MAPK15 and CSK

Number of citations of the paper that reports this interaction (PMID 11875070)
22

Data Source:
HPRD (in vivo)

		MAPK15	CSK
Gene Name		mitogen-activated protein kinase 15	c-src tyrosine kinase
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Intracellular Nucleus	Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Membrane Raft Extracellular Vesicular Exosome
	Molecular Function	MAP Kinase Activity ATP Binding SH3 Domain Binding	Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Receptor Binding Protein Binding ATP Binding Protein C-terminus Binding Protein Phosphatase Binding Identical Protein Binding Proline-rich Region Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter MAPK Cascade Positive Regulation Of Protein Phosphorylation Negative Regulation Of DNA Replication Positive Regulation Of Protein Ubiquitination Response To Estradiol Positive Regulation Of Protein Catabolic Process Protein Autophosphorylation	Regulation Of Cytokine Production Morphogenesis Of An Epithelium Protein Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Central Nervous System Development Brain Development Blood Coagulation Negative Regulation Of Cell Proliferation Negative Regulation Of Low-density Lipoprotein Particle Clearance Cell Migration Cell Differentiation Platelet Activation T Cell Costimulation Negative Regulation Of Interleukin-6 Production Negative Regulation Of Kinase Activity Adherens Junction Organization Peptidyl-tyrosine Autophosphorylation Regulation Of Cell Proliferation Negative Regulation Of Golgi To Plasma Membrane Protein Transport Positive Regulation Of MAP Kinase Activity Innate Immune Response Negative Regulation Of Bone Resorption Oligodendrocyte Differentiation Negative Regulation Of Phagocytosis T Cell Receptor Signaling Pathway Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Negative Regulation Of ERK1 And ERK2 Cascade Cellular Response To Peptide Hormone Stimulus
Pathways			Costimulation by the CD28 family GAB1 signalosome Integrin alphaIIb beta3 signaling Signaling by Ligand-Responsive EGFR Variants in Cancer Signaling by EGFRvIII in Cancer Platelet Aggregation (Plug Formation) Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by EGFR TCR signaling Signaling by EGFR in Cancer PD-1 signaling Platelet activation, signaling and aggregation Phosphorylation of CD3 and TCR zeta chains Adaptive Immune System
Drugs			Staurosporine
Diseases
GWAS		Obesity-related traits ( 23251661)	Blood pressure ( 21909110) Caffeine consumption ( 21490707) Diastolic blood pressure ( 19430479 19430483) Systemic lupus erythematosus and Systemic sclerosis ( 23740937)
Protein-Protein Interactions		8 interactors: CLIC3 CSK GABARAP GABARAPL1 MBP NR3C1 SRC TGFB1I1	46 interactors: ADRB2 ARRB1 CAV1 CD247 CD3E CD44 CDH5 CREBBP DAB2 DOK1 DOK3 FGR FHL2 FYN G3BP1 GJA1 GSN HCK HNRNPK ID3 IGF1R INSR KHDRBS1 LAIR1 LCK LYN MAPK15 PAG1 PECAM1 PLD2 PRKACA PTK2 PTPN12 PTPN18 PTPN22 PXN RASA1 RGS16 SDC3 SHC1 SIT1 SRC TGFB1I1 TLR3 ZAP70 ZNF212
Entrez ID		225689	1445
HPRD ID		16867	00496
Ensembl ID		ENSG00000181085	ENSG00000103653
Uniprot IDs		Q8TD08	A8K3B6 B2R6Q4 P41240
PDB IDs			1BYG 1CSK 3D7T 3D7U 3EAC 3EAZ
Enriched GO Terms of Interacting Partners?		Intracellular Steroid Hormone Receptor Signaling Pathway Cell Communication Morphogenesis Of An Epithelium Nucleophagy Intracellular Receptor Signaling Pathway Tissue Morphogenesis Mitochondrion Degradation Regulation Of Bone Resorption Organelle Disassembly Peptidyl-tyrosine Autophosphorylation Regulation Of Bone Remodeling Autophagic Vacuole Assembly Membrane Organization Response To Progesterone Response To Hormone Macroautophagy Mammary Gland Duct Morphogenesis Response To Stress Regulation Of Tissue Remodeling Response To Stimulus Response To Fatty Acid Epithelium Development Negative Regulation Of Signal Transduction Signaling T Cell Costimulation Response To Nutrient Levels Mammary Gland Morphogenesis Glucocorticoid Mediated Signaling Pathway Adherens Junction Organization Negative Regulation Of Signaling Response To Extracellular Stimulus Response To Steroid Hormone Mammary Gland Epithelium Development Regulation Of Glucose Metabolic Process Vacuole Organization Regulation Of Cytokine Production Cellular Response To Progesterone Stimulus Cellular Response To Hormone Stimulus Cellular Response To Stimulus Membrane Fusion Cellular Response To Starvation Defense Response To Nematode Negative Regulation Of Glucocorticoid Mediated Signaling Pathway Positive Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of Carbohydrate Metabolic Process Gland Morphogenesis Autophagy Epidermal Growth Factor Receptor Signaling Pathway Response To Corticosteroid ERBB Signaling Pathway	Signal Transduction Peptidyl-tyrosine Autophosphorylation Signaling Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Cell Communication Positive Regulation Of Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Signal Transduction Cellular Response To Stimulus Regulation Of Signaling Cell Surface Receptor Signaling Pathway Positive Regulation Of Phosphorylation Regulation Of Cell Adhesion Protein Autophosphorylation Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Regulation Of Cell-cell Adhesion Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Protein Phosphorylation Cellular Response To Peptide Hormone Stimulus Response To Stimulus Positive Regulation Of Protein Metabolic Process Cellular Response To Peptide Regulation Of Protein Phosphorylation Peptidyl-tyrosine Phosphorylation Response To Peptide Hormone Immune System Process Regulation Of Intracellular Signal Transduction Response To Peptide Positive Regulation Of Protein Modification Process Positive Regulation Of Immune System Process Intracellular Signal Transduction Leukocyte Migration Positive Regulation Of Cellular Protein Metabolic Process Response To Hormone Regulation Of Immune System Process Regulation Of Phosphorylation Regulation Of Protein Metabolic Process Response To Wounding Cellular Response To Organonitrogen Compound Regulation Of Cell Activation Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Wound Healing Negative Regulation Of Signal Transduction Regulation Of T Cell Activation Regulation Of Phosphorus Metabolic Process Positive Regulation Of Immune Response Innate Immune Response
Tagcloud ?		atypical autonomous autonomously biogenesis consequently coordinates delay dilp dilps drosophila effector epistatically erk7 erk8 humoral impede ipcs larval limiting neurosecretory nutrient nutrition operates ribosome secreting secretion starvation surveillance uncover	associate clone cloning cytokine element elk far fos gh ghr grb10 grb4 hepatoma huh library member p85 phosphatidylinositol radiolabeled reporter screen sh2 shb shc spi2 stat5 superfamily transducers transfections
Tagcloud (Difference) ?		atypical autonomous autonomously biogenesis consequently coordinates delay dilp dilps drosophila effector epistatically erk7 erk8 humoral impede ipcs larval limiting neurosecretory nutrient nutrition operates ribosome secreting secretion starvation surveillance uncover	associate clone cloning cytokine element elk far fos gh ghr grb10 grb4 hepatoma huh library member p85 phosphatidylinositol radiolabeled reporter screen sh2 shb shc spi2 stat5 superfamily transducers transfections
Tagcloud (Intersection) ?