MAD1L1 and NONO

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		MAD1L1	NONO
Gene Name		MAD1 mitotic arrest deficient-like 1 (yeast)	non-POU domain containing, octamer-binding
Image
Gene Ontology Annotations	Cellular Component	Kinetochore Condensed Chromosome Kinetochore Nucleus Nuclear Pore Cytoplasm Centrosome Spindle Cytosol Actin Cytoskeleton Mitotic Spindle	Nucleus Nucleoplasm Nucleolus Membrane Nuclear Matrix Nuclear Speck Paraspeckles
	Molecular Function	Protein Binding	Nucleotide Binding Core Promoter Binding Protein Binding Identical Protein Binding Poly(A) RNA Binding
	Biological Process	Mitotic Cell Cycle Mitotic Nuclear Division Mitotic Cell Cycle Checkpoint Mitotic Spindle Assembly Checkpoint Cell Division Regulation Of Metaphase Plate Congression	DNA Repair DNA Recombination Transcription, DNA-templated MRNA Processing Circadian Rhythm RNA Splicing Regulation Of Circadian Rhythm Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway
Pathways		Mitotic Spindle Checkpoint Amplification of signal from the kinetochores Mitotic Prometaphase Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Cell Cycle Checkpoints Mitotic Anaphase Mitotic Metaphase and Anaphase Cell Cycle, Mitotic M Phase
Drugs
Diseases
GWAS		Bipolar disorder ( 21926972) Longevity ( 20834067) Schizophrenia ( 22688191) Testicular germ cell tumor ( 23666239)
Protein-Protein Interactions		38 interactors: ALOX5 AMOTL2 BAG5 CCDC94 CCHCR1 COIL CWF19L2 FAM131C HAUS1 HDAC1 HDAC2 LGALSL MAD2L1 MAX MFAP1 MLX NDC80 NEBL NEK2 NINL NONO PSMA1 RNF8 SIN3A SIN3B SPATA2 TEX11 TPM1 TPM3 TPR TRIM29 TSC22D3 TSHZ3 TUBGCP4 UBC UBTF USP15 ZSCAN32	35 interactors: APBB1 AR C11orf68 CA2 DDX6 ERG EWSR1 FXR2 HIST3H3 IL7R IRAK3 LMO4 MAD1L1 NUPR1 ORC5 PIN1 PLEKHF2 POLR2A PPP1CA PPP1CB PPP1CC PRKAA2 PRPF40A PSPC1 PTBP1 SFPQ SMARCB1 SMARCC1 SMARCD1 SPI1 SYNPO TCERG1 WBP4 YLPM1 ZNRD1
Entrez ID		8379	4841
HPRD ID		04065	02098
Ensembl ID		ENSG00000002822	ENSG00000147140
Uniprot IDs		B3KR41 Q9Y6D9	Q15233
PDB IDs		1GO4 4DZO	3SDE
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Gene Expression Mitotic Cell Cycle Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Mitotic Cell Cycle Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Chromosome Organization Cell Cycle Process Negative Regulation Of Biosynthetic Process Cell Cycle Organelle Organization Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Cell Death Histone Deacetylation Protein Deacetylation Negative Regulation Of Ubiquitin-protein Transferase Activity Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Gene Expression, Epigenetic Mitotic Nuclear Division Regulation Of Ubiquitin-protein Transferase Activity RNA Biosynthetic Process Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Protein Ubiquitination Positive Regulation Of Cell Cycle Process Histone Modification Regulation Of Protein Catabolic Process Regulation Of Cell Cycle Phase Transition Chromatin Modification Regulation Of Apoptotic Process Regulation Of Mitotic Cell Cycle Transcription From RNA Polymerase II Promoter G2/M Transition Of Mitotic Cell Cycle Cell Division Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Proteasomal Protein Catabolic Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Cell Death Regulation Of Cell Cycle Regulation Of Proteolysis Negative Regulation Of Cell Cycle Positive Regulation Of Spindle Checkpoint Transcription, DNA-templated Positive Regulation Of Cell Cycle Chromatin Organization	Regulation Of Gene Expression RNA Metabolic Process Gene Expression Regulation Of Circadian Rhythm Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Nitrogen Compound Metabolic Process Nucleosome Disassembly Cellular Macromolecule Biosynthetic Process Cellular Metabolic Process Macromolecule Biosynthetic Process Entrainment Of Circadian Clock By Photoperiod Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Triglyceride Catabolic Process Rhythmic Process Photoperiodism Entrainment Of Circadian Clock Regulation Of Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Acylglycerol Catabolic Process Cell Cycle Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Chromatin Modification Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Glycogen Catabolic Process Energy Reserve Metabolic Process Chromatin Organization Chromosome Organization Biosynthetic Process Regulation Of Cellular Process Glycogen Metabolic Process MRNA Metabolic Process RNA Splicing Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Generation Of Precursor Metabolites And Energy Transcription From RNA Polymerase II Promoter Circadian Regulation Of Gene Expression Positive Regulation Of Gene Expression Regulation Of Cellular Component Organization Polysaccharide Metabolic Process
Tagcloud ?		adverse altered aneuploidy arrest biomarker carcinogenesis characteristic checkpoint checkpoints chromosomal clinicopathological contraindication correlation defects instability mammary microarray mitotic nuclei ones os pacilitaxel predict shorter subtypes taxol undergone whose worse	acth adrenal adrenocortical adrenocorticotropin belongs biosynthesis camp confers cortisol cyp17a1 dbhs exoribonuclease export facilitating glucocorticoid h295r isoforms p54nrb pde pde11a pde2a pde3a pde3b pde4a pde4d phosphodiesterase select splicing xrn2
Tagcloud (Difference) ?		adverse altered aneuploidy arrest biomarker carcinogenesis characteristic checkpoint checkpoints chromosomal clinicopathological contraindication correlation defects instability mammary microarray mitotic nuclei ones os pacilitaxel predict shorter subtypes taxol undergone whose worse	acth adrenal adrenocortical adrenocorticotropin belongs biosynthesis camp confers cortisol cyp17a1 dbhs exoribonuclease export facilitating glucocorticoid h295r isoforms p54nrb pde pde11a pde2a pde3a pde3b pde4a pde4d phosphodiesterase select splicing xrn2
Tagcloud (Intersection) ?