive Regulation Of Cell Cycle Process Histone Modification Regulation Of Protein Catabolic Process Regulation Of Cell Cycle Phase Transition Chromatin Modification Regulation Of Apoptotic Process Regulation Of Mitotic Cell Cycle Transcription From RNA Polymerase II Promoter G2/M Transition Of Mitotic Cell Cycle Cell Division Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Proteasomal Protein Catabolic Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Cell Death Regulation Of Cell Cycle Regulation Of Proteolysis Negative Regulation Of Cell Cycle Positive Regulation Of Spindle Checkpoint Transcription, DNA-templated Positive Regulation Of Cell Cycle Chromatin Organization	Cell Cycle Process White Fat Cell Differentiation Cell Cycle Viral Genome Replication Regulation Of Organelle Organization Organelle Organization Protein K63-linked Ubiquitination Protein Trimerization Regulation Of Cellular Component Organization Mitotic Cell Cycle Process Regulation Of Metaphase Plate Congression Chromosome Localization To Nuclear Envelope Involved In Synapsis Spliceosomal Complex Disassembly Negative Regulation Of Transcription From RNA Polymerase II Promoter By Histone Modification Negative Regulation Of Thymidylate Synthase Biosynthetic Process Mitotic Cell Cycle Mitotic Nuclear Division Regulation Of Chromosome Segregation Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Chromosome Organization Negative Regulation Of Interleukin-2 Secretion Negative Regulation Of Protein Metabolic Process Cell Division G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Binding Chromosome Organization Regulation Of Cellular Localization Fat Cell Differentiation Spindle Organization Regulation Of Cytoskeleton Organization Positive Regulation Of Retinoic Acid Receptor Signaling Pathway Regulation Of Microtubule Cytoskeleton Organization Double-strand Break Repair Negative Regulation Of Calcium Ion Import Positive Regulation Of Chromatin Binding Regulation Of Cytokine Production Viral Process Negative Regulation Of Glial Cell Apoptotic Process Protein Ubiquitination Regulation Of Microtubule-based Process Protein Polyubiquitination Protein Modification By Small Protein Conjugation Interferon-gamma Secretion Viral Life Cycle Negative Regulation Of Histone H4 Acetylation Regulation Of Adaptive Immune Response Regulation Of Chromosome Organization Positive Regulation Of Protein Homodimerization Activity Regulation Of Protein Metabolic Process Regulation Of Transcription, DNA-templated
Tagcloud ?		adverse altered aneuploidy arrest biomarker carcinogenesis characteristic checkpoint checkpoints chromosomal clinicopathological contraindication correlation defects instability mammary microarray mitotic nuclei ones os pacilitaxel predict shorter subtypes taxol undergone whose worse	chip deep dysregulated dysregulation h3k27me3 homeobox hox hoxb7 hoxc10 hoxc13 hoxd8 irx1 irx4 keratinocytes mark neoplastic okf6 oncomine polycomb prc prc2 repressive rnaseq scc six2 suz12 tert1r transcripts tumorigenic
Tagcloud (Difference) ?		adverse altered aneuploidy arrest biomarker carcinogenesis characteristic checkpoint checkpoints chromosomal clinicopathological contraindication correlation defects instability mammary microarray mitotic nuclei ones os pacilitaxel predict shorter subtypes taxol undergone whose worse	chip deep dysregulated dysregulation h3k27me3 homeobox hox hoxb7 hoxc10 hoxc13 hoxd8 irx1 irx4 keratinocytes mark neoplastic okf6 oncomine polycomb prc prc2 repressive rnaseq scc six2 suz12 tert1r transcripts tumorigenic
Tagcloud (Intersection) ?